DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment st and AgaP_AGAP002051

DIOPT Version :9

Sequence 1:	NP_524108.1	Gene:	st / 39836	FlyBaseID:	FBgn0003515	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	XP_320996.5	Gene:	AgaP_AGAP002051 / 1281061	VectorBaseID:	AGAP002051	Length:	602	Species:	Anopheles gambiae

Alignment Length:	563	Identity:	126/563 - (22%)
Similarity:	229/563 - (40%)	Gaps:	114/563 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 IQPGTLMALMGSSGSGKTTLMSTLAFRQPAGTVVQGDILINGRRI--GPFMHRISGYVYQDDLFL 160
            :..|.:||::||.||||..|:..:|.|....:  :|.:|:||..:  ..|..| .|||.....|:
Mosquito    42 VHSGEVMAILGSKGSGKRALLDVIARRSDGSS--RGQVLLNGAPLTKSLFQQR-CGYVTHACDFI 103

  Fly   161 GSLTVLEHLNFMAHLRLDRRVSKEERRLIIKELLERTGLLSAAQTRIGSGDDKKV--LSGGERKR 223
            ..|||.:.|::...:......|.:.|:::             |...:.....|||  |:..|::|
Mosquito   104 PGLTVSQTLHYTPTILGGYLKSSKVRQVL-------------ADLALSQVSHKKVENLNISEKRR 155

  Fly   224 LAFAVELLNNPVILFCDEPTTGLDSYSAQQLVATLYELAQK-GTTILCTIHQPSSQLFDNFNNVM 287
            ||..::|:.:||:|..||||.|||..||..|::.|...|:| |..||.::.:|.|.:|...:..:
Mosquito   156 LAIGIQLVRDPVMLLLDEPTQGLDPLSAYLLISILSNSAKKTGCGILLSLEKPRSDVFPFLDRAL 220

  Fly   288 LLADGRVAFTGSPQHALSFFANHGYYCPEAYNPADFLIGVLATDPGYEQASQRSAQH---LCDQF 349
            .|..|...::|..:..|.:|...|:.||:..||..:.:.:...|.........|:|.   |.::|
Mosquito   221 FLCLGGAVYSGGTRAMLEYFHGIGFPCPQLENPLMYYLCLSTVDRRSRDRFLESSQQIEALVERF 285

  Fly   350 AVSSAAKQRDMLVNLEIHMAQSGNFPFDTEVESFRGVAWYKRFHVVWLR----------ASLTLL 404
            |      :...:....|:...||..|.     ::......|.:.:::||          |.:..|
Mosquito   286 A------RETPIPEAPINPIGSGKIPL-----AYGKPGELKVWGILYLRLLAATFSCGYAGMKAL 339

  Fly   405 RDPTIQWLRFIQKIAMAFIIGA--CFAGTTEPSQLGVQAVQGALFIMISENTYHPMYSVLNLFPQ 467
                     |::.:|:...:|.  .|.|.|.....|..:..|.:..:::.:....:::.::|||.
Mosquito   340 ---------FLRLLALPATMGLLWLFYGQTGDDAHGFFSKGGLILSVLALSYGVGIWATISLFPP 395

  Fly   468 GFPLFMRETRSGLYSTG--QYYAANILAL--------LPGMIIEPLIF-------VIICYWLTGL 515
            ....|.:|...||| ||  ...|.|.:::        :...::.||:.       :...|.|..|
Mosquito   396 WRKRFCQEYAEGLY-TGATMLIAYNTVSIPFSFISSAVAACVLYPLVLDPSNPDGMTFTYLLVAL 459

  Fly   516 RSTFYAFGVTAMCVVLVMNVATACGCFFSTAFNSVPLAMAYLVPLDYIFMI----TSGIFIQVNS 576
            .::|..  ...:||:.::.:.:......:|:               ||.::    .||.......
Mosquito   460 WTSFML--AEQLCVMFLLVMKSQLNAAIATS---------------YILIVCLTLASGTIRSTKG 507

  Fly   577 LPVAFWWTQFLSWM---------LYANEAMTAAQWSGVQNITC 610
            ||         .|:         .||:..:..|.:.| :.:.|
Mosquito   508 LP---------GWLQENAKGVHTKYASSLLHTATFLG-RKMNC 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
st	NP_524108.1	ABCG_EPDR	66..298	CDD:213180	62/204 (30%)
		3a01204	67..665	CDD:273361	126/563 (22%)
		ABC2_membrane	395..600	CDD:279410	42/246 (17%)
AgaP_AGAP002051	XP_320996.5	P-loop_NTPase	13..231	CDD:304359	62/204 (30%)
		CcmA	29..293	CDD:224054	76/272 (28%)
		YadH	321..528	CDD:223912	42/242 (17%)
		ABC2_membrane	333..513	CDD:279410	38/215 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820