DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment st and wht-3

DIOPT Version :9

Sequence 1:	NP_524108.1	Gene:	st / 39836	FlyBaseID:	FBgn0003515	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	NP_497825.2	Gene:	wht-3 / 175528	WormBaseID:	WBGene00007631	Length:	614	Species:	Caenorhabditis elegans

Alignment Length:	598	Identity:	196/598 - (32%)
Similarity:	319/598 - (53%)	Gaps:	25/598 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 TLVWRDLCVYTNVGGSGQRMKRIINNSTGAIQPGTLMALMGSSGSGKTTLMSTLAFRQPAGTVVQ 132
            |:.|.::.|.|......::.|:::|..:|..:||.::||||:||:||||||:.|..|...|....
Worm    38 TVTWENIEVKTRKKLFSKKQKQLLNRVSGIAKPGEMVALMGASGAGKTTLMNVLMCRNMKGLEKN 102

  Fly   133 GDILINGRRIGPFMHRISGYVYQDDLFLGSLTVLEHLNFMAHLRLDRRVSKEERRLIIKELLERT 197
            |.:.:||.:||..:..|||:..|.::|:.:|||.|:|...|.||:  :.:|..||..:.|::|..
Worm   103 GTVKVNGTKIGKEISLISGFAQQQEIFIPTLTVDEYLMIQARLRM--KANKHTRRERVDEIIEML 165

  Fly   198 GLLSAAQTRIGSGDDKKVLSGGERKRLAFAVELLNNPVILFCDEPTTGLDSYSAQQLVATLYELA 262
            .|.:....:||:....|.:||||.:||.||.|||:||.:||.||||:||||:.|..:|..|..||
Worm   166 RLQNCRDLKIGTPGLVKGISGGEARRLTFACELLSNPSLLFADEPTSGLDSFMAASVVQILKNLA 230

  Fly   263 QKGTTILCTIHQPSSQLFDNFNNVMLLADGRVAFTGSPQHALSFFANHGYYCPEAYNPADFLIGV 327
            ..|.|:   ||||:::||..|:.::.|:.|:.||.|:|..::.|||:.|:..|:.:||.:::...
Worm   231 NSGRTL---IHQPTAELFFQFDKIIFLSMGKTAFMGTPHESVKFFADCGHPIPKLFNPPEWIQSK 292

  Fly   328 LATDPGYEQASQRSAQHLCDQFAVSSAAKQRDMLVNLEIHMAQSGNFPFDTEVESFRGVAWYKRF 392
            |:..|..|..|:.:...:. :|...|...|:.:   :||.:..:...|...|...|     :...
Worm   293 LSVIPNNETKSRETIGKII-EFYEKSIIHQKSI---VEIRVIATTELPPYIENPGF-----FAET 348

  Fly   393 HVVWLRASLTLLRDPTIQWLRFIQKIAMAFIIGACFAGTTEP-SQLGVQAVQGALFIMISENTYH 456
            ..:..||.|.::|.|....::.|||:.|...||:.:  ..:| ...||:....||:.:|:|.|:.
Worm   349 GALLKRACLDVIRSPAQMRMKLIQKVVMGLFIGSLY--WQQPLDPRGVRNTNSALYFLIAELTFS 411

  Fly   457 PMYSVLNLFPQGFPLFMRETRSGLYSTGQYYAANILALLPGMIIEPLIFVIICYWLTGLRSTFYA 521
            .|:.::.......||..||...||:....||.:..|:.||...|:..:.::|.||:.||.||:..
Worm   412 TMFGIMTFMEHELPLIAREYHDGLFYVISYYISRFLSYLPLFTIDGALMIVISYWMIGLNSTWQQ 476

  Fly   522 FGVTAMCVVLVMNVATACGCFFSTAFNSVPLAMAYLVPLDYIFMITSGIFIQVNSLPVAFWWTQF 586
            ...:.:..|||...||:||.|.:..|.:..||:|:.||...:|.:.||::...|:.||...|.|:
Worm   477 VAKSILISVLVEQSATSCGLFLACLFETTSLAIAFAVPASGLFALLSGLYGNTNNFPVYIRWMQW 541

  Fly   587 LSWMLYANEAMTAAQWSGVQNITCFQESADLPCFHTGQDVLDKYSFNESNVYRNLLAMVGLYFGF 651
            .||..|..|.:...|||.|.|........:|        :|.::|||:.|...:::.:..:...|
Worm   542 TSWCRYGFEGLVVNQWSQVDNPKWDPFYREL--------ILKQFSFNKDNYQLDVIGLCSIVIFF 598

  Fly   652 HLLGYYCLWRRAR 664
            :|.||..|:.|.|
Worm   599 YLAGYIALFIRIR 611

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
st	NP_524108.1	ABCG_EPDR	66..298	CDD:213180	92/229 (40%)
		3a01204	67..665	CDD:273361	196/598 (33%)
		ABC2_membrane	395..600	CDD:279410	65/205 (32%)
wht-3	NP_497825.2	ABCG_EPDR	36..263	CDD:213180	92/229 (40%)
		3a01204	37..614	CDD:273361	196/598 (33%)
		ABC2_membrane	351..555	CDD:279410	65/205 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H104214
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53689
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.790