DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment st and ABCG2

DIOPT Version :9

Sequence 1:	NP_524108.1	Gene:	st / 39836	FlyBaseID:	FBgn0003515	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	NP_181272.1	Gene:	ABCG2 / 818312	AraportID:	AT2G37360	Length:	755	Species:	Arabidopsis thaliana

Alignment Length:	741	Identity:	194/741 - (26%)
Similarity:	320/741 - (43%)	Gaps:	116/741 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SDSKRIDVEAPERV---------EQHELQVMPVGSTIEVPSLDSTPKLSKRNSSERSLPL----- 54
            ||:.|:.|...|.:         |....:.:.:.|.|...:.......|...||..|.|.
plant    37 SDTTRVSVTFAEHLMNVEDARNDESASSRALGIASPINSAASSFNSWASAPASSISSSPFVLSFT 101

  Fly    55 -RSYS-----KWSPTEQGATLVWRDLCVYTNVGGSGQRMKRIINNSTGAIQPGTLMALMGSSGSG 113
             .:||     |::|.          .|...:...|....|.::|..:|..:.|.:||::|:||||
plant   102 DLTYSVKIQKKFNPL----------ACCRRSGNDSSVNTKILLNGISGEAREGEMMAVLGASGSG 156

  Fly   114 KTTLMSTLAFRQPAGTVVQGDILINGRRIGPFMHR-ISGYVYQDDLFLGSLTVLEHLNFMAHLRL 177
            |:||:..||.| .|...::|.|.:||..:...|.: ||.||.||||....|||.|.|.|.|..||
plant   157 KSTLIDALANR-IAKDSLRGSITLNGEVLESSMQKVISAYVMQDDLLFPMLTVEETLMFSAEFRL 220

  Fly   178 DRRVSKEERRLIIKELLERTGLLSAAQTRIGSGDDKKVLSGGERKRLAFAVELLNNPVILFCDEP 242
            .|.:||::::..::.|:::.||.|||:|.||. :..:.:|||||:|::...:::::|:|||.|||
plant   221 PRSLSKKKKKARVQALIDQLGLRSAAKTVIGD-EGHRGVSGGERRRVSIGNDIIHDPIILFLDEP 284

  Fly   243 TTGLDSYSAQQLVATLYELAQKGTTILCTIHQPSSQLFDNFNNVMLLADGRVAFTGSPQHALSFF 307
            |:||||.||..::..|..:||.|:.::.:|||||.::....:.::.|:.|...::|||.|...||
plant   285 TSGLDSTSAYMVIKVLQRIAQSGSIVIMSIHQPSYRIMGLLDQLIFLSKGNTVYSGSPTHLPQFF 349

  Fly   308 ANHGYYCPEAYNPADFLIGVL-----ATD-----------------PGYEQASQRSAQHLCDQFA 350
            :...:..||..|..:|.:.::     :|:                 |.|...::|:..
plant   350 SEFKHPIPENENKTEFALDLIRELEYSTEGTKPLVEFHKQWRAKQAPSYNNNNKRNTN------- 407

  Fly   351 VSS------AAKQRDMLVNLEIHMAQSGNFPFDTEVESFRGVAWYKRFHVVWLRASLTLLRDPTI 409
            |||      |:..|..||:...:...|...|   ..::|....|.:.. |:..||.|...|.|.:
plant   408 VSSLKEAITASISRGKLVSGATNNNSSNLTP---SFQTFANPFWIEMI-VIGKRAILNSRRQPEL 468

  Fly   410 QWLRFIQKIAMAFIIGACFAGTTEPSQLGVQAVQGALFIMISENTYHPMYSVLNLFPQGFPLFMR 474
            ..:|....:....|:...|. ..:.|..|.|...| .|......|::.....:.:|.|...:|||
plant   469 LGMRLGAVMVTGIILATMFT-NLDNSPKGAQERLG-FFAFAMSTTFYTCAEAIPVFLQERYIFMR 531

  Fly   475 ETRSGLYSTGQYYAANILALLPGMIIEPLIFVIICYWLTGL---RSTFYAFGVTAMCVVLVMNVA 536
            ||....|....|..:..:..:|.:|:....|....:|..||   .:.|:.|..|   ::......
plant   532 ETAYNAYRRSSYVLSQSIISIPALIVLSASFAATTFWAVGLDGGANGFFFFYFT---ILASFWAG 593

  Fly   537 TACGCFFSTAFNSVPLAMAYLVPLDYIFMITSGIFIQVNSLPVAFWWTQFLSWMLYANEAMTAAQ 601
            ::...|.|....:|.|....:|.:...|::.||.||..:.:||.:.|..::|.:.|..|.:...:
plant   594 SSFVTFLSGVIPNVMLGFTVVVAILAYFLLFSGFFISRDRIPVYWLWFHYISLVKYPYEGVLQNE 658

  Fly   602 WSGVQNIT-CFQESADL--------------------------------PCFHTGQDVLDKYSFN 633
            :   ||.| ||.....|                                .|..||.|:|.:....
plant   659 F---QNPTRCFARGVQLFDNSPLGEFPNDVKVNLLKSMSGVLGTNVTAETCVTTGIDILKQQGIT 720

  Fly   634 ESNVYRNLLAMVGLYFGFHLLGYYCL 659
            :.:.:..|...|...|.|.:|.|:.|
plant   721 DISKWNCLWITVAWGFFFRVLFYFTL 746

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
st	NP_524108.1	ABCG_EPDR	66..298	CDD:213180	85/232 (37%)
		3a01204	67..665	CDD:273361	177/658 (27%)
		ABC2_membrane	395..600	CDD:279410	48/207 (23%)
ABCG2	NP_181272.1	3a01204	95..754	CDD:273361	182/683 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48041
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.880