DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment st and AgaP_AGAP002638

DIOPT Version :9

Sequence 1:	NP_524108.1	Gene:	st / 39836	FlyBaseID:	FBgn0003515	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	XP_312290.4	Gene:	AgaP_AGAP002638 / 1273324	VectorBaseID:	AGAP002638	Length:	776	Species:	Anopheles gambiae

Alignment Length:	493	Identity:	106/493 - (21%)
Similarity:	176/493 - (35%)	Gaps:	164/493 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 VMPVGSTIEVPS-----LDSTPKLSKRNSSERSLPLRSYSKWSPTEQGATLVWRDLCVYTNVGGS 83
            :.||.:....||     ||...:..|..|...::.:|        .|.|..|.|...:|    |:
Mosquito     8 IPPVATGSGQPSTTDTELDLAARRKKFMSQPSTVAIR--------RQQAVCVRRAHKIY----GT 60

  Fly    84 GQRMKRIINNSTGAIQPGTLMALMGSSGSGKTTLMSTLAFRQPAGTVVQGDILINGRRIGPFMHR 148
            .:....|::.....:..|::..|:|:||.|||||:|.:..|:...:   |:|.:.|.|.|.....
Mosquito    61 KKNPNVILDGLNMTVPKGSIYGLLGASGCGKTTLLSCIVGRRRLNS---GEIWVLGGRPGSRGSG 122

  Fly   149 IS----GYVYQDDLFLGSLTVLEHLNFMAHLRLDRRVSKEERRLIIKELLERTGLLSAAQTRIGS 209
            :.    ||:.|:....|..|:.|.|.:...:........:|:...:.:||:   |.:|::.
Mosquito   123 VPGPRVGYMPQEVALYGEFTIRETLIYFGWIYGMTTDQVDEKTDFLCKLLQ---LPNASRF---- 180

  Fly   210 GDDKKVLSGGERKRLAFAVELLNNPVILFCDEPTTGLDSYSAQQLVATLYELAQKG-TTILCTIH 273
               .|.||||:::|::.|..|||.|.:|..||||.|:|....|.:...|.|:.:.| ||::.|.|
Mosquito   181 ---VKNLSGGQQRRMSLAAALLNEPELLILDEPTVGVDPVLRQSIWDHLVEITKSGNTTVIVTTH 242

  Fly   274 QPSSQLFDNFNNVMLLADGRVAFTGSPQHALSFFANHGYYCPEAYNPADFLIGVLATDPGYEQAS 338
                          .:.:.|.|      |.:.......:...|  :|||.|             :
Mosquito   243 --------------YIEETRQA------HVIGLMRGGKFLAEE--SPADLL-------------A 272

  Fly   339 QRSAQHLCDQF----AVSSAAKQRDMLVNLEI---------------------HMAQSGNF---- 374
            |..|:.|.|.|    .:.:..|:|...:..|:                     |...||.|
Mosquito   273 QYQAESLEDVFLKLSVLQNMGKRRRSSIAQEVVEHVRIPAISNPALDLSPEEDHGEISGEFGDNI 337

  Fly   375 -----------------PFDTEVESFRGVAWYKRFHVVWLRASLTLLRDPTIQWLRFIQKI---- 418
                             |...|.::                      :.|.:::|:||:..
Mosquito   338 SMSSRGPDAVTPEIQAPPLPPEEDT----------------------KTPLVEYLKFIKPNHMRA 380

  Fly   419 --------------AMAFIIGA--------CFAGTTEP 434
                          .||||||.        |:|...:|
Mosquito   381 LIWKNFLWMWRNVGVMAFIIGLPVAQIILFCWAIGHDP 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
st	NP_524108.1	ABCG_EPDR	66..298	CDD:213180	63/236 (27%)
		3a01204	67..665	CDD:273361	96/445 (22%)
		ABC2_membrane	395..600	CDD:279410	13/66 (20%)
AgaP_AGAP002638	XP_312290.4	PQQ_ABC_ATP	48..286	CDD:274822	74/289 (26%)
		ABC_DR_subfamily_A	56..261	CDD:213197	61/241 (25%)
		ABC2_membrane_3	394..769	CDD:289468	9/25 (36%)
		ABC2_membrane	569..737	CDD:279410
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910