DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment st and Abca15

DIOPT Version :9

Sequence 1:	NP_524108.1	Gene:	st / 39836	FlyBaseID:	FBgn0003515	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	NP_796187.2	Gene:	Abca15 / 320631	MGIID:	2388709	Length:	1668	Species:	Mus musculus

Alignment Length:	804	Identity:	159/804 - (19%)
Similarity:	272/804 - (33%)	Gaps:	278/804 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 NNSTGA--------IQPGTLMALMGSSGSGKTTLMSTLAFRQPAGTVVQGDILINGRRIGPFMHR 148
            ||:|..        :..|.:..|:|.:|:||:|.:|.|:...|.   ..|:..::|..|...|.:
Mouse   534 NNTTKVAIKDLSLNLYEGQVTVLLGHNGAGKSTTLSILSGLYPP---TSGEAYVHGEDISQHMDQ 595

  Fly   149 IS---GYVYQDDLFLGSLTVLEHLNFMAHLR-LDRRVSKEERRLIIK--ELLERTGLLSAAQTRI 207
            :.   |...|.:|....|||.|||.|...:: :.:::..||...::.  .|:|:....|
Mouse   596 VRNSLGLCPQQNLLFDHLTVSEHLYFYCRIKGVPQKMYLEETNNMLSAFNLMEKCDAFS------ 654

  Fly   208 GSGDDKKVLSGGERKRLAFAVELLNNPVILFCDEPTTGLDSYSAQQLVATLYELAQKGTTILCTI 272
                  |.||||.:::||..:.|:....:...||||:|:|..|.:.....|....|..|.:|.|.
Mouse   655 ------KSLSGGMKRKLAIIIALIGGSKVAILDEPTSGMDPASRRSTWDILQTYKQNRTILLTTH 713

  Fly   273 HQPSSQLFDNFNNVMLLADGRVAFTGSPQHALSFFANHGY------------YCP--------EA 317
            :...:.:..  :.:.::..|.:...||     |.|....|            ||.        .:
Mouse   714 YMDEADVLG--DRIAIMVRGTLRCCGS-----SVFLKRLYGVGSHLVMVKEPYCDIAEISKLIHS 771

  Fly   318 YNPADFLIGVLATDPGYE-----------------QASQRSAQHL-CDQFAVSSAAKQRDML--V 362
            |.|.    ..|.|:.|.|                 .|.:.:.::| ...|.||....:...|  .
Mouse   772 YVPT----ATLETNVGNELSFILPKEYTHRFEALFTALEENQENLGISSFGVSITTMEEVFLKVS 832

  Fly   363 NLE-----IHMAQS------GN------------FPFDTE-------------VESFRGV----- 386
            |||     |...||      ||            ||..:|             ::.||.:
Mouse   833 NLEDSKTDIEATQSPSVGSKGNKNGDVESSGRVGFPTQSEDQNIVFNTGCSLYLQQFRAMFMKRL 897

  Fly   387 -----AW------------------------YKRFH--------------VVWLRASLT------ 402
                 .|                        ||:..              .:|.:::||
Mouse   898 MYNWRNWRGILVQILGLIISTFLLLKSHEFRYKKIRQMNLDEYGQTIVPFSIWGKSNLTSSLLTH 962

  Fly   403 ---LLRDPTIQWLRFIQKIAMAFIIG--ACFAGTTEPSQLGVQAVQGALFIMISENTYH-PMYSV 461
               :|: |....|:.:|...:.::.|  .|.........:.|.|.:..|.::.:...|| |..|:
Mouse   963 LENMLK-PGNHQLKEVQGDLLKYLEGNDECVHLCVIALSIKVVANRVNLTVLFNNEAYHSPSLSL 1026

  Fly   462 -----------------LNLFPQGFPLFMRETRSGLYST-GQYYAANI---LALL-PGMII---- 500
                             :.:|.:..|...|:...|  || |:..|..|   :||| .|..|
Mouse  1027 TVLDNILFMSLSGSDASITVFNKPQPSPQRKEWPG--STDGKIVAFKIQLGMALLVSGFCILTVT 1089

  Fly   501 ------EPLIFV----IICYWLTGLRSTFYAFGVTAMCVVLVMNVATACGCFFS----------- 544
                  :.:.|:    |:.|||:.|......|.::. |.:|||...    |.|.
Mouse  1090 ERHNKTKHMQFLSGVSILVYWLSALVFDLIIFFISC-CFLLVMFKY----CKFDIYVTDYHILDT 1149

  Fly   545 ----TAFNSVPLAMAYLVPLDYIFMITSGIFIQV---------------------------NSLP 578
                |.|....:.:.||  |.::|..::..:|.:                           ||..
Mouse  1150 MLILTLFGWSAIPLTYL--LSFLFSKSNSAYINLLVFCYLSGTLSLLMDTIIEARISTIMSNSTQ 1212

  Fly   579 VAFWWTQFLSWMLYANEAMTAAQWSGV--QNITCFQESADLPCF-----HTGQDVLDKYSFNESN 636
             .|.....|.:.:| |.....::::.:  :.:.|.|:...|...     ||.:::   ||..:..
Mouse  1213 -TFLLNALLLFPMY-NLGKCISEYTVIYRKKMLCIQQKNALKYLNCSNKHTKKNI---YSLKKPM 1272

  Fly   637 VYRNLLAMVGLYFGFHLLGYYCLW 660
            :.:.|:||....|.|.||.::  |
Mouse  1273 LGKYLIAMSIAGFVFLLLIFF--W 1294

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
st	NP_524108.1	ABCG_EPDR	66..298	CDD:213180	53/219 (24%)
		3a01204	67..665	CDD:273361	159/804 (20%)
		ABC2_membrane	395..600	CDD:279410	56/294 (19%)
Abca15	NP_796187.2	ABC2_membrane_3	144..464	CDD:289468
		ABC2_membrane	<267..383	CDD:304374
		CcmA	522..831	CDD:224054	72/322 (22%)
		ABC_subfamily_A	522..743	CDD:213230	57/230 (25%)
		ABC2_membrane_3	<1009..1231	CDD:289468	45/232 (19%)
		CcmA	1354..1648	CDD:224054
		ABC_subfamily_A	1354..1575	CDD:213230
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000