DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment st and AgaP_AGAP008889

DIOPT Version :9

Sequence 1:	NP_524108.1	Gene:	st / 39836	FlyBaseID:	FBgn0003515	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	XP_319635.4	Gene:	AgaP_AGAP008889 / 1279856	VectorBaseID:	AGAP008889	Length:	656	Species:	Anopheles gambiae

Alignment Length:	720	Identity:	168/720 - (23%)
Similarity:	277/720 - (38%)	Gaps:	209/720 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 KRIINNSTGAIQPGTLMALMGSSGSGKTTLMSTLAFRQPAGTVVQGDILINGRRIGPFMHRISGY 152
            |.::|..:|..|.|.|.|:||.||:||::|::.|......|  |:|.:.....  |....::..|
Mosquito     1 KTVLNGVSGRFQSGELTAIMGPSGAGKSSLLNILTGYTTHG--VKGTLAFGSS--GSTNRKLCSY 61

  Fly   153 VYQDDLFLGSLTVLEHLNFMAHLRLDRRVS-----KEERRLIIKELLERTGLLSAAQTRIGSGDD 212
            :.|:| :|..|..:..:..||   .|.:||     :.|:..::.::|:...|....|||.||
Mosquito    62 ILQED-YLQPLFTVHEIMLMA---CDLKVSSDSLNRSEKLRLVDKILDTLHLSYCKQTRCGS--- 119

  Fly   213 KKVLSGGERKRLAFAVELLNNPVILFCDEPTTGLDSYSAQQLVATLYELAQKGTTILCTIHQPSS 277
               ||||:||||:.|:||::||.|||.|||||||||.|:...:..|..||::|.||:|||||||:
Mosquito   120 ---LSGGQRKRLSIALELIDNPPILFLDEPTTGLDSSSSLYTIKLLQGLAREGRTIVCTIHQPSA 181

  Fly   278 QLFDNFNNVMLLADGRVAFTGSPQHALSFFANHGYYCPEAYNPAD--------------FLI--- 325
            .:::.|::|.:||:|...:.||..:.:.:..:.|.:||..:|.||              |||
Mosquito   182 TVYEMFDHVYVLAEGHCVYQGSALNTVPYLRSVGLHCPAYHNAADYCKFLRCLCVCVLYFLIHPL 246

  Fly   326 ----------------------------------------------------------------- 325

Mosquito   247 PFFQQCWRSPTRSTATLPKRLPKPPPIRAGDWPRSSTGWAVVVVVVECRPHYPPVRRPTTAITTC 311

  Fly   326 -----------GVLATDPGYEQASQ-------------------RSAQHLCDQFAVSSAAKQ--- 357
                       |..|:.||...|.|                   .:.||    .||....|.
Mosquito   312 RLPGPPEGSGGGRTASRPGGPAARQDGGPEPAPTVRVCQTVDPDEALQH----SAVPGLGKSLGG 372

  Fly   358 RDMLVNLEIHMAQSGNFPFDTEVESFRGVAWYKRFHVVWLRASLTLLRDPTIQWLRFIQKIAMAF 422
            ::.:.....|..:  |||   .:..||                  .||..|:..|:....|..|.
Mosquito   373 KEYVPKPSTHFHE--NFP---PLPPFR------------------RLRLQTVTHLKLFVHIVCAI 414

  Fly   423 IIGACFAGTTEPSQLGVQAVQG----ALFIMISENTYHPMY--------SVLNLFPQGFPLFMRE 475
            :||..|..:      |:.|.:.    |.|::      |.:|        .||. :|....:..:|
Mosquito   415 VIGLLFGDS------GINATKSISNVASFMV------HILYLWYTTVMPGVLK-YPYEMNILKKE 466

  Fly   476 TRSGLYSTGQYYAANILALLPGMIIEPLIFVIICYWLTGLRSTFYAFGVTAMCVVLVMN--VATA 538
            :.:..|....|:.|::|..||..|...:::..|.|.:|........:  .....|||:|  ||..
Mosquito   467 SFNRWYKIRTYFVASMLTSLPVQIFFAIVYATIVYAMTYQPCELERY--LMFTAVLVLNTIVADG 529

  Fly   539 CGCFFSTAFNSVPLAMAYLVPLDYIFMITSGIFIQVNSLPVAFWWTQFLSWMLYANEAMTAAQWS 603
            .|.|..|..|.:.......:...::| :..|..|..:.:..|.....:||...|:.||:.
Mosquito   530 FGLFLGTFLNEINGTFIGAIMTCFMF-VFCGFLIMFSHMSDAMRGISYLSSHRYSFEALV----- 588

  Fly   604 GVQNITCFQES-ADLPC--------FHTGQDVLDKYSFNESNVYRNLLAMVGLYFGFHLLGYYCL 659
                :|.:.:| :||.|        :.....::.:......|...|::.:|..:....::|::.|
Mosquito   589 ----LTAYDDSRSDLVCPKDEMYCHYVKANTIMRELGVVSGNYLFNVVTLVVHFVAIKVVGFWTL 649

  Fly   660 WRRAR 664
            .|:.:
Mosquito   650 KRKLK 654

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
st	NP_524108.1	ABCG_EPDR	66..298	CDD:213180	81/214 (38%)
		3a01204	67..665	CDD:273361	168/720 (23%)
		ABC2_membrane	395..600	CDD:279410	48/218 (22%)
AgaP_AGAP008889	XP_319635.4	3a01204	1..654	CDD:273361	168/718 (23%)
		ABCG_EPDR	1..202	CDD:213180	81/214 (38%)
		ABC2_membrane	394..588	CDD:279410	49/227 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53689
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X52
TreeFam	0	0.000	Not matched by this tool.
	5	4.820