DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43373 and Adcy3

DIOPT Version :9

Sequence 1:	NP_001097622.2	Gene:	CG43373 / 39835	FlyBaseID:	FBgn0263131	Length:	1854	Species:	Drosophila melanogaster
Sequence 2:	NP_570135.2	Gene:	Adcy3 / 64508	RGDID:	71009	Length:	1144	Species:	Rattus norvegicus

Alignment Length:	1177	Identity:	399/1177 - (33%)
Similarity:	603/1177 - (51%)	Gaps:	213/1177 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   448 YTVASDDDDDVDGG-------RSAGS-------KHITYTPRVRD--YNQISHAERDEVLNTSSNA 496
            |:|:...|.|...|       |::||       ..:|:.|...:  |......:|.|.|
  Rat    20 YSVSLPSDPDRGVGRTHEISVRNSGSCLCLPRFMRLTFVPESLENLYQTYFKRQRHETL------ 78

  Fly   497 GVATDNSDPPLGYGQLIPLILMQVDESVLVFLIVMLICGIVYA--------------------FL 541
                                |:.|..:.|....|:::|.:|::                    |:
  Rat    79 --------------------LVLVVFAALFDCYVVVMCAVVFSSDKLAPLMVAGVGLVLDIILFV 123

  Fly   542 LC-------ILSKPAMNEIFLVLVSYVILGTFLAIEVAVSYAMQPSKSFNGSACCIVLIYMTYTM 599
            ||       .:|:..:..:..:|::..|. ::|.:..:.::|...:..:..     ..::..:..
  Rat   124 LCKKGLLPDRVSRKVVPYLLWLLITAQIF-SYLGLNFSRAHAASDTVGWQA-----FFVFSFFIT 182

  Fly   600 LPLRLREALIGGILLSVVHLYTCLRLNA-----MQDEAVEMIHWEELLCTLVALLLANLTGVYTH 659
            |||.|...:|..::..|||   .|.|..     .|||...|....|:|..:...|.|.:.|:.::
  Rat   183 LPLSLSPIVIISVVSCVVH---TLVLGVTVAQQQQDELEGMQLLREILANVFLYLCAIIVGIMSY 244

  Fly   660 WPKEKAQRKAFIETRQCIEARLRTQRENQQQERLLLSVLPRHVAMEMKDDI---AGQPRDTQFHK 721
            :..::..||||:|.||.:|.::..:.::||||.|:||:||:|||.||..|:   ..|....||:.
  Rat   245 YMADRKHRKAFLEARQSLEVKMNLEEQSQQQENLMLSILPKHVADEMLKDMKKDESQKDQQQFNT 309

  Fly   722 IYIQRHENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVS 786
            :|:.||||||||||||.|||.||..|:|:|||:||||||||||:|||::|.||||:|||||||:.
  Rat   310 MYMYRHENVSILFADIVGFTQLSSACSAQELVKLLNELFARFDKLAAKYHQLRIKILGDCYYCIC 374

  Fly   787 GLPEPRPDHAHCAVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCGVLGLVKWQFDVWSNDV 851
            |||:.|.|||.|::.|||.|::||:.|||.....|:||||:|||.|..||||..:||:||||.||
  Rat   375 GLPDYREDHAVCSILMGLAMVEAISYVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQYDVWSTDV 439

  Fly   852 TLANHMESGGIPGRVHITKETLKCLDGDYEVEVGKGNERNSYLKDHQIETYLIVPGDIYRPHKKS 916
            |:||.||:|||||||||::.|:.||.|:::||.|.|..|..||.:..||||||:..   :|..|.
  Rat   440 TVANKMEAGGIPGRVHISQSTMDCLKGEFDVEPGDGGSRCDYLDEKGIETYLIIAS---KPEVKK 501

  Fly   917 RNRLQVNGN-------ISKELRMMGHGTAQKHTSKFGFGDSSESAKDPEDE-------------- 960
            ..:..:||:       .||........|.:.:.|....|.:||.|::.|.:
  Rat   502 TAQNGLNGSALPNGAPASKPSSPALIETKEPNGSAHASGSTSEEAEEQEAQADNPSFPNPRRRLR 566

  Fly   961 VNEYLMRAIDARSIDH----------LRAEHCQ--------SLLLCFKDNVLERKYASEPDRMLC 1007
            :.:...|.:||...:|          |..|..|        .|.:.|.|..:|.:|:.|.::...
  Rat   567 LQDLADRVVDASEDEHELNQLLNEALLERESAQVVKKRNTFLLTMRFMDPEMETRYSVEKEKQSG 631

  Fly  1008 VYFYCSLLVLLGTSIMRLVV---FQSSLLTLALSTGALLLLGFLVFLVACHKINF---QLPSDIK 1066
            ..|.||.:||..|:::.:::   ..::.:|..:  |.:|||    .|..|.....   ..|..:.
  Rat   632 AAFSCSCVVLFCTAMVEILIDPWLMTNYVTFVV--GEVLLL----ILTICSMAAIFPRAFPKKLV 690

  Fly  1067 RFSLRIHSNRRISQLFAFASVALIVLTTLLAMFQESGRQMELLQRRRFWLDVNGSISLNDTELNT 1131
            .||..|...|.....:|..::.::|:..::.|       :..||......:|...|.|:...:..
  Rat   691 AFSSWIDRTRWARNTWAMLAIFILVMANVVDM-------LSCLQYYMGPYNVTTGIELDGGCMEN 748

  Fly  1132 KMYDAEEPDCDFYLAYNTFLLLTLLSMMSCATYQVLRI--LLKLLLLLLASGSYMACSSNLYS-- 1192
            ..|            ||...:|:|:     ||..::::  ::||.|:||.:|:..|.  |||:
  Rat   749 PKY------------YNYVAVLSLI-----ATIMLVQVSHMVKLTLMLLVTGAVTAI--NLYAWC 794

  Fly  1193 ---------RSREMSQELANEEAL-------------------LRYIIDSIFLFAFMLALIFHSH 1229
                     |.:|....:...|.:                   .:|.: ::.:|..||:..:.|.
  Rat   795 PVFDEYDHKRFQEKDSPMVALEKMQVLSTPGLNGTDSRLPLVPSKYSM-TVMMFVMMLSFYYFSR 858

  Fly  1230 QTEATYRLDFIWKLQATEEKEDMEHLQAYNRKLLENILPVHVAEHFLSREKHLDDLYHEQCDSVC 1294
            ..|...|..|:||::..::||.:..::.:|..|:.|:||.|||.|||..:|..::||.:..|.:.
  Rat   859 HVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYSQSYDEIG 923

  Fly  1295 ILFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDELLSEERFRCIEKIKSTGATYMAASGLT 1359
            ::|||:|||::||.|...||.|:||||.|||||:|||.||...:||.|.|||:.|:|||||||:|
  Rat   924 VMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKTIGSTYMAASGVT 988

  Fly  1360 --ANT-----------CDRVNFSHVTAMADYALQLFDKIEEVNMHSFNNFRMRIGINIGPVVAGV 1411
              .||           .|:..:.|:..:||:||.:.|.:..:|..|||||.:|||:|.|.|:|||
  Rat   989 PDVNTNGFTSSSKEEKSDKERWQHLADLADFALAMKDTLTNINNQSFNNFMLRIGMNKGGVLAGV 1053

  Fly  1412 IGACKPQYDIWGNAVNVASRMDSTGLVDHIQVTQEMQQILEGRGFELTCRGSVDVKGKGSMITYF 1476
            |||.||.||||||.|||||||:|||::.:|||.:|.|.||...||....||.:.|||||.::|:|
  Rat  1054 IGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVILREYGFRFVRRGPIFVKGKGELLTFF 1118

  Fly  1477 LKGR-RP 1482
            |||| ||
  Rat  1119 LKGRDRP 1125

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:292831	56/231 (24%)
		CYCc	686..881	CDD:214485	122/197 (62%)
		Guanylate_cyc	722..895	CDD:278633	110/172 (64%)
		DUF1053	<949..1005	CDD:283888	17/87 (20%)
		CYCc	1259..1455	CDD:214485	108/208 (52%)
		Guanylate_cyc	1285..1479	CDD:278633	108/206 (52%)
Adcy3	NP_570135.2	AC_N	<44..303	CDD:318454	65/293 (22%)
		Guanylate_cyc	310..494	CDD:306677	117/183 (64%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	504..563		11/58 (19%)
		Guanylate_cyc	914..1121	CDD:306677	108/206 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.710