DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment st and abcg5

DIOPT Version :9

Sequence 1:	NP_524108.1	Gene:	st / 39836	FlyBaseID:	FBgn0003515	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	XP_031757398.1	Gene:	abcg5 / 100145776	XenbaseID:	XB-GENE-963936	Length:	662	Species:	Xenopus tropicalis

Alignment Length:	710	Identity:	186/710 - (26%)
Similarity:	310/710 - (43%)	Gaps:	119/710 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SDSKRIDVEAPERVEQHELQVMPV---------GSTIEVPSLDSTPKLSKR----NSSERSLP-- 53
            |....:|...||| :.:.||  ||         ||....||..|...:|..    ..|||..|
Frog     5 SQMNTMDQPQPER-QSYPLQ--PVGPDNASVSTGSDAMAPSAGSNCTISVEGICYTVSERIGPWW 66

  Fly    54 -LRS-YSKWSPTEQGATLVWRDLCVYTNVGGSGQRMKRIINNSTGAIQPGTLMALMGSSGSGKTT 116
             ::| |.||:                          ::|:.:.:..::.|.:||::|:|||||||
Frog    67 DIQSYYKKWT--------------------------RQILKDVSFFLESGQIMAILGNSGSGKTT 105

  Fly   117 LMSTLAFRQPAGTVVQGDILINGRRI--GPFMHRISGYVYQDDLFLGSLTVLEHLNFMAHLRLDR 179
            |:..::.|......:.|::.:||.::  ..|.:..| ||.|.|..|..|||.|.|.:.|.|.|.:
Frog   106 LLDAMSGRIGHKGTLLGEVYVNGSQLKKEQFQNCFS-YVLQHDTLLSYLTVRETLTYTALLALQK 169

  Fly   180 RVSKEERRLIIKELLERTGLLSAAQTRIGSGDDKKVLSGGERKRLAFAVELLNNPVILFCDEPTT 244
            . ||:..:..::.::....|:..|.:.|| |.....:|.|||:|::.|.:|:.:|.|:..|||||
Frog   170 H-SKQAIKEKVQSVMTELSLMQVANSVIG-GRIFNGISSGERRRVSIAAQLIQDPKIILLDEPTT 232

  Fly   245 GLDSYSAQQLVATLYELAQKGTTILCTIHQPSSQLFDNFNNVMLLADGRVAFTGSPQHALSFFAN 309
            ||||.:|.|:|..|.|||:|...::.:||||.|:||..|:.:.:::.|.:.|.|:|...:|||..
Frog   233 GLDSMTANQIVLLLSELARKDRIVIISIHQPRSELFRVFDKIAIMSLGELIFCGNPDEMISFFDG 297

  Fly   310 HGYYCPEAYNPADFLIGVLATDPGYEQASQRSAQHLCDQFAVSSAAKQRDMLVNL--EIHMAQSG 372
            .||.||:..||.||.:.:.:.|   .::.:|..:......|::||.|..|...|.  :|..|:..
Frog   298 CGYECPQHSNPFDFYVDLTSVD---TRSKERELETYSRSQAIASAYKNSDFYQNALEKIKTAKRN 359

  Fly   373 N----FPFDTEVESFRGVAWYKRFHVVWLRASLTLLRDPTIQWLRFIQKIAMAFIIGACFAGTTE 433
            .    .||..:    ...:...:.:|:..|....|.||.....:|..|.:.....|.......:.
Frog   360 RKEKLIPFKRK----EAPSELSKVYVLLRRTFRNLSRDKIGIVMRLSQNLIFGLFIAFFLIHLSN 420

  Fly   434 PSQLG-VQAVQGALFIMISENTYHPMYSVLNLFPQGFPLFMRETRSGLYSTGQYYAANILALLPG 497
            ....| ||...|.::..:....|..:.:.:.|||....:..:|.:.|||...|...|.|:.::|.
Frog   421 DILKGAVQDRLGFIYQCLGAPPYTGLLNAVALFPTLRAIGDQEGKDGLYQKWQMLLAYIIHIVPF 485

  Fly   498 MIIEPLIFVIICYWLTGLRSTFYAFGVTAMCVVLVMNVATACGCFFSTAFNSVPLAMAYLVPLDY 562
            .|:..:||....||:.||......||:                 ||:...  ||..|..|:.|..
Frog   486 SILSVVIFSGFIYWVIGLYPDILRFGI-----------------FFAVIL--VPHLMGELLTLAV 531

  Fly   563 I--------------------FMITSGIFIQVNSLPVAFWWTQFLSWMLYANEAMTAAQWSGVQN 607
            :                    .:|.|||...:..:|..|....::::..||:|.:...:::.: |
Frog   532 LGIVNNPNIVNAGVSLLNIAGILIGSGILRSLQEMPQVFQLLSYITYQKYASELLVINEFTDL-N 595

  Fly   608 ITCFQESADL----PC-FHTGQDVLD--------KYSFNESNVYRNLLAM-VGLYFGFHL 653
            .||...:|.:    .| |..|.:.::        :.:|:...:|..|.|| :|....|.:
Frog   596 FTCGGANASVGVNPECPFTQGNEFIEQTFPGAASRITFDFLMLYAFLPAMIIGCIISFKI 655

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
st	NP_524108.1	ABCG_EPDR	66..298	CDD:213180	75/233 (32%)
		3a01204	67..665	CDD:273361	163/630 (26%)
		ABC2_membrane	395..600	CDD:279410	48/225 (21%)
abcg5	XP_031757398.1	ABCG_White	60..286	CDD:213201	82/254 (32%)
abcg5	XP_031757398.1	3a01204	63..662	CDD:273361	168/649 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	95	1.000	Domainoid score	I7284
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48041
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020