DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment st and wht-5

DIOPT Version :9

Sequence 1:	NP_524108.1	Gene:	st / 39836	FlyBaseID:	FBgn0003515	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	NP_502352.1	Gene:	wht-5 / 178182	WormBaseID:	WBGene00008950	Length:	695	Species:	Caenorhabditis elegans

Alignment Length:	733	Identity:	199/733 - (27%)
Similarity:	334/733 - (45%)	Gaps:	113/733 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 DSKRIDVE---APERVEQHELQVMPVGSTIEVPSLDSTPKLSKRNSSERSLPLRSYSKWSPTEQG 66
            |||..:.|   .|:.||...|          :.|||..|....|:.:.:..|:......:|....
Worm     2 DSKSEEAEPLLKPKNVEDEGL----------ITSLDVDPTQKSRSPTPKPTPIPVLINDTPVASE 56

  Fly    67 ATLVWRDLC----------------------------------VYTNVGG-----SGQRMKRIIN 92
            ...|.::|.                                  |:.|:..     .|.| :.|:.
Worm    57 IEQVEKELAHSSERFRKPKTLSVTNDTESARIPSQVKTNAKKLVFQNIQAVVLKKKGVR-QEILK 120

  Fly    93 NSTGAIQPGTLMALMGSSGSGKTTLMSTLAFRQPAGTVVQGDILINGRR-IGPFMHRISGYVYQD 156
            ...|..:||.|..:|||||:|||||::.|..|........|||:||||. |...|.::|.||.||
Worm   121 KIDGVARPGELTFIMGSSGAGKTTLLNILTGRNLKNIETDGDIMINGRNMISNEMKKLSAYVQQD 185

  Fly   157 DLFLGSLTVLEHLNFMAHLRLDRRVSKEERRLIIKELLERTGLLSAAQTRIGSGDDKKVLSGGER 221
            |:|:|:|||.|.|.|.|.||....:...|...|:.|||....|.....|::|:..:|. ||.|||
Worm   186 DVFIGTLTVRETLRFAAKLRSPSALGATELDSIVDELLVMMSLKKCENTKVGTMTEKS-LSRGER 249

  Fly   222 KRLAFAVELLNNPVILFCDEPTTGLDSYSAQQLVATLYELAQKGTTILCTIHQPSSQLFDNFNNV 286
            ||||||.|:|.:|.||||||||:||||:.:.|::..|.:|..:|.|::|||||||:.::...:.:
Worm   250 KRLAFACEILTDPPILFCDEPTSGLDSFMSHQVIKALRQLTIEGKTVICTIHQPSTSVYHMADQL 314

  Fly   287 MLLADGRVAFTGSPQHALSFFANHGYYCPEAYNPADFLIGVLA-----TDPGYEQASQRSAQHLC 346
            :||:.|.||:.|..:...:||...||..|:..:..|..:.|::     |:..|   ::|..:.:.
Worm   315 ILLSQGHVAYAGPAKQVDAFFGRCGYPIPKFVSSPDHFMRVISHKSFETEDDY---NKRIEKIVL 376

  Fly   347 DQFAVSSAAKQRDMLVNLEIHMAQSGNFPFDTEVESFRGVAWYKRFHVVWLRASLTLLRDPTIQW 411
            :...:.........|.:......::..|.|..        .|..:|..::.|:|:.|.|:.::..
Worm   377 EHDIMKKEQSTHSTLSSSRREHPETAPFTFPR--------TWTAQFFFIFQRSSIQLWRERSVLL 433

  Fly   412 LRFIQKIAMAFIIGACFAGTTEPSQLGVQAVQGALFIMISENTYHPMYSV--LNLFPQGFPLFMR 474
            ::.||.:.|:.:||:.:.| .|..:..:.:.:|  |..:|....|.::.:  :.:|.:.:|:.:|
Worm   434 VKLIQTLIMSIMIGSTYYG-LEIDKKSLPSFKG--FAFVSVQMMHMLFMMPAMTVFWKDYPVVVR 495

  Fly   475 ETRSGLYSTGQYYAANILALLPGMIIEPLIFVIICYWLTGLRSTFYAFGVTAMCVVLVMNV---- 535
            |.::.:||...||.|...|.....::.|:||..|...:|.|     .:.|..:...|::|:
Worm   496 EFQANMYSPSAYYLAKTTADSIQYLVFPVIFSGILLGMTSL-----PYSVVIITNYLIINILLSL 555

  Fly   536 ---------ATACGCFFSTAFNSVPLAMAYLVPLDYIFMITSGIFIQVNSLPVAFWWTQFLSWML 591
                     |..|| ..:|....:|:.   .|||    |:..|..|...::|..|....::||..
Worm   556 NACSVGQSFAAMCG-HLATGMTVLPIV---CVPL----MVFGGFMITYEAIPWYFLPFAWVSWYK 612

  Fly   592 YANEAMTAAQW------SGVQ---NITCFQESADLPCFHTGQDVLDKYSFNESNVYRNLLAMVGL 647
            |..||:|...:      ||.:   ::...:.|.|..| .||.:.:...:|.|::::.:...::.:
Worm   613 YGFEAITIVYFNHNSTISGCESNSSVATLKMSIDSNC-TTGIEFIKAQAFEETHLWLDYTVILAV 676

  Fly   648 YFGFHLLGYYCL-WRRAR 664
            ...:.:||.... ||..|
Worm   677 ILFWKILGALLFTWRIRR 694

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
st	NP_524108.1	ABCG_EPDR	66..298	CDD:213180	101/271 (37%)
		3a01204	67..665	CDD:273361	184/668 (28%)
		ABC2_membrane	395..600	CDD:279410	53/219 (24%)
wht-5	NP_502352.1	3a01204	88..695	CDD:273361	182/637 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48041
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.920