DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment st and ABCG5

DIOPT Version :9

Sequence 1:	NP_524108.1	Gene:	st / 39836	FlyBaseID:	FBgn0003515	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	NP_178984.1	Gene:	ABCG5 / 815846	AraportID:	AT2G13610	Length:	649	Species:	Arabidopsis thaliana

Alignment Length:	610	Identity:	170/610 - (27%)
Similarity:	283/610 - (46%)	Gaps:	62/610 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 SGQRMKRIINNSTGAIQPGTLMALMGSSGSGKTTLMSTLAFRQPAGTVVQGDILINGRRIG-PFM 146
            :|.::|.::...|...:|..::|::|.||:||::|:..||.|....|   |.:.:|.|.:. ...
plant    55 TGNKVKHVLKGVTCRAKPWEILAIVGPSGAGKSSLLEILAARLIPQT---GSVYVNKRPVDRANF 116

  Fly   147 HRISGYVYQDDLFLGSLTVLEHLNFMAHLRLDRRVSKEERRLIIKELLERTGLLSAAQTRIGSGD 211
            .:|||||.|.|.....|||.|.|.|.|.|||  ::..:|.|..:|.|:...||.:.|..|:|. |
plant   117 KKISGYVTQKDTLFPLLTVEETLLFSAKLRL--KLPADELRSRVKSLVHELGLEAVATARVGD-D 178

  Fly   212 DKKVLSGGERKRLAFAVELLNNPVILFCDEPTTGLDSYSAQQLVATLYELAQ-KGTTILCTIHQP 275
            ..:.:|||||:|::..||::::|.:|..||||:||||.||..::..|..:|: :|.||:.|||||
plant   179 SVRGISGGERRRVSIGVEVIHDPKVLILDEPTSGLDSTSALLIIDMLKHMAETRGRTIILTIHQP 243

  Fly   276 SSQLFDNFNNVMLLADGRVAFTGSPQHALSFFANHGYYCPEAYNPADFLIGVL--ATDPGYEQAS 338
            ..::...||:|:|||:|.....||......:..::|.:.|...|..:|.|..:  .|.....|.|
plant   244 GFRIVKQFNSVLLLANGSTLKQGSVDQLGVYLRSNGLHPPLHENIVEFAIESIESITKQQRLQES 308

  Fly   339 QRSAQHLCDQFAV-----------SSAAKQRDMLVNLEIHMAQSGNFPFDTEVESFRGVAWYKRF 392
            :|:|..|..|..:           |.:.|.....:..:..:|..|.....||.......:..:..
plant   309 RRAAHVLTPQTTLQEKRSEDSQGESKSGKFTLQQLFQQTRVADVGTMNIATEFTRDFANSRLEET 373

  Fly   393 HVVWLRASLTLLRDPTIQWLRFIQKIAMAFIIGACFAGTTEPSQLGVQAVQGA-----LFIMISE 452
            .::..|.|..:.|...:...|.:|.:....::|..|....:.       ::||     ||..|..
plant   374 MILTHRFSKNIFRTKELFACRTVQMLGSGIVLGLIFHNLKDD-------LKGARERVGLFAFILT 431

  Fly   453 NTYHPMYSVLNLFPQGFPLFMRETRSGLYSTGQYYAANILALLPGMIIEPLIFVIICYWLTGLRS 517
            .........|.:|.|...:.|:||.||.|....|..||.|..||.::|..::|....|||.||..
plant   432 FLLTSTIEALPIFLQEREILMKETSSGSYRVSSYAVANGLVYLPFLLILAILFSTPVYWLVGLNP 496

  Fly   518 TFYAFGVTAMCVVLVMNVATACGCFFSTAFNSVPLAMAYLVPLDYI------------FMITSGI 570
            :|.||...::.:.|::..|           |||.:..:.||| ::|            |.:.||.
plant   497 SFMAFLHFSLLIWLILYTA-----------NSVVVCFSALVP-NFIVGNSVISGVMGSFFLFSGY 549

  Fly   571 FIQVNSLPVAFW-WTQFLSWMLYANEAMTAAQWSGVQNITCFQESADLPCFHTGQDVLDKYSFNE 634
            ||..:.:| .:| :..::|...|..|.....::|  ::..|.:.... .|..|.:|:|.:..:.|
plant   550 FISNHEIP-GYWIFMHYISLFKYPFEGFLINEFS--KSNKCLEYGFG-KCLVTEEDLLKEERYGE 610

  Fly   635 SNVYRNLLAMVGLYFGFHLLGYYCL 659
            .:.:||::.|:.....:..:.|..|
plant   611 ESRWRNVVIMLCFVLLYRFISYVIL 635

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
st	NP_524108.1	ABCG_EPDR	66..298	CDD:213180	82/216 (38%)
		3a01204	67..665	CDD:273361	170/610 (28%)
		ABC2_membrane	395..600	CDD:279410	56/222 (25%)
ABCG5	NP_178984.1	3a01204	37..638	CDD:273361	170/610 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48041
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920