DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment st and Abcg8

DIOPT Version :9

Sequence 1:	NP_524108.1	Gene:	st / 39836	FlyBaseID:	FBgn0003515	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	NP_569098.2	Gene:	Abcg8 / 155192	RGDID:	620300	Length:	672	Species:	Rattus norvegicus

Alignment Length:	628	Identity:	175/628 - (27%)
Similarity:	286/628 - (45%)	Gaps:	76/628 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 LVWRDLCVYTNVGGSGQRMKRIINNSTGAIQPGTLMALMGSSGSGKTTLMSTLAFRQPAGTVVQG 133
            |.||.       .||.......|.|.:..::.|.::|::||:|.|:.||:..:..|...|.:..|
  Rat    73 LPWRS-------RGSQDSWDLGIRNLSFKVRSGQMLAIIGSAGCGRATLLDVITGRDHGGKMKSG 130

  Fly   134 DILINGRRIGP-FMHRISGYVYQDDLFLGSLTVLEHLNFMAHLRLDRRVSKEERRLIIKELLERT 197
            .|.|||:...| .:.:...:|.|.|..|.:|||.|.|.|:|.:||.:..|:.:|...:::::...
  Rat   131 QIWINGQPSTPQLIQKCVAHVRQQDQLLPNLTVRETLTFIAQMRLPKTFSQAQRDKRVEDVIAEL 195

  Fly   198 GLLSAAQTRIGSGDDKKVLSGGERKRLAFAVELLNNPVILFCDEPTTGLDSYSAQQLVATLYELA 262
            .|...|.||:|:...:.| |||||:|::..|:||.||.||..||||:||||::|..||.||..||
  Rat   196 RLRQCANTRVGNTYVRGV-SGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVRTLSRLA 259

  Fly   263 QKGTTILCTIHQPSSQLFDNFNNVMLLADGRVAFTGSPQHALSFFANHGYYCPEAYNPADFLIGV 327
            :....:|.::|||.|.:|..|:.|:|:..|...:.|..||.:.:|.:.||.||...|||||.:.:
  Rat   260 KGNRLVLISLHQPRSDIFRLFDLVLLMTSGTPIYLGVAQHMVQYFTSIGYPCPRYSNPADFYVDL 324

  Fly   328 LATD---PGYEQASQRSAQHLC----------DQFAVSSAAKQRDMLVNLEIHMAQSGNFPFDTE 379
            .:.|   ...|.|:...|:.|.          |.|...:.||..|...     .|.|.....||.
  Rat   325 TSIDRRSKEQEVATMEKARLLAALFLEKVQGFDDFLWKAEAKSLDTGT-----YAVSQTLTQDTN 384

  Fly   380 VESFRGVA-----WYKRFHVVWLRASLTLLRD-PTIQWLRFIQKIAMAFIIGACFAGTTEPSQLG 438
            .    |.|     ..::|..:..|......|| ||: ::...:...|:.|||..:.|..: ..|.
  Rat   385 C----GTAAELPGMIQQFTTLIRRQISNDFRDLPTL-FIHGAEACLMSLIIGFLYYGHAD-KPLS 443

  Fly   439 VQAVQGALFIMISENTYHPMYSVLNLFPQGFPLFMRETRSGLYSTGQYYAANILALLPGMIIEPL 503
            ...:...||::.:...::.:..|::.......|...|...|||:.|.|:.|.:|..||......:
  Rat   444 FMDMAALLFMIGALIPFNVILDVVSKCHSERSLLYYELEDGLYTAGPYFFAKVLGELPEHCAYVI 508

  Fly   504 IFVIICYWLTGLRSTFYAFGVTAMCVVLVMNVATACGCFFSTAFNSVPLAMAYLVPLDYI----- 563
            |:.:..||||.||.....|.:..|.:.||:   ..|        .::.||.:.::|..::
  Rat   509 IYGMPIYWLTNLRPGPELFLLHFMLLWLVV---FCC--------RTMALAASAMLPTFHMSSFCC 562

  Fly   564 ------FMITSGIFIQVNSLPVAFWWTQFLSWMLYANEAMTAAQWSG------VQNITCFQESAD 616
                  |.:|:|..|.:|:|.:...|...:|::.:....:...|::|      :.|:|     ..
  Rat   563 NALYNSFYLTAGFMINLNNLWIVPAWISKMSFLRWCFSGLMQIQFNGHIYTTQIGNLT-----FS 622

  Fly   617 LPCFHTGQDVLDKYSFNESNVYRNLLAMVGLYFGFHLLGYYCL 659
            :|    |..::.....|...:|...|.::|:..||..|.|..|
  Rat   623 VP----GDAMVTAMDLNSHPLYAIYLIVIGISCGFLSLYYLSL 661

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
st	NP_524108.1	ABCG_EPDR	66..298	CDD:213180	82/229 (36%)
		3a01204	67..665	CDD:273361	175/628 (28%)
		ABC2_membrane	395..600	CDD:279410	48/216 (22%)
Abcg8	NP_569098.2	ABCG_White	60..295	CDD:213201	82/229 (36%)
		3a01204	88..662	CDD:273361	170/606 (28%)
		ABC2_membrane	401..605	CDD:279410	48/216 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335100
Domainoid	1	1.000	92	1.000	Domainoid score	I7408
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53689
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.860