DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment st and Abcg2

DIOPT Version :9

Sequence 1:	NP_524108.1	Gene:	st / 39836	FlyBaseID:	FBgn0003515	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	NP_852046.1	Gene:	Abcg2 / 312382	RGDID:	631345	Length:	657	Species:	Rattus norvegicus

Alignment Length:	609	Identity:	179/609 - (29%)
Similarity:	301/609 - (49%)	Gaps:	61/609 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 KRIINNSTGAIQPGTLMALMGSSGSGKTTLMSTLAFRQ-PAGTVVQGDILINGRRIGPFMHRISG 151
            |.|:::..|.::|| |.|::|.:|.||::|:..||.|: |.|  :.||:||||..........||
  Rat    60 KEILSDINGIMKPG-LNAILGPTGGGKSSLLDVLAARKDPRG--LSGDVLINGAPQPANFKCSSG 121

  Fly   152 YVYQDDLFLGSLTVLEHLNFMAHLRLDRRVSKEERRLIIKELLERTGLLSAAQTRIGSGDDKKVL 216
            ||.|||:.:|:|||.|:|.|.|.|||.:.:...|:...|..:::..||...|.:::|: ...:.:
  Rat   122 YVVQDDVVMGTLTVRENLQFSAALRLPKAMKTHEKNERINTIIKELGLDKVADSKVGT-QFTRGI 185

  Fly   217 SGGERKRLAFAVELLNNPVILFCDEPTTGLDSYSAQQLVATLYELAQKGTTILCTIHQPSSQLFD 281
            |||||||.:..:||:.:|.|||.|||||||||.:|..::..|..::::|.||:.:||||...:|.
  Rat   186 SGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFK 250

  Fly   282 NFNNVMLLADGRVAFTGSPQHALSFFANHGYYCPEAYNPADFLIGVLATDPGYEQASQRSAQHLC 346
            .|:::.|||.|::.|.|..|.||.:||:.||:|....|||||.:.|:..|......::....|..
  Rat   251 LFDSLTLLASGKLMFHGPAQKALEYFASAGYHCEPYNNPADFFLDVINGDSSAVMLNRGEQDHEA 315

  Fly   347 DQFAVSSAAKQRDMLVNL------------------EIHMAQ----SGNFPFDTEVESF-RGVAW 388
            :: ....:.:::.::.||                  ::.:||    |..|.....|.|| ..:.|
  Rat   316 NK-TEEPSKREKPIIENLAEFYINSTIYGETKAELDQLPVAQKKKGSSAFREPVYVTSFCHQLRW 379

  Fly   389 YKRFHVVWLRASLTLLRDPTIQWLRFIQKIAMAFIIGACFAG-TTEPSQLGVQAVQGALFIMISE 452
            ..|      |:...||.:|.....:.|..:.:..||||.:.| ..:|:  |:|...| :|..::.
  Rat   380 IAR------RSFKNLLGNPQASVAQLIVTVILGLIIGALYFGLKNDPT--GMQNRAG-VFFFLTT 435

  Fly   453 NTYHPMYSVLNLFPQGFPLFMRETRSGLYSTGQYYAANILA-LLPGMIIEPLIFVIICYWLTGLR 516
            |......|.:.||.....||:.|..||.|....|:...::: |||...:..:|:..:.|::.||:
  Rat   436 NQCFTSVSAVELFVVEKKLFIHEYISGYYRVSSYFFGKLVSDLLPMRFLPSVIYTCLLYFMLGLK 500

  Fly   517 STFYAFGVTAMCVVLV------MNVATACGCFFSTAFNSVPLAMAYLVPLDYIF-MITSGIFIQV 574
            .|..||.:....:::|      |.:|.|.|       .||......|:.:.::| |:.||:.:.:
  Rat   501 RTVEAFFIMMFTLIMVAYTASSMALAIAAG-------QSVVSVATLLMTISFVFMMLFSGLLVNL 558

  Fly   575 NSLPVAFWWTQFLSWMLYANEAMTAAQWSGVQ-----NITCFQESADLPCFHTGQDVLDKYSFNE 634
            .::.....|.|:.|...|...|:...::.|.:     |:|......:.....||.|.|.....:.
  Rat   559 RTIGPWLSWLQYFSIPRYGFTALQHNEFLGQEFCPGLNVTMNSTCVNSYTICTGNDYLINQGIDL 623

  Fly   635 S--NVYRNLLAMVGLYFGFHLLGY 656
            |  .::||.:|:..:...|..:.|
  Rat   624 SPWGLWRNHVALACMIIIFLTIAY 647

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
st	NP_524108.1	ABCG_EPDR	66..298	CDD:213180	85/210 (40%)
		3a01204	67..665	CDD:273361	179/609 (29%)
		ABC2_membrane	395..600	CDD:279410	53/213 (25%)
Abcg2	NP_852046.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
Abcg2	NP_852046.1	3a01204	46..651	CDD:273361	179/609 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335102
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.750