DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment st and CG9663

DIOPT Version :9

Sequence 1:	NP_524108.1	Gene:	st / 39836	FlyBaseID:	FBgn0003515	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	NP_608760.2	Gene:	CG9663 / 33541	FlyBaseID:	FBgn0031516	Length:	808	Species:	Drosophila melanogaster

Alignment Length:	778	Identity:	202/778 - (25%)
Similarity:	329/778 - (42%)	Gaps:	145/778 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 SKRIDVEAPE------RVEQHELQVMPVGSTIEVPS-------LDSTPKLSKRNSSERSL----- 52
            ||::..:.|.      :.:.|:..:....:|:...|       |.:||..|..|.|:||.
  Fly    54 SKKLSSKRPPHLTLNIKAKSHDAPLAETENTVLSTSESVYGTPLGATPVSSPANQSQRSQASQHS 118

  Fly    53 -PLRSYSKWS-------PTEQGATL----VWRDLCVYTNVGGSGQR-MKRIINNSTGAIQPGTLM 104
             ..|:.|..:       |.||..|:    :..:...||...|..|| .|.::...||..:.|.|.
  Fly   119 DESRNTSSTATSGGSIFPHEQYKTIKKINIGFENIRYTTKFGVFQRETKDVLMGLTGYFKSGELS 183

  Fly   105 ALMGSSGSGKTTLMSTLAFRQPAGTVVQGDILINGRR--IGPFMHRISGYVYQDDLFLGSLTVLE 167
            |::|.||:||:||::.|:.....|  ..||..:||.|  :..|...:: ::.||......|:|.|
  Fly   184 AVIGPSGAGKSTLLNILSGYTTYG--FTGDFRVNGNRRDLKAFKSNVA-FIRQDTSLQAFLSVKE 245

  Fly   168 HLNFMAHLRLDRRVSKEERRLIIKELLERTGLLSAAQTRIGSGDDKKVLSGGERKRLAFAVELLN 232
            .::|.|:|::...::..|:|..:|.:||..|:.....||.|.      ||||::||||.|:||:|
  Fly   246 AMHFAANLKIGTHMTHSEKRERVKCILEAIGMYENRHTRTGQ------LSGGQKKRLAIALELVN 304

  Fly   233 NPVILFCDEPTTGLDSYSAQQLVATLYELAQKGTTILCTIHQPSSQLFDNFNNVMLLADGRVAFT 297
            ||.:|..|||||||||:::.||:..|.:||.:|.|::|||||||:..|..|:::..:.:|:..:.
  Fly   305 NPPVLILDEPTTGLDSFTSNQLINLLKKLAIEGRTVICTIHQPSALTFAMFDHLYAIGEGKCIYA 369

  Fly   298 GSPQHALSFFANHGYYCPEAYNPADFLIGVLATDPGYEQASQRSAQHL----------------C 346
            |..|:.|.|......:|||:|||||:|:.:...|  |:.|.....:.|                .
  Fly   370 GGAQNLLPFLGALNLHCPESYNPADYLMEIATHD--YDTAEDNQLEKLVALMDNGRNEDYRQSKT 432

  Fly   347 DQFAVSSAAKQRDMLV---------------NLEIHMAQSGNFPFDTEVESFRGVAW-------- 388
            .:.|..:|.|:.|.|:               ::..|..|...|...|.:.......|
  Fly   433 ARVAQLAAMKKVDQLMAAGLITPVTAPVMSTSVPAHFMQGNTFKPLTPINELSSRVWDSQTAGIG 497

  Fly   389 ------------------------------------YKRFHVVWLRASLTLLRDPTIQWLRFIQK 417
                                                |::..::.:|..|.:.||.::..:||...
  Fly   498 NAGSCCKPKKKNKSRPAIELDPSHLCKRQNIYATPFYRQLSILLVRTFLLIWRDSSLTTMRFAIH 562

  Fly   418 IAMAFIIGACFAGTTEPSQLGVQAVQGA-----LFIMISENTYHPMYSVLNLFPQGFPLFMRETR 477
            :....:||..:.|      :|..|.|..     ||..|....|.....:|..||..||:..||..
  Fly   563 LITGILIGTLYFG------IGNDAAQTLNIFRYLFYTIMFIMYCAFSGILVKFPLEFPIVSREHF 621

  Fly   478 SGLYSTGQYYAANILALLPGMIIEPLIFVIICYWLTGLRSTFYAFGVTAMCV----VLVMNVATA 538
            :..||...||.|..||.||..||...:|::..|.:|......:.||:..:.|    ::..::..|
  Fly   622 NRWYSLRAYYVAITLADLPIQIICSALFIVPTYLMTQQPLELWRFGMFFLIVFVTALVSQSIGLA 686

  Fly   539 CGCFFSTAFNSVPLAMAYLVPLDYIFMITSGIFIQVNSLPVAFWWTQFLSWMLYANEAMTAAQWS 603
            .|...|....|: |...::.|    |:..||.|:.....||...|...:|::.|:.|..|.|.:.
  Fly   687 VGAALSLKLGSI-LGPFFICP----FLQFSGFFLMEKDAPVFLRWMFDISFLKYSLEGATMAIFG 746

  Fly   604 -GVQNITCFQESADLPC-FHTGQDVLDKYSFNESNVYRNLLAMVGLYFGFHLLGYYCLWRRAR 664
             ..:.:.|    .:|.| ....|.:|........|....|:.:.|:.....:|.:|.:..|.|
  Fly   747 YDREPLAC----NELYCHLRHPQFILKSLDMANGNYTLALIFLFGVLVFLRILAFYIMSFRLR 805

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
st	NP_524108.1	ABCG_EPDR	66..298	CDD:213180	85/238 (36%)
		3a01204	67..665	CDD:273361	183/691 (26%)
		ABC2_membrane	395..600	CDD:279410	57/213 (27%)
CG9663	NP_608760.2	ABCG_EPDR	145..370	CDD:213180	84/233 (36%)
		3a01204	149..808	CDD:273361	182/683 (27%)
		ABC2_membrane	540..743	CDD:279410	57/213 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438916
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	1	1.000	-	-		mtm14984
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48041
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
	8	7.850