DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43373 and Phlpp1

DIOPT Version :9

Sequence 1:	NP_001097622.2	Gene:	CG43373 / 39835	FlyBaseID:	FBgn0263131	Length:	1854	Species:	Drosophila melanogaster
Sequence 2:	NP_598582.3	Gene:	Phlpp1 / 98432	MGIID:	2138327	Length:	1687	Species:	Mus musculus

Alignment Length:	1158	Identity:	197/1158 - (17%)
Similarity:	344/1158 - (29%)	Gaps:	460/1158 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 PGAGSGGAVAGGV----------GGGATHIFRSLS---SESQKREWSKRLSLRGMRHGGAAGGPG 56
            |.:|:.|||.|..          ||..|.....:|   |:|...|.             .|||||
Mouse   252 PSSGTVGAVRGPARAPPADLPLPGGAWTRCAPRISPAPSDSSPGEL-------------FAGGPG 303

  Fly    57 GSGTSSLASSKEESKHRKFFSRSAS-------LRQAGSGGGGVGVGGVVGGSGSHQASMELHVPG 114
            ....:...:|..||     ||.|.|       |....|||||       ..|.|.:...:..:|.
Mouse   304 SPPRAPRPASDTES-----FSLSPSAESVSDRLDPYSSGGGG-------SSSSSEELEADPAMPH 356

  Fly   115 QEGRGTSSGAGSPQTQT--QPSTPKKSNWEVIEHFNTSAKGGKAVVSSSLIAAGI------TRCN 171
            :.||.......||:|..  ||..|...:       :|....|:.......:||..      |...
Mouse   357 RPGRPAQPRPPSPKTSALLQPKAPTGVD-------STGVIAGEGPGDDKAMAAAAPDVPLSTSGR 414

  Fly   172 IDESMDSTNSSS--------------TCHSPMIYQRDETQLLQPGDASNLE-------------- 208
            |.|::..|:..|              ....|:..|.|....|..|:...::
Mouse   415 IRETVQKTSPPSLYVQLHGETTRRLEADEKPLQIQNDYLFQLGFGELWRVQEEGMDSEIGCLIRF 479

  Fly   209 -ANNPMSSGGG-----GGTAN---GPVSPSISFWFRLNRIILRLCSTHQFKNLQVEMLYQRYFLR 264
             |..|.|:|..     .|..|   |.:...::.|.|...|:...|       |.|..      ::
Mouse   480 YAGKPHSTGSSERIQLSGMYNVRKGKMQLPVNRWTRRQVILCGTC-------LIVSS------VK 531

  Fly   265 MNQSNTTHILALLLALI---------LALSCT-------LLVFTT----LQLRRSTSLLL--EIS 307
            .:.|...|:|.|:...:         ||.|.:       .:.|.|    |:..|..|.:.  .||
Mouse   532 DSVSGKMHVLPLIGGKVEEVKKHQHCLAFSSSGPQSQTYYICFDTFTEYLRWLRQVSKVASQRIS 596

  Fly   308 EIGLD--------ANATVG-NLTTATMK------PPTLASS---DQMTRGSSIPLLALASNGSWA 354
            .:.|.        ||.... :||...:|      .|||.::   .::.|.:.:..|.|::|...|
Mouse   597 SVDLSCCSLEHLPANLFYSQDLTHLNLKQNFLRQTPTLPAARGLGELQRFTKLKSLNLSNNHLGA 661

  Fly   355 GNGAVG-----GELKSAHN------------HNIADFEADHNGQLVWRRQKRKHYRRLHKHRYKH 402
            ...||.     .||..:.|            .|:..|..|.|    :.:........:|:..|..
Mouse   662 FPSAVCSIPTLAELNVSCNALREVPAAVGDMQNLQTFLLDGN----FLQSLPAELESMHQLSYLG 722

  Fly   403 KSHQQHRTRYRMREKRSLQDAGLVKGGGIQTQLI-----------VDTATDDDADVYTVASDDDD 456
            .|..:......:.||.:..|...:.|..::|..:           ||...:   .:..:.:|:.|
Mouse   723 LSFNEFTDIPEVLEKLTAVDKLCMAGNCVETLRLQALRRMPHIKHVDLRLN---ILRKLMADEVD 784

  Fly   457 DVDGGRSAGSKHITYTPRVRD----------YNQIS--HAERDEVLNTSSNAGVATDNSDPPLGY 509
            .|        :|:|... :||          :|.|.  |.||::
Mouse   785 FV--------QHVTQLD-LRDNKLGDLDAMIFNNIEVLHCERNQ--------------------- 819

  Fly   510 GQLIPLILMQVDESVLVFLIVMLICGIVYAFLLCILSKPAMNEIFLVLVSYVILGTFLAIEVAVS 574
                              |:.:.:||.....|....::.|..:::.|
Mouse   820 ------------------LVTLNVCGYFLKALYASSNELAQLDVYPV------------------ 848

  Fly   575 YAMQPSKSFNGSACCIVLIYMTYTMLPLRLREALIGGILLSVVHLYTCLRLNAMQDEAVEMIHWE 639
                |:             |::|..:.....|:         |..:.|   .:.:.|.:::.|
Mouse   849 ----PN-------------YLSYMDVSRNCLES---------VPEWVC---ESRKLEVLDIGH-- 882

  Fly   640 ELLCTLVALLLANLTGVYTHWPKEKAQRKAFIETRQCIEARLRTQRENQQQERLLLSVLPRHVAM 704
            ..:|.|.|.|..|.:                  .|:.:....|..|..::.||..:.||
Mouse   883 NQICELPARLFCNSS------------------LRKLLAGHNRLARLPERLERTSVEVL------ 923

  Fly   705 EMKDDIAGQPRDTQFHKI------YIQRHENVSILFADICGFTSLSDQCTAEELVRLLNELFARF 763
                       |.|.::|      .:.:.:::..|.|......:|.....:||...:|.||:
Mouse   924 -----------DVQHNQITELPPNLLMKADSLRFLNASANKLETLPPATLSEETSSILQELY--- 974

  Fly   764 DRLAAEHHCL------------RIKLLGDCYYCVSGLPEPR--------------------PD-- 794
                ..::||            |:|:|...|..:...|..:                    |.
Mouse   975 ----LTNNCLTDKCVPLLTGHPRLKILHMAYNRLQSFPASKMAKLEELEEIDISGNKLKAIPTTI 1035

  Fly   795 -----------HAHC--------------AVEMGLDMIDAIALVREV------MAVNVNMRVGIH 828
                       |::|              .|::..:.:..|.|...:      :.:..|.|:.:.
Mouse  1036 MNCRRMHTVIAHSNCIEVFPEVMQLPEVKCVDLSCNELSEITLPENLPPKLQELDLTGNPRLALD 1100

  Fly   829 ------TGRVHCGVLGLVKWQFD------------VWSNDVTLANHMESGGIPGRVHI------- 868
                  ...:.|       ::.|            |||:..|     |:.|:..::.:
Mouse  1101 HKSLELLNNIRC-------FKIDQPSAGDASGAPAVWSHGYT-----EASGVKNKLCVAALSVNN 1153

  Fly   869 ---TKETL-KCLDGDYEVEV------------GKGNERNSYLKDHQIETYLIV 905
               .:|.| ...|||..|||            .:..::....:::.:.|::::
Mouse  1154 FRDNREALYGVFDGDRNVEVPYLLQCTMSDILAEELQKTKNEEEYMVNTFIVM 1206

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:292831	28/196 (14%)
		CYCc	686..881	CDD:214485	43/294 (15%)
		Guanylate_cyc	722..895	CDD:278633	40/284 (14%)
		DUF1053	<949..1005	CDD:283888
		CYCc	1259..1455	CDD:214485
		Guanylate_cyc	1285..1479	CDD:278633
Phlpp1	NP_598582.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..96
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	230..406		46/185 (25%)
		PH_PHLPP-like	491..587	CDD:270131	20/108 (19%)
		PH	511..592	CDD:278594	18/93 (19%)
		LRR_RI	581..885	CDD:238064	64/407 (16%)
		LRR_8	594..659	CDD:290566	15/64 (23%)
		LRR 1	594..615		5/20 (25%)
		leucine-rich repeat	597..617	CDD:275380	3/19 (16%)
		LRR 2	617..638		6/20 (30%)
		leucine-rich repeat	618..648	CDD:275380	7/29 (24%)
		LRR_8	647..726	CDD:290566	16/82 (20%)
		LRR 3	648..669		6/20 (30%)
		LRR 4	671..692		3/20 (15%)
		leucine-rich repeat	672..694	CDD:275380	3/21 (14%)
		LRR 5	694..715		4/24 (17%)
		leucine-rich repeat	695..717	CDD:275380	3/25 (12%)
		LRR 6	717..739		4/21 (19%)
		leucine-rich repeat	718..740	CDD:275380	4/21 (19%)
		LRR 7	740..760		3/19 (16%)
		leucine-rich repeat	741..764	CDD:275380	3/22 (14%)
		LRR 8	764..785		3/23 (13%)
		LRR_RI	768..1030	CDD:238064	58/403 (14%)
		leucine-rich repeat	768..788	CDD:275380	5/30 (17%)
		LRR 9	788..809		4/21 (19%)
		leucine-rich repeat	789..809	CDD:275380	3/20 (15%)
		leucine-rich repeat	810..851	CDD:275380	11/114 (10%)
		LRR 10	829..850		3/42 (7%)
		LRR 11	851..872		5/32 (16%)
		leucine-rich repeat	852..874	CDD:275380	4/33 (12%)
		LRR 12	874..895		6/22 (27%)
		leucine-rich repeat	875..897	CDD:275380	7/23 (30%)
		LRR_8	896..954	CDD:290566	12/92 (13%)
		LRR 13	897..918		4/38 (11%)
		leucine-rich repeat	898..919	CDD:275380	5/20 (25%)
		LRR 14	919..940		5/37 (14%)
		leucine-rich repeat	920..943	CDD:275380	5/39 (13%)
		LRR 15	943..964		3/20 (15%)
		leucine-rich repeat	944..967	CDD:275380	5/22 (23%)
		LRR 16	969..989		5/26 (19%)
		LRR_8	970..1028	CDD:290566	10/64 (16%)
		leucine-rich repeat	970..993	CDD:275380	5/29 (17%)
		LRR 17	993..1014		5/20 (25%)
		leucine-rich repeat	994..1017	CDD:275380	4/22 (18%)
		LRR 18	1017..1038		1/20 (5%)
		LRR 19	1040..1061		2/20 (10%)
		LRR 20	1062..1083		3/20 (15%)
		leucine-rich repeat	1063..1085	CDD:275380	3/21 (14%)
		LRR 21	1085..1106		2/20 (10%)
		PP2Cc	1124..1376	CDD:214625	15/88 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1414..1465
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1604..1687
		PDZ-binding	1685..1687
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900