Protein Alignment st and ABCG4

DIOPT Version :9

• Sequence 1: NP_524108.1
• Gene: st / 39836
• FlyBaseID: FBgn0003515
• Length: 666
• Species: Drosophila melanogaster
• Sequence 2: NP_001135977.1
• Gene: ABCG4 / 64137
• HGNCID: 13884
• Length: 646
• Species: Homo sapiens
• Alignment Length: 671
• Identity: 196/671 - (29%)
• Similarity: 330/671 - (49%)
• Gaps: 86/671 - (12%)

  Fly    15 ERVEQHELQVMPVGSTIEVPSLDSTPKLSKRNSSERSLPLRSYSKWSPTEQGATLVWRDLCVYTN 79
            ::||.|            :........|.||::.:......|||    ..:|.  .||.
Human    38 KKVENH------------ITEAQRFSHLPKRSAVDIEFVELSYS----VREGP--CWRK------ 78

  Fly    80 VGGSGQRMKRIINNSTGAIQPGTLMALMGSSGSGKTTLMSTLAFRQPAGTVVQGDILING--RRI 142
                 :..|.::...:|......|:.:||.||:||:|.|:.||..:.:|  ::|.||:||  |.:
Human    79 -----RGYKTLLKCLSGKFCRRELIGIMGPSGAGKSTFMNILAGYRESG--MKGQILVNGRPREL 136

  Fly   143 GPFMHRISGYVYQDDLFLGSLTVLEHLNFMAHLRLDRRVSKEERRLIIKELLERTGLLSAAQTRI 207
            ..| .::|.|:.|||:.|..|||||.:...|:|:|..:  :|.::.::.|:|...||:|.:.||.
Human   137 RTF-RKMSCYIMQDDMLLPHLTVLEAMMVSANLKLSEK--QEVKKELVTEILTALGLMSCSHTRT 198

  Fly   208 GSGDDKKVLSGGERKRLAFAVELLNNPVILFCDEPTTGLDSYSAQQLVATLYELAQKGTTILCTI 272
            .      :||||:|||||.|:||:|||.::|.||||:||||.|..|:|:.:..|||.|.||:|||
Human   199 A------LLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLAQGGRTIICTI 257

  Fly   273 HQPSSQLFDNFNNVMLLADGRVAFTGSPQHALSFFANHGYYCPEAYNPADFLIGVLATDPG-YEQ 336
            ||||::||:.|:.:.:|:.|:..|.|...:.:.:....|.:||..:|||||:|.|.:.:.| ...
Human   258 HQPSAKLFEMFDKLYILSQGQCIFKGVVTNLIPYLKGLGLHCPTYHNPADFIIEVASGEYGDLNP 322

  Fly   337 ASQRSAQH-LCDQFAVSSAAKQRDMLVNL-----EIHMAQSGNFPFDTEVESFRGVAWYKRFHVV 395
            ...|:.|: ||......|:.::.::....     |:...:|..|...|          ..:|.::
Human   323 MLFRAVQNGLCAMAEKKSSPEKNEVPAPCPPCPPEVDPIESHTFATST----------LTQFCIL 377

  Fly   396 WLRASLTLLRDPTIQWLRFIQKIAMAFIIGACFAGTTEPSQLGVQAVQ-----GALFIMISENTY 455
            :.|..|::|||..:..|||:..:.:..:||..:.      .:|..|.:     |.||..:....:
Human   378 FKRTFLSILRDTVLTHLRFMSHVVIGVLIGLLYL------HIGDDASKVFNNTGCLFFSMLFLMF 436

  Fly   456 HPMYSVLNLFPQGFPLFMRETRSGLYSTGQYYAANILALLPGMIIEPLIFVIICYWLTGL---RS 517
            ..:...:..||....:||||..:..||...||.|..:|.:|..::.|:::..|.||:||.   .|
Human   437 AALMPTVLTFPLEMAVFMREHLNYWYSLKAYYLAKTMADVPFQVVCPVVYCSIVYWMTGQPAETS 501

  Fly   518 TFYAFGVTAMCVVLVMNVATACGCFFSTAFNSVPLAMAYLVPLDYI-FMITSGIFIQVNSLPVAF 581
            .|..|...|....|   ||.:.|.....|.||:.:| .::.|:..| .::.||.|:...::|...
Human   502 RFLLFSALATATAL---VAQSLGLLIGAASNSLQVA-TFVGPVTAIPVLLFSGFFVSFKTIPTYL 562

  Fly   582 WWTQFLSWMLYANEAMTAAQWSGVQ--NITCFQESADLPCFHTGQDVLDKYSFNESNVYRNLLAM 644
            .|:.:||::.|..|.:....: |::  ::||.:|...   |...|.:|......::.:|.:.| :
Human   563 QWSSYLSYVRYGFEGVILTIY-GMERGDLTCLEERCP---FREPQSILRALDVEDAKLYMDFL-V 622

  Fly   645 VGLYF-GFHLLGYYCLWRRAR 664
            :|::| ...||.|..|..|.:
Human   623 LGIFFLALRLLAYLVLRYRVK 643

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
st	NP_524108.1	ABCG_EPDR	66..298	CDD:213180	92/233 (39%)
		3a01204	67..665	CDD:273361	186/619 (30%)
		ABC2_membrane	395..600	CDD:279410	57/213 (27%)
ABCG4	NP_001135977.1	3a01204	44..646	CDD:273361	193/653 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141421
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.740