DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43373 and Adcy7

DIOPT Version :9

Sequence 1:	NP_001097622.2	Gene:	CG43373 / 39835	FlyBaseID:	FBgn0263131	Length:	1854	Species:	Drosophila melanogaster
Sequence 2:	NP_445848.1	Gene:	Adcy7 / 84420	RGDID:	619966	Length:	1100	Species:	Rattus norvegicus

Alignment Length:	1091	Identity:	384/1091 - (35%)
Similarity:	575/1091 - (52%)	Gaps:	177/1091 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   512 LIPLILMQVD----ESVL---VFLIVMLICGIVYAFLLCILSKPAMNEIFLVLVSYVILGTFL-- 567
            |:.::....|    ::||   .|::.:.:...|..::.|:..:.......|.....:|||:.|
  Rat    49 LVSIVFSHEDLRRHQAVLGTAFFMLTLFVALYVLVYVECLAQRWLRVLALLTWACLMILGSVLMW 113

  Fly   568 -AIEVAVSYAMQPSKSFNGSACCIVLIYMTYTMLPLRLREALIGGILLSVVHL-----YTCLRLN 626
             ::| ..:||.:....|      :.::::.|.:|||..|.|:..|:..::.||     .|.....
  Rat   114 DSLE-NEAYAWEQVPFF------LFIVFVVYVLLPLSTRAAIAVGVASTISHLLVFGAVTRAFKT 171

  Fly   627 AMQDEAVEMIHWEELLCTLVALLLANLTGVYTHWPKEKAQRKAFIETRQCIEARLRTQRENQQQE 691
            :|....:.:    :||...|.||..|.||.:.....:.|.|..||.|.:||:.|.:.:.|.:|||
  Rat   172 SMSSTQLGL----QLLANAVILLGGNFTGAFHKHQLQDASRDLFIYTVKCIQIRRKLRVEKRQQE 232

  Fly   692 RLLLSVLPRHVAMEMKDDI-----AGQPR----DTQFHKIYIQRHENVSILFADICGFTSLSDQC 747
            .|||||||.|::|.||..|     .|..|    |..||.:|::||:|||||:|||.|||.|:..|
  Rat   233 NLLLSVLPAHISMGMKLAIIERLKEGGDRHYTPDNNFHSLYVKRHQNVSILYADIVGFTRLASDC 297

  Fly   748 TAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEPRPDHAHCAVEMGLDMIDAIAL 812
            :.:|||.:|||||.:||::|..:.|:|||:||||||||||||...|.||...|:||||:.:||..
  Rat   298 SPKELVVVLNELFGKFDQIAKANECMRIKILGDCYYCVSGLPVSLPTHARNCVKMGLDICEAIKQ 362

  Fly   813 VREVMAVNVNMRVGIHTGRVHCGVLGLVKWQFDVWSNDVTLANHMESGGIPGRVHITKETLKCLD 877
            |||...|:::||||||:|.|.|||:||.|||:||||:||:|||.||:.|:|||||||:.||..||
  Rat   363 VREATGVDISMRVGIHSGNVLCGVIGLRKWQYDVWSHDVSLANRMEAAGVPGRVHITEATLNHLD 427

  Fly   878 GDYEVEVGKGNERNSYLKDHQIETYLIVPGDIYRPHKKSRNRLQVNGNISKELRM---------- 932
            ..||||.|.|.:|:.|||:..|.|||::.....:|...|.:..:..|:.:.::|.
  Rat   428 KAYEVEDGHGEQRDPYLKEMNIRTYLVIDPRSQQPPLPSHHLSKPKGDATLKMRASVRVTRYLES 492

  Fly   933 ---------MGH-------------GTAQK------HTSKFGFGDSSESAKDP-EDEVNEYLMRA 968
                     :.|             |..||      |.:.    |.|.|.|.. ||:.::.::.|
  Rat   493 WGAARPFAHLNHRESVSSSEIPIPNGRRQKAIPLRRHRAP----DRSASPKGRLEDDCDDEMLSA 553

  Fly   969 IDARSIDH---LRAEHCQSLLLCFKDNVLERKYASEPDRMLCVYFYCSLLVLLGTSIMRLVVFQS 1030
            |:..|...   .:::...:....|.:...||:|...|.......|.|:.||.:...::.|:| ..
  Rat   554 IEGLSSTRPCCSKSDDFHTFGPIFLEKGFEREYRLVPIPRARYDFACASLVFVCILLVHLLV-MP 617

  Fly  1031 SLLTLALSTGAL-LLLGFLVFLVACHKINFQ--LPSDIKRFSLRIHSNRRISQLFAFASVALIVL 1092
            .:.||.||.|.: .|||.:  |..|....|.  ||:   |.:|:..|....:|.....|:.::.:
  Rat   618 RMATLGLSFGLVACLLGLV--LSFCFATEFSRCLPA---RSTLQAISESVETQPLLRLSLVVVTV 677

  Fly  1093 TTLLAMFQESGRQMELLQRRRFWLDVNGSISLNDTELNTKMYDAEEP----------------DC 1141
            .:||.:                 ..:|..::.|.        ..|:|                .|
  Rat   678 GSLLTV-----------------AIINMPLTFNP--------GPEQPGDNETSPLAARNRVGTPC 717

  Fly  1142 DFYLAYNTFLLLTLLSMMSCATYQVLRILLKLLLLLLASGSYM--------------ACSSNLYS 1192
            :. |.|.|  ...:|..::|:.:..:.:.||.:||.:|..:|:              :..:|...
  Rat   718 EL-LPYYT--CSCVLGFIACSVFLRMSLELKAMLLTVALVAYLLLFNLSPCWQVSGNSTETNSTH 779

  Fly  1193 RSREM--SQELANEEAL------------------LRYIIDSIFLFAFMLALIFHSHQTEATYRL 1237
            |:|.:  :::..|...|                  |:.:| :.:|..|...||..|.|.:...||
  Rat   780 RTRRLLSAEQSMNSHTLALGAQMTAPSPSSCLERDLKTMI-NFYLVLFYATLILLSRQIDYYCRL 843

  Fly  1238 DFIWKLQATEEKEDMEHLQAYNRKLLENILPVHVAEHFLSREKHLDDLYHEQCDSVCILFASIPN 1302
            |.:||.:..:|.|:.|.::..||.||||:||.|||.||:. :|..:|.||:..|.||::|||:|:
  Rat   844 DCLWKKKFKKEHEEFETMENVNRLLLENVLPAHVAAHFIG-DKAAEDWYHQSYDCVCVMFASVPD 907

  Fly  1303 FSEFYVELEGNNEGVECLRLLNEIIADFDELLSEERFRCIEKIKSTGATYMAASGLTA------N 1361
            |..||.|.:.|.||:|||||||||||||||||.:.:|..:||||:.|:|||||:||:.      .
  Rat   908 FKVFYTECDVNKEGLECLRLLNEIIADFDELLLKPKFSGVEKIKTIGSTYMAAAGLSVPSGHENQ 972

  Fly  1362 TCDRVNFSHVTAMADYALQLFDKIEEVNMHSFNNFRMRIGINIGPVVAGVIGACKPQYDIWGNAV 1426
            ..:|.:. |:..:.::::.|..|::.:|.||||:||:|:|||.|||:||||||.|||||||||.|
  Rat   973 DLERKHV-HIGVLVEFSMALMSKLDGINRHSFNSFRLRVGINHGPVIAGVIGARKPQYDIWGNTV 1036

  Fly  1427 NVASRMDSTGLVDHIQVTQEMQQILEGRGFELTCRGSVDVKGKGSMITYFL 1477
            ||||||:|||.:..||||:|...||:|.|:...|||.::|||||.:.|||:
  Rat  1037 NVASRMESTGELGKIQVTEETCTILQGLGYSCECRGLINVKGKGELRTYFV 1087

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:292831	60/216 (28%)
		CYCc	686..881	CDD:214485	117/203 (58%)
		Guanylate_cyc	722..895	CDD:278633	104/172 (60%)
		DUF1053	<949..1005	CDD:283888	14/59 (24%)
		CYCc	1259..1455	CDD:214485	112/201 (56%)
		Guanylate_cyc	1285..1479	CDD:278633	109/199 (55%)
Adcy7	NP_445848.1	AC_N	<21..251	CDD:318454	58/212 (27%)
		Guanylate_cyc	272..422	CDD:306677	92/149 (62%)
		DUF1053	487..593	CDD:399378	19/109 (17%)
		Guanylate_cyc	891..1087	CDD:306677	108/196 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.810