DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment st and AgaP_AGAP006379

DIOPT Version :9

Sequence 1:	NP_524108.1	Gene:	st / 39836	FlyBaseID:	FBgn0003515	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	XP_557048.3	Gene:	AgaP_AGAP006379 / 1276992	VectorBaseID:	AGAP006379	Length:	1643	Species:	Anopheles gambiae

Alignment Length:	711	Identity:	154/711 - (21%)
Similarity:	252/711 - (35%)	Gaps:	240/711 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 PTEQGATLVW-----RDLCVYTNV-GGSGQRMK------------------RIIN-----NSTGA 97
            |.|.|....|     ||......: .|||...|                  ||:|     ....|
Mosquito   461 PGEFGVAKPWNFLFTRDFWKRNRIEDGSGDWAKAESSPYFEQEPNIDRAGVRIVNLRKVYGKKVA 525

  Fly    98 IQ-------PGTLMALMGSSGSGKTTLMSTLA--FRQPAGTVVQGDILINGRRIGPFMHRIS--- 150
            ::       .|.:..|:|.:|:||||.||.|.  |...:||.     |:||..|...:..:.
Mosquito   526 VEGLNLNMFDGQITVLLGHNGAGKTTTMSMLTGMFSPTSGTA-----LVNGYDIRKDIEGVRFSL 585

  Fly   151 GYVYQDDLFLGSLTVLEHLNFMAHLR---LDRRVSKEERRLIIKELLERTGLLSAAQTRIGSGDD 212
            |...|.::....|||.|||.|.:.|:   .|:..::.|:.:.:.||.::..    ||:.
Mosquito   586 GLCPQHNVLFNELTVAEHLKFFSQLKGVPGDKTAAEIEKYVNLLELTDKRN----AQSH------ 640

  Fly   213 KKVLSGGERKRLAFAVELLNNPVILFCDEPTTGLDSYSAQQLVATLYELAQK---GTTILCTIH- 273
              .||||.:::|...:.|.....::..||||:|:|. ||::   .|::|.||   |.|::.:.|
Mosquito   641 --TLSGGMKRKLGVGIALCGGSRVVLLDEPTSGMDP-SARR---ALWDLIQKEKVGRTVILSTHF 699

  Fly   274 -QPSSQLFDNFNNVMLLADGRVAFTGSPQHALSFFANH----GY--------------------- 312
             ..:..|.|   .:.::|:|::...|||     ||...    ||
Mosquito   700 MDEADVLGD---RIAIMAEGKLRAIGSP-----FFLKKSLGAGYRLICVKEPTCDKKRVLEILKK 756

  Fly   313 YCPEAYNPADF---LIGVLATDPGYEQASQRSAQHLCDQFAVSSAAKQRDMLVNLEIHMAQSGNF 374
            |.||.....|.   |..||..|  |.:..|...:.|.|:......:.....|..:|....::|:.
Mosquito   757 YIPEVRIDTDIGTELSFVLRED--YLKVFQPMLEELEDKMRSCGISSYGISLTTMEEVFLRAGSD 819

  Fly   375 PFDTE------------------VESFRGVA---------------WYKRFHVVWLRASLTLLRD 406
            .|..|                  :.|..|:.               :||:| :..:|:.:||
Mosquito   820 SFQAEDSTNHTASGYIDMNENSDIYSLEGLTLLDGSKRLFQQINAQFYKKF-LTTIRSWITL--- 880

  Fly   407 PTIQWLRFIQKIAMAFIIGACFAGTTEPSQL---------------------GVQAVQGAL---- 446
             ::|.|..|..:.::::|   |..::....|                     |.::|..|.
Mosquito   881 -SMQMLIPILFVLLSYLI---FLNSSTGRDLPELKINLDRYSGSLTVLQTTDGFESVTAAFRDRF 941

  Fly   447 --------FIMISEN--TYHPMYSVLNLFPQGFPLFM----------RETRSGLYSTGQYYAANI 491
                    .|:|.|:  |:     :||...|....|.          |...:..::...|::|
Mosquito   942 RTEPNVHQLIVIDEDMTTF-----ILNKSSQDIATFNTRYWAGASLDRSVCTAWFNNKAYHSA-- 999

  Fly   492 LALLPGMIIEPLIFVIICYWLTGLRSTFYAFGVTAMCVVLVMN-------------VATACGCFF 543
             .|...||...|           |:|      :...|.:.|.|             :.|.....|
Mosquito  1000 -PLAVNMIYNAL-----------LQS------ICPNCELQVSNKPLPYRLDTQLQRLETGANAGF 1046

  Fly   544 STAFNSVPLAMAYLVPLDYIFMI----TSGIFIQ-VNSLPVAFWWTQFLSW--MLYANEAM 597
            ..|||: ..|||::..|..:|.|    |....:| |:.:.|..:||....|  |::...|:
Mosquito  1047 QLAFNT-GFAMAFVSALFILFYIKERTTRAKLLQFVSGVNVTLFWTISYLWDYMIFVLSAL 1106

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
st	NP_524108.1	ABCG_EPDR	66..298	CDD:213180	71/280 (25%)
		3a01204	67..665	CDD:273361	151/706 (21%)
		ABC2_membrane	395..600	CDD:279410	52/268 (19%)
AgaP_AGAP006379	XP_557048.3	ABC2_membrane_3	<246..455	CDD:289468
		CcmA	511..789	CDD:224054	80/308 (26%)
		ABC_subfamily_A	511..728	CDD:213230	68/245 (28%)
		ABC2_membrane_3	877..1214	CDD:289468	51/263 (19%)
		ABC_subfamily_A	1328..1546	CDD:213230
		drrA	1335..1636	CDD:130256
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910