DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment st and abca3b

DIOPT Version :9

Sequence 1:	NP_524108.1	Gene:	st / 39836	FlyBaseID:	FBgn0003515	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	XP_009297489.1	Gene:	abca3b / 564344	ZFINID:	ZDB-GENE-050517-2	Length:	1703	Species:	Danio rerio

Alignment Length:	668	Identity:	140/668 - (20%)
Similarity:	247/668 - (36%)	Gaps:	166/668 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 STPKLS--KRNSSERSLPLRSYSKWSPTEQGATLVWRDLCVYTNVGGSGQRMKRIINNSTGAIQP 100
            |:|:::  |....|......|..::...|....:....:.....|...|.:.|..:.:.|..:..
Zfish   492 SSPRVAFLKEKEDEEDAEKASKGEFMEEEPAGLVAGVKIKRLAKVFKVGNKSKEAVRDLTLNMFE 556

  Fly   101 GTLMALMGSSGSGKTTLMSTLAFRQPAGTVVQGDILINGRRIGPFM---HRISGYVYQDDLFLGS 162
            |.:..|:|.:|:||||.:|.|....|..:   |...|||..|...|   .|..|...|.|:...:
Zfish   557 GQITVLLGHNGAGKTTTLSMLTGLFPPSS---GRAYINGYDICQDMALIRRSLGLCPQHDVLFDN 618

  Fly   163 LTVLEHLNFMAHLR--LDRRVSKEERRLIIKELLERTGLLSAAQTRIGSGDDK-----KVLSGGE 220
            |||.|||.|...|:  ...::..|..|:|                ||.:.:||     |.||||.
Zfish   619 LTVREHLLFYTQLKGYPREKIPGEVDRII----------------RILNLEDKRNAKCKTLSGGM 667

  Fly   221 RKRLAFAVELLNNPVILFCDEPTTGLDSYSAQQLVATLYELAQKGTTILCTIH-QPSSQLFDNFN 284
            :::|:..:.|:.:..::..||||:|:|. ||::....|.:..::|.|||.|.| ...:.|..  :
Zfish   668 KRKLSIGIALIGDSKVVMLDEPTSGMDP-SARRATWDLLQGEKRGRTILLTTHFMDEADLLG--D 729

  Fly   285 NVMLLADGRVAFTGSPQHALSFFANH---GYY---CPEAY-NPADF--LIGVLATDPGYEQASQR 340
            .:.::|.|.:...|||    .|..|.   ||:   ..:|: |.::.  |:.:...|...|.::..
Zfish   730 RIAIMASGELQCCGSP----LFLKNKYGAGYHMVIVKDAFCNVSEITRLVHMYVPDATLESSAGA 790

  Fly   341 SAQHLCDQFAVSSAAKQRDMLVNLEIHMAQSGNFPFDTEVESFRGVAWYKRFHVVWLR------A 399
            ...::..:   .|.::...:...||::..:.|...:...|.:         ...|:||      :
Zfish   791 ELSYILPK---ESTSRFELLFAELEMNRDELGIASYGASVTT---------MEEVFLRVGKLVDS 843

  Fly   400 SLTL--LRDPTIQWLRFIQKIAMAFIIGACFAGTTEPSQLGVQAVQGALFIMISE-------NTY 455
            ||.:  ::.|.:|:....:.........:..:|.|:.:.......      ||||       ||.
Zfish   844 SLDIQAIQLPALQYQHERRSHDWTMDDSSSISGMTDVTDFTDSCT------MISEDGSNIKLNTG 902

  Fly   456 HPMYSVLNLFPQGFPLFMRETRSGLYSTGQYYAANILALLPGMIIEPLIFVIICYWLT------- 513
            ..:|     ..|.:.:|::.   .|||...:      .::....:.||||.::...:.
Zfish   903 ARLY-----MQQFYAMFLKR---ALYSWRNW------KVMVAQFLVPLIFTVLALVVARSLPSSH 953

  Fly   514 ---GLRSTFYAFGVTAMCVVLVMNVATACGCFFSTAFNSVPLAMAYLVPLDYIFMITSGIFIQVN 575
               .||.....:|.|                       .||:|                  ::.|
Zfish   954 SSPQLRLALKQYGQT-----------------------HVPVA------------------VEAN 977

  Fly   576 SLPVAFWWTQFLSWMLYANEAMTAAQWSGVQNITCFQESADLPCFHTGQDVLDKYSFNESNVYRN 640
            :.|:|....:..:..|.:..|:.|      .|||.|.|.........|.      :|||.
Zfish   978 AGPLASLLAEIYTTQLPSQNAIAA------PNITDFSEYVLYNAQREGG------AFNEH----- 1025

  Fly   641 LLAMVGLYF-GFHLLGYY 657
              .:||..| ...::||:
Zfish  1026 --CVVGAAFRSSDVIGYF 1041

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
st	NP_524108.1	ABCG_EPDR	66..298	CDD:213180	65/242 (27%)
		3a01204	67..665	CDD:273361	134/637 (21%)
		ABC2_membrane	395..600	CDD:279410	37/229 (16%)
abca3b	XP_009297489.1	AAA	1..>95	CDD:333001
abca3b	XP_009297489.1	AAA	<122..1695	CDD:333001	140/668 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000