DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43373 and Gucy2d

DIOPT Version :9

Sequence 1:	NP_001097622.2	Gene:	CG43373 / 39835	FlyBaseID:	FBgn0263131	Length:	1854	Species:	Drosophila melanogaster
Sequence 2:	NP_077356.1	Gene:	Gucy2d / 79222	RGDID:	620438	Length:	1108	Species:	Rattus norvegicus

Alignment Length:	761	Identity:	167/761 - (21%)
Similarity:	266/761 - (34%)	Gaps:	256/761 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   793 PDHAHCAVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCGVLGLVKWQFDVWSNDVTLANHM 857
            |...|.|:.....|  |.:.:||:...||.:.:|:.                        ||...
  Rat   569 PGEHHMAIRPATKM--AFSKLRELRHENVALYLGLF------------------------LAGTA 607

  Fly   858 ESGGIPGR-------VHITKETLKCLDGDYEVEVGKGNERNSYLKDHQIETYLIVPGDIYRPHK- 914
            :|...||.       .|..:.:|..|....:::: ....::|.|.|       ::.|..|..|:
  Rat   608 DSPATPGEGILAVVSEHCARGSLHDLLAQRDIKL-DWMFKSSLLLD-------LIKGMRYLHHRG 664

  Fly   915 ------KSRNRLQVNGNISKELRMMGHG---TAQKHTSKFGFGDSSESAKDPEDEVNEYLMRAID 970
                  ||||.: |:|....::...|||   .||:...:      ..||:|......|.|
  Rat   665 VAHGRLKSRNCV-VDGRFVLKVTDHGHGRLLEAQRVLPE------PPSAEDQLWTAPELL----- 717

  Fly   971 ARSIDHLRAEHCQSLLLCFKDNVLERKYASEPDRMLCVYFYCSLLVLLGTSIMRLVVFQSSLLTL 1035
                               :|..|||:.                                   ||
  Rat   718 -------------------RDPALERRG-----------------------------------TL 728

  Fly  1036 ALSTGALLLLGFLVFLVACHKINFQLPSDIKRFSLRIHSNRRISQLFAFASVALIVLTTLLAMFQ 1100
            |   |.:..||.::..|.|....:                            |::.||
  Rat   729 A---GDVFSLGIIMQEVVCRSTPY----------------------------AMLELT------- 755

  Fly  1101 ESGRQMELLQRRRFWLDVNGSISLNDTELNTKMYDAEEPDCDFYLAYNTFLLLTLLSMMSC-ATY 1164
                ..|::||.|                      :..|.|...::.:...:..:..|..| |.:
  Rat   756 ----PEEVIQRVR----------------------SPPPLCRPLVSMDQAPMECIQLMAQCWAEH 794

  Fly  1165 QVLRILLKLLLLLLASGSYMACSSNLY-SRSREMSQELANEEALLRYIIDSIFLFAFMLALIFHS 1228
            ..||..:.|...|. .|......:|:. |..|.:.|..:|.|.|:|
  Rat   795 PELRPSMDLTFDLF-KGINKGRKTNIIDSMLRMLEQYSSNLEDLIR------------------- 839

  Fly  1229 HQTEATYRLDFIWKLQATEEKEDMEHLQAYNRKLLENILPVHVAEHFLSREKHLDDLYHEQCDSV 1293
                              |..|::|..:....:||..:||..||| .|.....::..|.|:   |
  Rat   840 ------------------ERTEELEQEKQKTDRLLTQMLPPSVAE-ALKMGTSVEPEYFEE---V 882

  Fly  1294 CILFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDELLSEERFRCIEKIKSTGATYMAASGL 1358
            .:.|:.|..|:    .:...:|.:|.:.|||::...||.::....   :.|:::.|..||.||||
  Rat   883 TLYFSDIVGFT----TISAMSEPIEVVDLLNDLYTLFDAIIGSHD---VYKVETIGDAYMVASGL 940

  Fly  1359 TANTCDRVNFSHVTAMADYALQLFDKIEEVNMHSFNN--FRMRIGINIGPVVAGVIGACKPQYDI 1421
            ......|    |...:|:.:|.:...:....|.....  .|:|||::.||.||||:|...|:|.:
  Rat   941 PQRNGQR----HAAEIANMSLDILSAVGSFRMRHMPEVPVRIRIGLHSGPCVAGVVGLTMPRYCL 1001

  Fly  1422 WGNAVNVASRMDSTGLVDHIQVTQEMQQILEG--RGFELTCRGSVDVKGKGSMITYFLKGR---- 1480
            :|:.||.||||:||||...|.|.....:||..  :||::.|||..::||||...||:|.||
  Rat  1002 FGDTVNTASRMESTGLPYRIHVNMSTVRILRALDQGFQMECRGRTELKGKGVEDTYWLVGRVGFN 1066

  Fly  1481 RPI--------DAKELELAKTEVEPPKTLTLAKEPEKLDSGTATEK 1518
            :||        .|....::..|:.|.:    .|:.||...|..|.|
  Rat  1067 KPIPKPPDLQPGASNHGISLQEIPPER----RKKLEKARPGQFTGK 1108

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:292831
		CYCc	686..881	CDD:214485	18/94 (19%)
		Guanylate_cyc	722..895	CDD:278633	19/108 (18%)
		DUF1053	<949..1005	CDD:283888	9/55 (16%)
		CYCc	1259..1455	CDD:214485	62/199 (31%)
		Guanylate_cyc	1285..1479	CDD:278633	66/197 (34%)
Gucy2d	NP_077356.1	PBP1_sensory_GC_DEF-like	58..434	CDD:380594
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	520..552
		PK_GC-2D	540..814	CDD:270945	69/409 (17%)
		HNOBA	<823..868	CDD:400168	16/82 (20%)
		CYCc	848..1039	CDD:214485	63/205 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1069..1108		9/42 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810