DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment st and AgaP_AGAP006380

DIOPT Version :9

Sequence 1:	NP_524108.1	Gene:	st / 39836	FlyBaseID:	FBgn0003515	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	XP_001688862.1	Gene:	AgaP_AGAP006380 / 5666864	VectorBaseID:	AGAP006380	Length:	1652	Species:	Anopheles gambiae

Alignment Length:	861	Identity:	163/861 - (18%)
Similarity:	285/861 - (33%)	Gaps:	309/861 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 EVPSLDSTPKLSKRNSSERSLPLRSYSKWSPTEQGATLVWRDLCVYTNVGGSG---QRMKRIINN 93
            :.||.|:   |.:.|.|..|    .|.:..|                 .|.:|   ::::::...
Mosquito   487 QTPSRDT---LFQANGSTES----RYIEQDP-----------------AGYAGVEIKQLRKVYKG 527

  Fly    94 STGAIQ-------PGTLMALMGSSGSGKTTLMSTL--AFRQPAGTVVQGDILINGRRIGPFMHRI 149
            :..|:.       ...:..|:|.:|:||||.||.|  .|...:||.     ||||..|...:..:
Mosquito   528 NKAAVDGLNLRMYENQISVLLGHNGAGKTTTMSMLTGVFAPTSGTA-----LINGHDIRTDIDGV 587

  Fly   150 S---GYVYQDDLFLGSLTVLEHLNFMAHLR--LDRRVSKEERRLIIKELLERTGLLSAAQTRIGS 209
            .   |...|.::....:||.|||.|.:.|:  ....||.|..|.:  :|||.|....|
Mosquito   588 RSSLGLCPQHNVLFDEMTVDEHLKFFSRLKGVPTEAVSGEIDRYL--KLLELTDKRDA------- 643

  Fly   210 GDDKKVLSGGERKRLAFAVELLNNPVILFCDEPTTGLDSYSAQQLVATLYELAQKGTTILCTIH- 273
              ..:.||||.:::||..:.|.....::..||||:|:|. ||::.:..|.:..::..|:|.:.|
Mosquito   644 --QSQTLSGGMKRKLAVGMALCGGSKVVLLDEPTSGMDP-SARRALWNLLQKEKQNRTMLLSTHF 705

  Fly   274 -QPSSQLFDNFNNVMLLADGRVAFTGSPQHALSFFANH----GY--YC-PEAYNPADFLIGVLA- 329
             ..:..|.|   .:.::|:|::...|||     ||...    ||  .| .:|......|:|:|.
Mosquito   706 MDEADVLGD---RIAIMAEGKLKAVGSP-----FFLKKTFGVGYRLICVKDARCDKQRLLGILRK 762

  Fly   330 --------TDPG----------YEQASQRSAQHLCDQFAVSSAAKQRDMLVNLEIHMAQSGNFPF 376
                    ||.|          |....||..:.:..|............|..:|....::|:..|
Mosquito   763 YIPDVTIDTDIGSELSFILKEDYLDVFQRLLEDIEQQMVSCGITSYGISLTTMEEVFLKAGSDSF 827

  Fly   377 D--------TEVESFRGVAWYKRFHVV-------------WLRASLTLLRDPTIQWLRFIQK--- 417
            |        |.||:........|.|::             .|:..|:.:|    .|::.:..
Mosquito   828 DETGTHTNGTVVETGSSEYALDRLHLLTGKELLFNQIQAQLLKKYLSSIR----AWVQLVMMFVI 888

  Fly   418 ----IAMAFII-GACFAGTTEPS-QLGVQAVQGALFIM--------------------------- 449
                :.|.||| .:..||...|: ::.:.:.:.|:.::
Mosquito   889 PIFFVCMTFIITRSISAGKDLPALEITIDSYEKAITVLERAGGETARVEAFQNMFTDRGELVTID 953

  Fly   450 -------------------------------------ISENTYHPMYSVLNL------------- 464
                                                 .:...:|.....|||
Mosquito   954 EDMTEYIVRKSIEDIAAVNTRYFVGATIRSGAPYVGWFNNKAFHTAPLALNLVYSAILQAQCTEC 1018

  Fly   465 --------FPQGFPLFMRETRSGL-------YSTG-----------QYY------AANILALLPG 497
                    .|......:::..:||       ::||           .:|      .|.:|..:.|
Mosquito  1019 QLHVINKPLPYRLDTQLKKLNTGLNAGFQLAFNTGFAMAFVAALYIMFYIKERTSRAKLLQFVSG 1083

  Fly   498 -----------------MIIEPLIFV-----------------------IICYWLTGLRSTF--- 519
                             .::..|:::                       ::.:....|..|:
Mosquito  1084 TNVTMFWLLAFMWDFTLFVLNSLVYIATVAIFQEEGWSTFEELGRAFLLLLFFGYATLPVTYLFS 1148

  Fly   520 YAFGVTAMCVVLVMNVATACGCFFSTAFNSVPLAMAYLVP----LDYIFMITSGIFIQ--VNSLP 578
            :.|.|:|...|.:|.|....|..|.||.|.:......||.    |:::||......:.  :|:|.
Mosquito  1149 FLFSVSATGFVRMMFVNVLSGAIFFTAVNVLKFDGIDLVEVAEGLEWVFMFFPNFVLSHGLNNLN 1213

  Fly   579 VAFWWTQFLSWMLYANEAMTAAQWSGVQNITCFQE---SADLPCFHTGQDVLDKYSFNESNVYRN 640
            .|            ::.|.:..::..:....|..:   |.|..|..     |:.:||....:.||
Mosquito  1214 AA------------SSTASSCKKFCDLLGAQCVVDDLCSVDARCCD-----LEVFSFGNVGIIRN 1261

  Fly   641 LL--AMVGLYFGFHLL 654
            ||  .::|. ..|.||
Mosquito  1262 LLFCVLIGT-VSFSLL 1276

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
st	NP_524108.1	ABCG_EPDR	66..298	CDD:213180	62/250 (25%)
		3a01204	67..665	CDD:273361	154/826 (19%)
		ABC2_membrane	395..600	CDD:279410	48/384 (13%)
AgaP_AGAP006380	XP_001688862.1	ABC2_membrane_3	<257..459	CDD:289468
		CcmA	516..796	CDD:224054	78/304 (26%)
		ABC_subfamily_A	516..734	CDD:213230	65/242 (27%)
		ABC2_membrane_3	879..1213	CDD:289468	42/333 (13%)
		ABC_subfamily_A	1333..1551	CDD:213230
		drrA	1340..1645	CDD:130256
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910