DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment st and AgaP_AGAP009468

DIOPT Version :9

Sequence 1:	NP_524108.1	Gene:	st / 39836	FlyBaseID:	FBgn0003515	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	XP_001688274.1	Gene:	AgaP_AGAP009468 / 5668142	VectorBaseID:	AGAP009468	Length:	585	Species:	Anopheles gambiae

Alignment Length:	630	Identity:	185/630 - (29%)
Similarity:	291/630 - (46%)	Gaps:	92/630 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 NSSERSLPLRSYSKWSPTEQGATLVWRDLCVYTNVGGSGQRMKRIINNSTGAIQPGTLMALMGSS 110
            |....:.||:::..       :|:.:|::...||       .|.|:.|.:|..|.|.|:||||.|
Mosquito    10 NRLSAATPLQNFVP-------STIRFRNVVYRTN-------EKEILGNVSGRFQHGRLVALMGPS 60

  Fly   111 GSGKTTLMSTLAFRQPAGTVVQGDILINGRRIGPFMHRISGYVYQDDLFLGSLTVLEHLNFMAHL 175
            |:||::|::.|:..|..|.:  |.:.|||..:.....| |.||.|:...|..|||.|.:.|...:
Mosquito    61 GAGKSSLLNVLSGAQVFGMI--GTVTINGEPVEENDPR-SVYVEQECPLLAFLTVQETMQFAVDM 122

  Fly   176 RLDRRVSKEERRLIIKELLERTGLLSAAQTRIGSGDDKKVLSGGERKRLAFAVELLNNPVILFCD 240
            ::.:...|..::..|.::||..||.:|..|.:.|      |||||::|||.||||:.||.|:..|
Mosquito   123 KMPQSSPKSAKQAKIDDILEMVGLDTARTTVVRS------LSGGEQRRLAVAVELITNPPIMLFD 181

  Fly   241 EPTTGLDSYSAQQLVATLYELAQKGTTILCTIHQPSSQLFDNFNNVMLLADGRVAFTGSPQHALS 305
            |||:||||.|:.|::|.|..||..|.||:||||||:|.||..|::|.||..||..:.|..:..|:
Mosquito   182 EPTSGLDSVSSTQVIAHLKSLAMSGRTIVCTIHQPASSLFQLFDDVYLLRQGRCLYAGPVEQMLT 246

  Fly   306 FFANHGYYCPEAYNPADFLIGVLATDPGYEQASQRSAQHLCDQFAVSSAAKQRDMLVNLEIHMAQ 370
            .||..|..|||.||||||.:..::       |:|..|..:..|            ||:.|:....
Mosquito   247 RFARVGLRCPEYYNPADFALESIS-------ANQPEAHRMLCQ------------LVDEEMREVN 292

  Fly   371 SGNFPFDTEVESFRG----------VAWYKRFHVVWLRASLTLLRDPTIQWLRFIQKIAMAFIIG 425
            :|.....|.:.:..|          .|.|.:.:.:..|:.::..||.....:|....:|:..:.|
Mosquito   293 AGAPSSPTTLAAQLGQGGKRIARYQTAGYYQLYTLLKRSVVSSARDEFFLKIRLGMHLALGLVFG 357

  Fly   426 ACF--AGTTEPSQLGVQAVQGALFIMISENTYHPMYSVLNLFPQGFPLFMRETRSGLYSTGQYYA 488
            |..  ||:....   |.|..|..|.:.:...:....||:| :.....:.::|..:..||...|:|
Mosquito   358 AVHYDAGSDAAK---VLANVGCFFQLFAFVYFTNAVSVVN-YADEVSVAIKEIANNWYSREAYFA 418

  Fly   489 ANILALLPGMIIEPLIFVIICYWLTGLRSTFYAF----GVTAMCVVLVMNVATACGCFFSTAFNS 549
            |.::..||..:..|...:.|.|:|||....:..|    ||.|:..|:..::....|..|.....:
Mosquito   419 AKLIHDLPLQLFCPSFLLAIVYYLTGQPLEWARFGMLLGVFAIGGVIGQSLGLIGGICFEVKMQN 483

  Fly   550 VPLAMAYLVPLDYIFMITSGIFIQVNSL--------PVAFWWTQFLSWMLYANEAMTAAQWSGVQ 606
            ..:|.|.:||:     :.||.|:....:        .|:|:..||       :.||.|.......
Mosquito   484 FFVANACIVPI-----LFSGFFVNAGDMIAILRPLSTVSFFRYQF-------HGAMQALYGYDRG 536

  Fly   607 NITCFQESADLPCFHTGQDVL------DKYSFNESNVYRNLLAMV 645
            ||.|.|    |.|::.....|      |:|.:..|.....:|.::
Mosquito   537 NIPCGQ----LYCYYKKPTTLLEQFDIDEYGYGTSIAKALVLVLI 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
st	NP_524108.1	ABCG_EPDR	66..298	CDD:213180	94/231 (41%)
		3a01204	67..665	CDD:273361	182/609 (30%)
		ABC2_membrane	395..600	CDD:279410	50/218 (23%)
AgaP_AGAP009468	XP_001688274.1	ABCG_EPDR	23..239	CDD:213180	94/238 (39%)
		3a01204	34..584	CDD:273361	180/599 (30%)
		ABC2_membrane	327..529	CDD:279410	50/217 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X52
TreeFam	0	0.000	Not matched by this tool.
	5	4.820