DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment st and Abca12

DIOPT Version :9

Sequence 1:	NP_524108.1	Gene:	st / 39836	FlyBaseID:	FBgn0003515	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	XP_237242.6	Gene:	Abca12 / 301482	RGDID:	1304586	Length:	2595	Species:	Rattus norvegicus

Alignment Length:	651	Identity:	136/651 - (20%)
Similarity:	228/651 - (35%)	Gaps:	205/651 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 KRIINNSTGAIQPGTLMALMGSSGSGKTTLMSTLA--FRQPAGTVVQGDILINGRRIGPFMHRI- 149
            |..::|.......|.:.:|:|.:|:||||.:|.|.  |...|||     |.:.|:.|...::.:
  Rat  1358 KTAVDNLNLNFYEGHITSLLGPNGAGKTTTISMLTGLFGATAGT-----IFVYGKDIKTDLNTVR 1417

  Fly   150 --SGYVYQDDLFLGSLTVLEHLNFMAHLRLDRRVSK---EERRLIIKELLERTGLLSAAQTRIGS 209
              .|...|.|:....||..|||.....:::.....|   ||    :|..|:.|||.|....|:|:
  Rat  1418 KNMGVCMQHDVLFSYLTTKEHLLLYGSIKVPHWTKKQLHEE----VKRTLKDTGLYSHRHKRVGT 1478

  Fly   210 GDDKKVLSGGERKRLAFAVELLNNPVILFCDEPTTGLDSYSAQQLVATLYELAQKGTTILCTIHQ 274
                  ||||.:::|:.::.|:....::..|||:||:|..|.:.:...:.:.....|.||.|.|.
  Rat  1479 ------LSGGMKRKLSISIALIGGSRVVILDEPSTGVDPCSRRSIWDVISKNKTARTIILSTHHL 1537

  Fly   275 PSSQLFDNFNNVMLLADGRVAFTGSPQHALSFFANHGYYCPEAYNPADFLIGVLATDPGYEQASQ 339
            ..:::..  :.:..|..|.:...|||           :|..||:.....|.......|..:
  Rat  1538 DEAEVLS--DRIAFLEQGGLRCCGSP-----------FYLKEAFGDGYHLTLTKKKSPNLD---- 1585

  Fly   340 RSAQHLCDQFAVSSAAKQRDMLVNLEIHMAQS-------GNF-----PFDTEVESFRGVAWYKRF 392
              ...:||..||::.         ::.|:.::       |..     ||.|:|..
  Rat  1586 --TNAICDTVAVTAM---------IQSHLPEAYLKEDIGGELVYVLPPFSTKVSG---------- 1629

  Fly   393 HVVWLRASLTLLR-----------------DPTIQ--WLRF-----------IQKIAMAFIIGAC 427
                  |.|:|||                 |.|::  :|..           ::.:....:....
  Rat  1630 ------AYLSLLRALDKGMGKLNIGCYGISDTTVEEVFLNLTKDSQKCGNMSLEHLTQRKVGNPS 1688

  Fly   428 FAGTTEPSQLGVQAVQGALFIMISENTYHPMYSVLNLFPQ--GFPLFMRETRSGLYSTGQYYAAN 490
            ..||:.|..|.|.          |.|.......||....:  ||.|.:::..:.|.....:...|
  Rat  1689 ANGTSTPDDLSVS----------SSNFTDRDDKVLTRSERLDGFGLLLKKIMAILIKRFHHTRRN 1743

  Fly   491 ILALLPGMIIEPLIFVIICYWLTGLRSTFYAFGVTAMCVVLVMNVATACGCFFSTAFNSVPLAMA 555
            ...|: ..::.|::||.....|..||.                            :.||.|
  Rat  1744 WKGLI-AQVVLPIVFVATAMGLGTLRD----------------------------SSNSYP---- 1775

  Fly   556 YLVPLDYIFMITSGIFIQVNSLPVAFWWTQFLSWMLYAN-----EAMTAAQWS--GVQNITCFQE 613
                   ..:|:..|:  .||...||          |||     .|:.:|.|:  |:.|: |...
  Rat  1776 -------ELLISPSIY--GNSEQTAF----------YANFDPSTNALVSALWNFPGIDNV-CLNT 1820

  Fly   614 SADLPC--------FHTGQDVLDKY-------------SFNESNVYRNLLAMVGLY--FGFHLLG 655
            | |..|        ::|..:.:|.:             .||.|..:|...:...:|  .|.|:..
  Rat  1821 S-DSQCLKKDNLGKWNTSGEAIDNFGVCSCSDNVQECPKFNYSPPHRRTYSSQVIYNLTGKHMEN 1884

  Fly   656 Y 656
            |
  Rat  1885 Y 1885

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
st	NP_524108.1	ABCG_EPDR	66..298	CDD:213180	58/217 (27%)
		3a01204	67..665	CDD:273361	136/651 (21%)
		ABC2_membrane	395..600	CDD:279410	42/241 (17%)
Abca12	XP_237242.6	ABC2_membrane_3	<1006..1267	CDD:289468
		NosY	<1108..1269	CDD:224196
		ZnuC	1346..1570	CDD:224046	64/239 (27%)
		ABC_subfamily_A	1350..1565	CDD:213230	62/234 (26%)
		ABC2_membrane_3	<1913..2174	CDD:289468
		CcmA	2253..2567	CDD:224054
		ABC_subfamily_A	2254..2477	CDD:213230
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000