DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment st and abcg2a

DIOPT Version :9

Sequence 1:	NP_524108.1	Gene:	st / 39836	FlyBaseID:	FBgn0003515	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	XP_021325521.1	Gene:	abcg2a / 735312	ZFINID:	ZDB-GENE-050517-35	Length:	644	Species:	Danio rerio

Alignment Length:	630	Identity:	191/630 - (30%)
Similarity:	317/630 - (50%)	Gaps:	54/630 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 SPTEQGATLVWRD----LCVYTNVGGSGQRMKRIINNSTGAIQPGTLMALMGSSGSGKTTLMSTL 121
            ||:.:|||:.:.:    |.:.:....|....|.|:....|.::|| |.|::|::||||::.:..|
Zfish    25 SPSRRGATVSFHNINYSLKMKSGFCKSKSTKKNILIGLNGIMKPG-LNAILGATGSGKSSFLDVL 88

  Fly   122 AFRQ-PAGTVVQGDILINGRRIGPFMHRISGYVYQDDLFLGSLTVLEHLNFMAHLRLDRRVSKEE 185
            |.|: |||  :.|::||:|....|....:||||.|||:.:|:|||.|:|.|.|.|||.:.:.:.|
Zfish    89 AARKDPAG--LSGEVLIDGAPQPPNFKCLSGYVVQDDVVMGTLTVRENLRFSAALRLPKSIKQRE 151

  Fly   186 RRLIIKELLERTGLLSAAQTRIGSGDDKKVLSGGERKRLAFAVELLNNPVILFCDEPTTGLDSYS 250
            :...::.|::..||...|.:|:|:...:.| |||||||....:||:.:|.:||.||||||||:.:
Zfish   152 KDEKVERLIQELGLSKVADSRVGTQLIRGV-SGGERKRTNIGMELIIDPPVLFLDEPTTGLDAST 215

  Fly   251 AQQLVATLYELAQKGTTILCTIHQPSSQLFDNFNNVMLLADGRVAFTGSPQHALSFFANHGYYCP 315
            |..::..|.::...|.||:.:||||...::..|:::.||..|::.:.|..|.|||:|:..||.|.
Zfish   216 ANSVLMLLKKMGNNGRTIILSIHQPRYSIYRLFDSLTLLVGGKLVYHGPAQDALSYFSQIGYTCE 280

  Fly   316 EAYNPADFLIGVLATDPG-------YEQASQRSAQHLCDQFAVSSAAK----------QRDML-- 361
            ...|||||.:.|:..|..       ||:        :.||..:||:.|          ||..:
Zfish   281 PHNNPADFFLDVINGDSSAVTLNKLYEE--------VVDQDQLSSSLKGIEDRLVEEYQRSSIFQ 337

  Fly   362 -VNLEIHMAQSGNFPFDTEVES---FRGVAWYKRFHVVWLRASLTLLRDPTIQWLRFIQKIAMAF 422
             .:.::.....|. .:.|..:|   ....::..:||.|..|....|:.:|.....:....|.:|.
Zfish   338 QTHADLQRIVQGQ-DYSTRPKSRTITYSTSFCHQFHWVLKRTFRNLMLNPQTSVAQIGVMIFLAL 401

  Fly   423 IIGACFAGTTEPSQLGVQAVQGALFIMISENTYHPMYSVLNLFPQGFPLFMRETRSGLYSTGQYY 487
            ::||.|.|..|.|. |:|...|||| .|:.|......|...||.....||:.|..||.|....|:
Zfish   402 VVGAIFFGVAENSS-GIQNRMGALF-FITTNQCFSSVSAAELFIAERKLFVHEYISGYYRVSVYF 464

  Fly   488 AANILA-LLPGMIIEPLIFVIICYWLTGLRSTFYAFGVTAMCVVLVMNVATACGCFFSTAFNSVP 551
            .:.||: :|....|..:||..:.|::.||:....||.:....:::|...|||.....|.....|.
Zfish   465 LSKILSDILTLRTIPAVIFSCVAYFMIGLKPAAEAFFIFLFSIIMVSYTATAMTLAISADQTVVA 529

  Fly   552 LAMAYLVPLDYIF-MITSGIFIQVNSLPVAFW--WTQFLSWMLYANEAMTAAQWSGVQNITCFQE 613
            :|..::. :.::| ||.||:.:.:.|  ||.|  |.::.|...|...|:...:::|:  ..|...
Zfish   530 IANIFMT-ISFVFMMIFSGLLVNLPS--VATWLNWLKYFSIPRYGLSALQINEFTGL--FFCDNR 589

  Fly   614 SADLPCFHTGQDVLDKYSFNES--NVYRNLLAMVGLYFGFHLLGY 656
            :.......:|::.|.:...:.|  .:::|.||:..:.|.|..:.|
Zfish   590 NNSGSVCSSGEEFLQEQGIDYSAWGLWQNHLALGIMTFIFLCIAY 634

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
st	NP_524108.1	ABCG_EPDR	66..298	CDD:213180	87/236 (37%)
		3a01204	67..665	CDD:273361	188/624 (30%)
		ABC2_membrane	395..600	CDD:279410	61/208 (29%)
abcg2a	XP_021325521.1	PRK10535	43..638	CDD:333000	185/612 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574345
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	1	1.000	-	-		mtm6474
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.850