Protein Alignment st and ABCG5

DIOPT Version :9

• Sequence 1: NP_524108.1
• Gene: st / 39836
• FlyBaseID: FBgn0003515
• Length: 666
• Species: Drosophila melanogaster
• Sequence 2: NP_071881.1
• Gene: ABCG5 / 64240
• HGNCID: 13886
• Length: 651
• Species: Homo sapiens
• Alignment Length: 602
• Identity: 169/602 - (28%)
• Similarity: 285/602 - (47%)
• Gaps: 70/602 - (11%)

  Fly    85 QRMKRIINNSTGAIQPGTLMALMGSSGSGKTTLMSTLAFR-QPAGTVVQGDILINGR--RIGPFM 146
            |..::|:.:.:..::.|.:|.::||||||||||:..::.| ..|||.: |::.:|||  |...|.
Human    63 QWTRQILKDVSLYVESGQIMCILGSSGSGKTTLLDAMSGRLGRAGTFL-GEVYVNGRALRREQFQ 126

  Fly   147 HRISGYVYQDDLFLGSLTVLEHLNFMAHLRLDRRVSKEERRLIIKELLERTGLLSAAQTRIGS-- 209
            ...| ||.|.|..|.||||.|.|::.|.|.: ||.:....:..::.::....|...|...||:
Human   127 DCFS-YVLQSDTLLSSLTVRETLHYTALLAI-RRGNPGSFQKKVEAVMAELSLSHVADRLIGNYS 189

  Fly   210 -GDDKKVLSGGERKRLAFAVELLNNPVILFCDEPTTGLDSYSAQQLVATLYELAQKGTTILCTIH 273
             |.    :|.|||:|::.|.:||.:|.::..||||||||..:|.|:|..|.|||::...::.|||
Human   190 LGG----ISTGERRRVSIAAQLLQDPKVMLFDEPTTGLDCMTANQIVVLLVELARRNRIVVLTIH 250

  Fly   274 QPSSQLFDNFNNVMLLADGRVAFTGSPQHALSFFANHGYYCPEAYNPADFLIGVLATDPGYEQAS 338
            ||.|:||..|:.:.:|:.|.:.|.|:|...|.||.:.||.|||..||.||.:.:.:.|   .|:.
Human   251 QPRSELFQLFDKIAILSFGELIFCGTPAEMLDFFNDCGYPCPEHSNPFDFYMDLTSVD---TQSK 312

  Fly   339 QRSAQHLCDQFAVSSAAKQ----RDMLVNLE--IHMAQSGNFPFDTEVESFRGVAWYKRFHVVWL 397
            :|..:.......:.||.|:    ...|.|:|  .|:......||.|  :...||  :.:..|:..
Human   313 EREIETSKRVQMIESAYKKSAICHKTLKNIERMKHLKTLPMVPFKT--KDSPGV--FSKLGVLLR 373

  Fly   398 RASLTLLRDPTIQWLRFIQKIAMA-FIIGACFAGTTEPSQLGVQAVQGALFIMISENTYHPMYSV 461
            |.:..|:|:......|.:|.:.|. |::.......:...:..:|...|.|:..:....|..|.:.
Human   374 RVTRNLVRNKLAVITRLLQNLIMGLFLLFFVLRVRSNVLKGAIQDRVGLLYQFVGATPYTGMLNA 438

  Fly   462 LNLFPQGFPLFMRETRSGLYSTGQYYAANILALLPGMIIEPLIFVIICYWLTGLRSTFYAFG--- 523
            :||||....:..:|::.|||...|...|..|.:||..::..:||..:|||..||......||
Human   439 VNLFPVLRAVSDQESQDGLYQKWQMMLAYALHVLPFSVVATMIFSSVCYWTLGLHPEVARFGYFS 503

  Fly   524 ------------VTAMCVVLVMNVATACGCFFSTAFNSVPLAMAYLVPLDYIFMITSGIFIQVNS 576
                        :|.:.:.:|.|         ....||| :|:..:..:    ::.||....:..
Human   504 AALLAPHLIGEFLTLVLLGIVQN---------PNIVNSV-VALLSIAGV----LVGSGFLRNIQE 554

  Fly   577 LPVAFWWTQFLSWMLYANEAMTAAQWSGVQNITCFQESADLP-----CFHTGQDVLDK------- 629
            :|:.|....:.::..|.:|.:...::.|: |.||...:..:.     .|..|...::|
Human   555 MPIPFKIISYFTFQKYCSEILVVNEFYGL-NFTCGSSNVSVTTNPMCAFTQGIQFIEKTCPGATS 618

  Fly   630 -YSFNESNVYRNLLAMV 645
             ::.|...:|..:.|:|
Human   619 RFTMNFLILYSFIPALV 635

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
st	NP_524108.1	ABCG_EPDR	66..298	CDD:213180	81/218 (37%)
		3a01204	67..665	CDD:273361	169/602 (28%)
		ABC2_membrane	395..600	CDD:279410	47/220 (21%)
ABCG5	NP_071881.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..32
		ABCG_White	50..275	CDD:213201	81/218 (37%)
		3a01204	60..645	CDD:273361	169/602 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I7174
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3467
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48041
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.970