DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43373 and Adcy2

DIOPT Version :9

Sequence 1:	NP_001097622.2	Gene:	CG43373 / 39835	FlyBaseID:	FBgn0263131	Length:	1854	Species:	Drosophila melanogaster
Sequence 2:	NP_112269.2	Gene:	Adcy2 / 81636	RGDID:	619965	Length:	1095	Species:	Rattus norvegicus

Alignment Length:	1042	Identity:	402/1042 - (38%)
Similarity:	598/1042 - (57%)	Gaps:	117/1042 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   518 MQVDESVLVFLIVMLICGIVYAFLLCILSKPAMNEIFLV--LVSYVILGTFLAIEVAVSYAMQPS 580
            ::|::.|...:.|.....|.:|..:.:..:....::..|  ||.::.|       ||:.|...
  Rat    74 LEVEDHVAFLITVPTALAIFFAIFILVCIESVFKKLLRVFSLVIWICL-------VAMGYLFM-- 129

  Fly   581 KSFNGSACC-------IVLIYMTYTMLPLRLREALIGGILLSVVHLYTCLRLNAMQDEAVEMIHW 638
             .|.|:...       :.:|::.|||||..:|:|:|..||.|..|........:....|.|.:.|
  Rat   130 -CFGGTVSAWDQVSFFLFIIFVVYTMLPFNMRDAIIASILTSSSHTIVLSVYLSATPGAKEHLFW 193

  Fly   639 EELLCTLVALLLANLTGVYTHWPKEKAQRKAFIETRQCIEARLRTQRENQQQERLLLSVLPRHVA 703
             ::|..::..:..||.|.|.....|.|.::.:.:|..||::|::.:.|.:||||||||:||.|:|
  Rat   194 -QILANVIIFICGNLAGAYHKHLMELALQQTYRDTCNCIKSRIKLEFEKRQQERLLLSLLPAHIA 257

  Fly   704 MEMKDDI--------AGQPRDT-QFHKIYIQRHENVSILFADICGFTSLSDQCTAEELVRLLNEL 759
            ||||.:|        |||..:| .||.:|::||.|||||:|||.|||.|:..|:..|||.:||||
  Rat   258 MEMKAEIIQRLQGPKAGQMENTNNFHNLYVKRHTNVSILYADIVGFTRLASDCSPGELVHMLNEL 322

  Fly   760 FARFDRLAAEHHCLRIKLLGDCYYCVSGLPEPRPDHAHCAVEMGLDMIDAIALVREVMAVNVNMR 824
            |.:||::|.|:.|:|||:||||||||||||...|:||...|:|||||.:||..||:...|::|||
  Rat   323 FGKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAKNCVKMGLDMCEAIKKVRDATGVDINMR 387

  Fly   825 VGIHTGRVHCGVLGLVKWQFDVWSNDVTLANHMESGGIPGRVHITKETLKCLDGDYEVEVGKGNE 889
            ||:|:|.|.|||:||.|||:||||:|||||||||:||:||||||:..||:.|:|.|:||.|.|..
  Rat   388 VGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHISSVTLEHLNGAYKVEEGDGEI 452

  Fly   890 RNSYLKDHQIETYLIV--------PGDIYRP-----------------------------HKKSR 917
            |:.|||.|.::||.::        |..::||                             |...|
  Rat   453 RDPYLKQHLVKTYFVINPKGERRSPQHLFRPRHTLDGAKMRASVRMTRYLESWGAAKPFAHLHHR 517

  Fly   918 NRLQV-NGNISKELRMMGHGTAQKHTSKFGFGDSSESAKDPEDEVNEYLMRAIDARSIDH--LRA 979
            :.:.. ||.||.....||....|..|.:     :....|..|:|:||.:::|||..:...  |::
  Rat   518 DSMTTENGKISTTDVPMGQHNFQNRTLR-----TKSQKKRFEEELNERMIQAIDGINAQKQWLKS 577

  Fly   980 EHCQSLLLCFKDNVLERKYASEPDRMLCVYFYCSLLVLLGTSIMRLVVFQSSLLTLALSTGALLL 1044
            |..|.:.|.|.:..:|::|.:........|..|:.|:.|...|::::|...:.: |..|.||..|
  Rat   578 EDIQRISLLFYNKNIEKEYRATALPAFKYYVTCACLIFLCIFIVQILVLPKTSI-LGFSFGAAFL 641

  Fly  1045 -LGFLVF------LVAC-HKINFQLPSDIKRFSLRIHSNR---RISQLFAFASVALIVLTTLLAM 1098
             |.|::|      |:.| .|.:..|...:|  |..|.:||   |||  ....:.|:|:...:..|
  Rat   642 SLIFILFVCFAGQLLQCSKKASTSLMWLLK--SSGIIANRPWPRIS--LTIVTTAIILTMAVFNM 702

  Fly  1099 FQESGRQMELLQRRRFWLDVNGSISLNDTE---LNTKMYDAEEPDCDFYLAYNTFLLLTLLSMMS 1160
            |..|..:...|....   ..|.::|:.|.:   |:.:..        |:|.|  |:...:|.::|
  Rat   703 FFLSNSEETTLPTAN---TSNANVSVPDNQASILHARNL--------FFLPY--FIYSCILGLIS 754

  Fly  1161 CATYQVLRILLKLLLLLLASGSYMACSSNLYSRSRE-MSQELANEEALLRYI--IDSIFLFAFML 1222
            |:.:..:...||:|::::|...|.....:.::...: .||.|.....:.:.:  :.|:.|..|.:
  Rat   755 CSVFLRVNYELKMLIMMVALVGYNTILLHTHAHVLDAYSQVLFQRPGIWKDLKTMGSVSLSIFFI 819

  Fly  1223 ALIFHSHQTEATYRLDFIWKLQATEEKEDMEHLQAYNRKLLENILPVHVAEHFLSREKHLDDLYH 1287
            .|:....|:|...||||:||.:..:|:|::|.::..||.||||:||.|||||||:|....::|||
  Rat   820 TLLVLGRQSEYYCRLDFLWKNKFKKEREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYH 884

  Fly  1288 EQCDSVCILFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDELLSEERFRCIEKIKSTGATY 1352
            :..|.||::|||||:|.|||.|.:.|.||:||||||||||||||:|||:.:|..:||||:.|:||
  Rat   885 QSYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTY 949

  Fly  1353 MAASGLT-------ANTCDRVNFSHVTAMADYALQLFDKIEEVNMHSFNNFRMRIGINIGPVVAG 1410
            |||:||:       |...:| .:.|:..|.::|..|..|::.:|.||||:|::|:|||.|||:||
  Rat   950 MAATGLSAIPSQEHAQEPER-QYMHIGTMVEFAYALVGKLDAINKHSFNDFKLRVGINHGPVIAG 1013

  Fly  1411 VIGACKPQYDIWGNAVNVASRMDSTGLVDHIQVTQEMQQILEGRGFELTCRGSVDVKGKGSMITY 1475
            ||||.|||||||||.|||||||||||::|.||||:|...||:..|:..||||.::|||||.:.||
  Rat  1014 VIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLILQTLGYTCTCRGIINVKGKGDLKTY 1078

  Fly  1476 FL 1477
            |:
  Rat  1079 FV 1080

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:292831	62/214 (29%)
		CYCc	686..881	CDD:214485	123/203 (61%)
		Guanylate_cyc	722..895	CDD:278633	106/172 (62%)
		DUF1053	<949..1005	CDD:283888	15/57 (26%)
		CYCc	1259..1455	CDD:214485	119/202 (59%)
		Guanylate_cyc	1285..1479	CDD:278633	116/200 (58%)
Adcy2	NP_112269.2	AC_N	<37..264	CDD:318454	58/200 (29%)
		Guanylate_cyc	285..469	CDD:306677	111/183 (61%)
		DUF1053	499..603	CDD:399378	25/108 (23%)
		Guanylate_cyc	882..1081	CDD:306677	116/200 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.810