DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment st and ABCG4

DIOPT Version :9

Sequence 1:	NP_524108.1	Gene:	st / 39836	FlyBaseID:	FBgn0003515	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	NP_194305.1	Gene:	ABCG4 / 828680	AraportID:	AT4G25750	Length:	577	Species:	Arabidopsis thaliana

Alignment Length:	603	Identity:	172/603 - (28%)
Similarity:	280/603 - (46%)	Gaps:	91/603 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 IINNSTGAIQPGTLMALMGSSGSGKTTLMSTLAFRQPAGTVVQGDILINGRRIGPFMHR-ISGYV 153
            |:.|.|....|..::|::|.||:||:||:..||.|.   :...|.||:|...|.|..:| ||.||
plant    30 ILRNITLTSHPSQILAIIGPSGAGKSTLLDILAART---SPTSGSILLNSVLINPSSYRKISSYV 91

  Fly   154 YQDDLFLGSLTVLEHLNFMAHLRLDRRVSKEERRLIIKELLERTGLLSAAQTRIGSGDDKKVLSG 218
            .|.|.|...|||.|...|.|.|.|.:.:||...  ::..||:...|...|.||:|.|     |||
plant    92 PQHDTFFPLLTVSETFTFSASLLLPKNLSKVSS--VVASLLKELNLTHLAHTRLGQG-----LSG 149

  Fly   219 GERKRLAFAVELLNNPVILFCDEPTTGLDSYSAQQLVATLYELA-QKGTTILCTIHQPSSQLFDN 282
            |||:|::..:.||::|.:|..||||:||||.||..:|..|..:| .:...::.:|||||.::...
plant   150 GERRRVSIGLSLLHDPEVLLLDEPTSGLDSKSAFDVVQILKSIATSRERIVILSIHQPSFKILSL 214

  Fly   283 FNNVMLLADGRVAFTGSPQHALSFFANHGYYCPEAYNPADFLIGVLAT--DPGYEQASQRSAQHL 345
            .:.|:||:.|.:.:.|......:|..:.|:..|...|..::.:.:|..  || ||.|:.....|
plant   215 IDRVLLLSKGTIVYHGRLDLLEAFLLSKGFTVPSQLNSLEYAMEILQNIRDP-YENANIALPDH- 277

  Fly   346 CDQFAVSSAAKQRDMLVN------LEIHMAQSGNFPFDTEVESFRGVAWYKRFHVVWLRASLTLL 404
            |.:   |....|:..:|.      .||.:..|                   ||..:..|....||
plant   278 CPE---SKKQNQKQSIVRYKSSRITEISLLSS-------------------RFWKIIYRTRQLLL 320

  Fly   405 RDPTIQWLRFIQKIAMAFIIGACF--AGTTEPSQLGVQAVQG----ALFIMISENTYHPMYSVLN 463
            .:       .::.:.:..::|..:  .||   .:.|::...|    .|..::|..|     ..|.
plant   321 TN-------ILESLVVGLVLGTIYLNIGT---GKEGIRKRFGLFAFTLTFLLSSTT-----QTLP 370

  Fly   464 LFPQGFPLFMRETRSGLYSTGQYYAANILALLPGMIIEPLIFVIICYWLTGLRSTFYAFGVTAMC 528
            :|....|:.:|||.||||....:..||.|..||.:::..:|:.:..|:|.||..::.|.....:.
plant   371 IFIDERPILLRETSSGLYRLSSHILANTLVFLPYLLLIAIIYSVSLYFLVGLCFSWQALAYFVLV 435

  Fly   529 VVLVMNVATACGCFFSTAFNSVPLAMAYLVPLDYI------------FMITSGIFIQVNSLPVAF 581
            :.:::.:|           ||..|.::.|.| :||            |.:.||.||...|||..:
plant   436 IWIIVLMA-----------NSFVLFLSSLAP-NYIAGTSSVTILLAAFFLFSGYFISKESLPKYW 488

  Fly   582 WWTQFLSWMLYANEAMTAAQWSGVQN--ITCFQESADLPCFHTGQDVLDKYSFNESNVYRNLLAM 644
            .:..|.|...||.:|:...::|.:.|  :..|:|::...|..||.|||||...:|...:.|:..:
plant   489 LFMYFFSMYKYALDALLINEYSCLHNKCLVWFEEASVNSCLVTGGDVLDKNGLHERQRWFNVYML 553

  Fly   645 VGLYFGFHLLGYYCLWRR 662
            :|.:..:.:|.:..|.:|
plant   554 LGFFVLYRVLCFLVLLKR 571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
st	NP_524108.1	ABCG_EPDR	66..298	CDD:213180	80/209 (38%)
		3a01204	67..665	CDD:273361	172/603 (29%)
		ABC2_membrane	395..600	CDD:279410	53/222 (24%)
ABCG4	NP_194305.1	3a01204	30..572	CDD:273361	172/603 (29%)
		P-loop_NTPase	30..230	CDD:304359	80/209 (38%)
		ABC2_membrane	304..507	CDD:279410	56/248 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48041
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.880