DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment st and abcg8

DIOPT Version :9

Sequence 1:	NP_524108.1	Gene:	st / 39836	FlyBaseID:	FBgn0003515	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	NP_001108041.2	Gene:	abcg8 / 100136850	ZFINID:	ZDB-GENE-050517-41	Length:	684	Species:	Danio rerio

Alignment Length:	705	Identity:	191/705 - (27%)
Similarity:	319/705 - (45%)	Gaps:	92/705 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SDSDSKRIDVEAPERVE----------------------QHELQVMPVGSTIEVPSLDSTPKLSK 44
            |.|..|:|.|..|:..:                      ::||:|..:  ..||.:....|...|
Zfish    14 SSSYEKQIKVALPQNTQGRDILFSSPEEDSSLYFTYSGGRNELEVRNL--NYEVDTAAQIPWYEK 76

  Fly    45 RNSSERSLPLRSYSKWSPTEQGATLVWRDLCVYTNVGGSGQRMKRIINNSTGAIQPGTLMALMGS 109
              .||..:|      |.......|:: :||.::                    :..|.::|::||
Zfish    77 --LSEFKMP------WEMHSNKQTVI-KDLNLH--------------------VHSGQMLAVIGS 112

  Fly   110 SGSGKTTLMSTLAFRQPAGTVVQGDILINGR-RIGPFMHRISGYVYQDDLFLGSLTVLEHLNFMA 173
            ||.|||:|:..:..|...|::..|:|||||: .....:.:...:|.|||..|..|||.|.|.|:|
Zfish   113 SGCGKTSLLDIITCRDEGGSMNSGEILINGKPSTRSLVKKSIAHVRQDDRLLPHLTVRETLAFVA 177

  Fly   174 HLRLDRRVSKEERRLIIKELLERTGLLSAAQTRIGSGDDKKVLSGGERKRLAFAVELLNNPVILF 238
            .|||....|:::|...:.:::....|...|.||:|: :..:.:|||||:|::.||:||.||.||.
Zfish   178 KLRLPANFSQKQRDQRVDDVIAELRLRQCAHTRVGN-EYVRGVSGGERRRVSIAVQLLWNPGILI 241

  Fly   239 CDEPTTGLDSYSAQQLVATLYELAQKGTTILCTIHQPSSQLFDNFNNVMLLADGRVAFTGSPQHA 303
            .||||:||||::|..||.|||.||:....:|.::|||.|.:|..|:.|:||:.|...:.|..:..
Zfish   242 LDEPTSGLDSFTAHNLVITLYRLARGNRLVLLSVHQPRSDIFQLFDLVVLLSSGSAVYCGQAKDM 306

  Fly   304 LSFFANHGYYCPEAYNPADFLIGVLATDPGYEQASQRSAQHLCDQFAVSSAAKQRDMLVNLEIHM 368
            :|:|...||.||...||:|:.:.:::.|   .:..::.||  |.:.|...||:..:.:.|.|..|
Zfish   307 VSYFTTLGYPCPRYCNPSDYYVDLISID---RRTPEKEAQ--CLEKASMLAAQFLEKVKNNEDFM 366

  Fly   369 ------------AQSGNFPFDTEVESFRGVAWYK--------RFHVVWLRASLTLLRDPTIQWLR 413
                        |...:.|..:..||...|:..|        :|..:..|......||.....:.
Zfish   367 WKSEVCGPPALEAPQSSVPSVSMKESVITVSKQKDQLPGKVHQFTTLIRRQVFNDYRDLVTLVVH 431

  Fly   414 FIQKIAMAFIIGACFAGTTEPSQLGVQAVQGALFIMISENTYHPMYSVLNLFPQGF---PLFMRE 475
            .::.:.|:.:||..:.|.||.. |.:|... ||..||...|  |...||::..:..   .:...|
Zfish   432 GLEALLMSLLIGFLYFGCTEEG-LSIQDTV-ALLYMIGALT--PFAVVLDVIAKCHSERAMLYHE 492

  Fly   476 TRSGLYSTGQYYAANILALLPGMIIEPLIFVIICYWLTGLRSTFYAFGVTAMCVVLVMNVATACG 540
            ...|:||...|:.|.:|..||......|::.:..|||.||......|.:..:.|.|.:..:.:..
Zfish   493 LEDGMYSVTPYFFAKVLGELPEHCAFTLVYGVPIYWLAGLNVAPDRFLLNFLLVWLTVYCSRSMA 557

  Fly   541 CFFSTAFNSVPLAMAYLVPLDYIFMITSGIFIQVNSLPVAFWWTQFLSWMLYANEAMTAAQWSGV 605
            .|.:.|..::..:......|..:|.:|:|..|.:.::.:...|..::|:|.:..|.|...|:.|.
Zfish   558 LFVAAALPTLQTSSFMGNALFTVFYLTAGFVISLENMWMVASWFSYISFMRWGFEGMLQVQFRGT 622

  Fly   606 Q-NITCFQESADLPCFHTGQDVLDKYSFNESNVYRNLLAMVGLYFGFHLLGYYCL 659
            : .||.    .:|.....|..|::....|:..::...|.::.:...|.||.|..|
Zfish   623 RIPITI----GNLTVEFDGIKVVEMMKMNQYPLFSCYLVLIAVSLVFILLYYLSL 673

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
st	NP_524108.1	ABCG_EPDR	66..298	CDD:213180	84/232 (36%)
		3a01204	67..665	CDD:273361	174/618 (28%)
		ABC2_membrane	395..600	CDD:279410	49/207 (24%)
abcg8	NP_001108041.2	3a01204	47..674	CDD:273361	185/672 (28%)
		ABCG_White	72..301	CDD:213201	90/258 (35%)
		ABC2_membrane	413..617	CDD:279410	49/207 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574376
Domainoid	1	1.000	94	1.000	Domainoid score	I7419
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53689
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.860