DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43373 and Gucy2g

DIOPT Version :9

Sequence 1:	NP_001097622.2	Gene:	CG43373 / 39835	FlyBaseID:	FBgn0263131	Length:	1854	Species:	Drosophila melanogaster
Sequence 2:	NP_001074545.1	Gene:	Gucy2g / 73707	MGIID:	106025	Length:	1100	Species:	Mus musculus

Alignment Length:	752	Identity:	172/752 - (22%)
Similarity:	268/752 - (35%)	Gaps:	246/752 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   836 VLGLVKWQF---------DVW----SNDVTL--ANHMESGGIP-GRVHIT-----KETLKCLDGD 879
            :.||:.|:.         |.|    .:.:||  .:.:...|.| .|.:::     |.:..|
Mouse   497 ITGLMLWRLRGKVQSHPGDTWWQIRYDSITLLPQHKLSHRGTPVSRRNVSDTSTVKASADC---- 557

  Fly   880 YEVEVGKGNERNSYLKDHQIETYLIVPGDIYRPHKKSRNRLQVNGNISKELRMMGHGTAQKHTSK 944
                       .|.:|.||.|.....|..:|:            ||               ..:.
Mouse   558 -----------GSLVKRHQDEELFFAPVGLYQ------------GN---------------QVAL 584

  Fly   945 FGFGDSSES-AKDPEDEVNEYLMRAIDARSIDHLRAEHCQSLLLCFKDNVLERKY---------A 999
            ...||.:|: .|.|.                  :|.|.|   |:|      |.|:         .
Mouse   585 CYIGDEAEAWVKKPT------------------VRREVC---LMC------ELKHENIVPFFGVC 622

  Fly  1000 SEPDRMLCVYFYC---SLLVLLGTSIMRL-VVFQSSLLTLALSTGALLLLGFLVFLVACHKINFQ 1060
            :||..:..|..||   ||..::..|...: .:|:.| ....:..|.|.|.|
Mouse   623 TEPPNICIVTQYCKKGSLQDVMRNSDHEIDWIFKLS-FAYDIVNGLLFLHG-------------- 672

  Fly  1061 LPSDIKRFSLRIHSNRRISQLFAFASVALIVLTTLLAMFQESGRQMELLQRRRFWLDVNGSISLN 1125
                   ..||.|.|.:.|....                 :|..|:: |.....|...:||
Mouse   673 -------SPLRSHGNLKPSNCLV-----------------DSHMQLK-LSGFGLWEFKHGS---- 708

  Fly  1126 DTELNTKMYDAEEPD-CDFYLAYNTFLLLTLLSMMSCATYQ----VLRILLKLLLLLLASGSY-- 1183
                ..:.|:.|..| .:.|  :....||.|.......|.|    ...|||:.|:...|.|.:
Mouse   709 ----TWRSYNQEATDHSELY--WTAPELLRLRESPCSGTPQGDVYSFAILLRDLIHQQAHGPFED 767

  Fly  1184 -MACSSNLYSRSRE----------------------MSQELANEEALLRYIIDSI---------- 1215
             .|....:.||.::                      :.:|..:|...||.|..||
Mouse   768 LEAAPEEIISRIKDPRAPVPLRPSLLEDKGDGRIVALVRECWDESPELRPIFPSIKKTLREASPR 832

  Fly  1216 ----FLFAFMLALIFHSHQTEATYRLDFIWKLQATEEKEDMEHLQAYNR---KLLENILPVHVAE 1273
                .|.:.|..|..:::..|           :..||:  ...|.|..|   |||..:||..|.|
Mouse   833 GHVSILDSMMGKLETYANHLE-----------EVVEER--TRELVAEKRKVEKLLSTMLPSFVGE 884

  Fly  1274 HFLSREKHLDDLYHEQCDSVCILFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDELLSEER 1338
            ..::.:    .:..|..:||.|.|:.|..|:    :|...:..::.::|||::.:.||..:....
Mouse   885 QLIAGK----SVEPEHFESVTIFFSDIVGFT----KLCSLSSPLQVVKLLNDLYSLFDHTIQSHD 941

  Fly  1339 FRCIEKIKSTGATYMAASGLTANTCDRVNFSHVTAMADYALQLFDKIEEVNMH------SFNNFR 1397
               :.|:::.|..||.||||..    |....|...:|..||.|.    .|..|      .....:
Mouse   942 ---VYKVETIGDAYMVASGLPI----RNGAQHADEIATMALHLL----SVTTHFQIGHMPEERLK 995

  Fly  1398 MRIGINIGPVVAGVIGACKPQYDIWGNAVNVASRMDSTGLVDHIQVTQEMQ-QILEGRGFELTCR 1461
            :|||::.|||||||:|...|:|.::|:.||:||||:|:.|...|.|:|... .:|...|:.|..|
Mouse   996 LRIGLHTGPVVAGVVGITMPRYCLFGDTVNMASRMESSSLPLRIHVSQSTAGALLAAGGYHLQKR 1060

  Fly  1462 GSVDVKGKGSMITYFLKGRR--PIDAKELELAKTEVE 1496
            |::.|||||...|::|||:.  |:...|.    ||.|
Mouse  1061 GTISVKGKGEQTTFWLKGKDGFPVPLPEF----TEEE 1093

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:292831
		CYCc	686..881	CDD:214485	12/65 (18%)
		Guanylate_cyc	722..895	CDD:278633	13/79 (16%)
		DUF1053	<949..1005	CDD:283888	13/65 (20%)
		CYCc	1259..1455	CDD:214485	63/205 (31%)
		Guanylate_cyc	1285..1479	CDD:278633	66/200 (33%)
Gucy2g	NP_001074545.1	PBP1_GC_G-like	47..436	CDD:380595
		PK_GC	555..829	CDD:270894	72/392 (18%)
		CYCc	865..1055	CDD:214485	64/208 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900