DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG43373 and Phlpp1

DIOPT Version :9

Sequence 1:NP_001097622.2 Gene:CG43373 / 39835 FlyBaseID:FBgn0263131 Length:1854 Species:Drosophila melanogaster
Sequence 2:XP_038946976.1 Gene:Phlpp1 / 59265 RGDID:621308 Length:1718 Species:Rattus norvegicus


Alignment Length:2109 Identity:366/2109 - (17%)
Similarity:625/2109 - (29%) Gaps:810/2109 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly    51 AAGGPGGSGTSSLASSKEESKHRKFFSRSASLRQAGSGGGGVGVGGVVGGSGSHQASMEL---HV 112
            ||...||....|:.|:                 .|.|||.        ||:...:|..|.   .:
  Rat    25 AAAAEGGRSPDSVLSA-----------------AAPSGGN--------GGAAREEAPCEAPPGPL 64

  Fly   113 PGQE-GRGTSSGAGSPQTQTQPSTPKKSNWEVIEHFNTSAKGGKAVVSSSLIAAGITRCNIDESM 176
            ||:. |.|.....|.||.....:.|.           |:|.||   .:|.|:..|..:.|:..:.
  Rat    65 PGRAGGTGRRRRRGVPQPAAGGAAPV-----------TAAGGG---ANSLLLRRGRLKRNLSAAA 115

  Fly   177 DSTNSSSTCHSPMIYQRDETQLLQPGDASNLEANNPMSSGGGGGTANGPVSPSISFWFRLNRIIL 241
            .|::|.|:.                            ||..||..|:...|.|            
  Rat   116 SSSSSPSSA----------------------------SSAAGGLPASCSASAS------------ 140

  Fly   242 RLCSTHQFKNLQVEMLYQ--RYFLRMNQSN----------------TTHILALLLALILALSCTL 288
             ||:    ::|..:.|.|  |..|::..|:                ..|:.:..|..:|   |||
  Rat   141 -LCT----RSLDRKTLLQKHRQLLQLQPSDRDWVRHQLQRGCVHVFDRHMASSYLRPVL---CTL 197

  Fly   289 ------LVFTTLQLRRSTSLLLEI-------------------SEIGLD-----ANATVGNLTTA 323
                  :....|||......::::                   :|:|.|     :::|||.:...
  Rat   198 DTTAAEVAARLLQLGHKGGGVVKVLGHGPPPAAAPAASDQTPATELGRDVEPPPSSSTVGAVRGP 262

  Fly   324 TMKPPTLASSDQMTRGSSIPLLALASNGSWAGNGAVGGELKSAHNHNIADFEADHNGQLVWRRQK 388
            ...||           :.:||    ..|:|                                   
  Rat   263 ARAPP-----------ADLPL----PGGAW----------------------------------- 277

  Fly   389 RKHYRRLHKHRYKHKSHQQHRTRYRMREKRSLQDAG---LVKGGGIQTQLIVDTATDDDA-DVYT 449
                                 ||...|...:..|:.   |..||..........|:|.:: .:..
  Rat   278 ---------------------TRCAPRVNPAPSDSSPGELFAGGPCSPSRAPRPASDTESFSLSP 321

  Fly   450 VASDDDDDVD-----GGRSAGSKHITYTPRVRDYNQISHAERDEVLNTSSNAGVATDNSDP---P 506
            .|....|.:|     ||.|:.|:.:...|                      |.|.|..|.|   |
  Rat   322 SAESVSDRLDPYSSGGGSSSSSEELEADP----------------------ATVLTGPSGPPHHP 364

  Fly   507 LGYGQLIPLILMQVDESVLVFLIVMLICGIVYAFLLCILSKPAMNEIFLVLVSYVILGTFLAIEV 571
            :...|..|                               ..|..:.:........:.||.|    
  Rat   365 VRSSQPRP-------------------------------PSPKTSALLQPKAPTGVDGTGL---- 394

  Fly   572 AVSYAMQPSKSFNGSACCIVLIYMTYTMLPLRLREAL----IGGILLSVVHLYTCLRLNA----- 627
            .|.......|:...:|..:.|      ..|.|:||.:    ....|...:|..|..||.|     
  Rat   395 VVGEGPGDDKAVAAAAPGVPL------WTPGRIRETVQKTSSPPSLYVQLHGETTRRLEADEKPL 453

  Fly   628 -MQDEAVEMIHWEELLCTLVALLLANLTGVYTHWPKEKAQRKAFIETRQCIEARLRTQRENQQQE 691
             :|::.:..:.:.||                  |                     |.|.|....|
  Rat   454 QIQNDYLFQLGFGEL------------------W---------------------RVQEEGMDSE 479

  Fly   692 RLLLSVLPRHVAMEMKDDIAGQPRDT------QFHKIY----------IQRHENVSILFADICG- 739
               :..|.|.        .||:|..|      |...:|          :.|.....::   :|| 
  Rat   480 ---IGCLIRF--------YAGKPHSTGSSERIQLSGMYNVRKGKMQLPVNRWTRRQVI---LCGT 530

  Fly   740 ---FTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLG---DCYY-C------------- 784
               .:|:.|..:.:  :.:|..:..:.:.:....|||.....|   ..|| |             
  Rat   531 CLIVSSVKDSSSGK--MHVLPLIGGKVEEVKKHQHCLAFSSSGPQSQTYYICFDTFTEYLRWLRQ 593

  Fly   785 VSGLPEPR---PDHAHCAVE-------MGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCGVLGL 839
            ||.:...|   .|.:.|::|       ...|:.. :.|.:..:..|.::.          ...||
  Rat   594 VSKVASQRISSVDLSCCSLEHLPANLFYSQDLTH-LNLKQNFLRQNPSLP----------AARGL 647

  Fly   840 VKWQFDVWSNDVTLA-NHMESGGIPGRV----HITKETLKCLDGDYEVEVGKGNERNSYLKDHQI 899
            .:.|.......:.|: ||:  |..|..|    .:.:..:.| :...||....|..:|       :
  Rat   648 GELQRFTKLKSLNLSNNHL--GAFPSAVCSIPTLAELNVSC-NALREVPAAVGAMQN-------L 702

  Fly   900 ETYLI-------VPGDIYRPHKKSRNRLQVN---------------------GNISKELRM---- 932
            :|:|:       :|.::...|:.|...|..|                     ||..:.||:    
  Rat   703 QTFLLDGNFLQSLPAELENMHQLSYLGLSFNEFTDIPEVLEKLTAVDKLCMAGNCMETLRLQALR 767

  Fly   933 -MGHGTAQKHTSKFGFGDSSESAKDPED--------EVNEYLMRAIDARSIDHLRAEHCQ----- 983
             |.|   .||.. .......:...|..|        ::.:..:..:||...:::...||:     
  Rat   768 RMPH---IKHVD-LRLNILRKLITDEVDFLQHVTQLDLRDNKLGDLDAMIFNNIEVLHCERNQLV 828

  Fly   984 SLLLCFKDNVLERKYASEPDRM-LCVYFYCSLLVLLGT------SIMRLVVFQSSLLTLALSTGA 1041
            :|.:|  ...|:..|||..:.: |.||...:.|..:..      |:...|.....|..|.:....
  Rat   829 TLNIC--GYFLKALYASSNELVQLDVYPVPNYLSYMDVSRNCLESVPEWVCESRKLEVLDIGHNQ 891

  Fly  1042 LLLLGFLVF-------LVACHKINFQLPSDIKRFSLRI----HSNRRISQLFAFASVALIVLTTL 1095
            :..|...:|       |:|.|....:||..::|.|:.:    |:.             :|.|...
  Rat   892 ICELPARLFCNSSLRKLLAGHNRLARLPERLERTSVEVLDVQHNQ-------------IIELPPN 943

  Fly  1096 LAMFQESGRQMELLQRRRFWLDVNGSISLNDTELNTKMYDAEEPDC---DFYLAYNTFLLLTLLS 1157
            |.|..:|.|.:              :.|.|..|.......:||...   :.||..|:.       
  Rat   944 LLMKADSLRFL--------------NASANKLETLPPATLSEETSSILQELYLTNNSL------- 987

  Fly  1158 MMSCATYQVLRILL---KLLLLLLASGSYMACSSNLYSRSREMSQELANEEALLRYIIDSIFLFA 1219
                 |.:.:.:|.   :|.:|.:|.....:..::..::..|: :|:......|:.|..:|....
  Rat   988 -----TDKCVPLLTGHPRLKILHMAYNRLQSFPASKMAKLEEL-EEIDISGNKLKAIPTTIMNCR 1046

  Fly  1220 FMLALIFHSHQTEATYRLDFIWKLQATEEKEDMEHLQAYNRKLLENILPVHVAEHFLSREKHLDD 1284
            .|..:|.||:..|....:..:.::::||                        ....|||...|..
  Rat  1047 RMHTVIAHSNCIEVFPEVMQLPEVKSTE------------------------GNGSLSRSSFLFP 1087

  Fly  1285 LYHEQCDSVCILFASI-------PNFSEFYVELEGNNE---GVECLRLLNEIIADFDELLSEERF 1339
            |:|:..|..|...:.|       |...|  ::|.||..   ..:.|.|||.|             
  Rat  1088 LFHQCVDLSCNELSEITLPENLPPKLQE--LDLTGNPRLALDHKSLELLNNI------------- 1137

  Fly  1340 RCIEKI------KSTGAT------YMAASGLTANTC----------------------DR---VN 1367
            ||. ||      .::||.      |..|||:....|                      ||   |.
  Rat  1138 RCF-KIDQPSAGDASGAPAVWSHGYTEASGVKNKLCVAALSVNNFRDNREALYGVFDGDRNVEVP 1201

  Fly  1368 FSHVTAMADYALQLFDKI---EEVNMHSFNNFRMRIGINIGPVVAGVIGACKPQYDIWGNAVNVA 1429
            :.....|:|...:...|.   ||..:::|...:.::|      .||        ..:.|.||...
  Rat  1202 YLLQCTMSDILAEELQKTKNEEEYMVNTFIVMQRKLG------TAG--------QKLGGAAVLCH 1252

  Fly  1430 SRMDSTGLVDHIQVTQEMQQILEGRGFELTCRGSVDVKGKGSMITYFLKGRRPIDAKELELAKTE 1494
            .|.|...|               |..|.||   |.:|   |...|...:..:|:...        
  Rat  1253 IRHDPVDL---------------GGSFTLT---SANV---GKCQTVLCRNGKPLSLS-------- 1288

  Fly  1495 VEPPKTLTLAKEPEKLDSGTATEKQREQVKEQGSTEQEDDLLPSPDIDMNSNMQNLTAQRR---- 1555
                ::.|:           :.|::|:::|:..:...||           ..:..:|...|    
  Rat  1289 ----RSYTM-----------SCEEERKRIKQHKAIITED-----------GKVNGVTESTRILGY 1327

  Fly  1556 ----KSLCRQHNISSSFGTT-----VSSSTGITPSISNSSSVVTIGALPAILRGGNPLSNANPN- 1610
                .|:..:.::.|...|.     :..|.|:..|:|...:|..:..:|..|.....|.....: 
  Rat  1328 TFLHPSVVPRPHVQSVLLTPQDEFFILGSKGLWDSLSIEEAVEAVRNVPDALAAAKKLCTLAQSY 1392

  Fly  1611 ---------------ATDS--CSECG-GASKSLATPTAPPRTLVADLKDEIARDEKIGLKDSIEN 1657
                           ..||  |.|.. |.|....:|...|.::...:||.  ..:.:|:..|...
  Rat  1393 GCHDSISAVVVQLSVTEDSFCCCELSVGGSMPPPSPGIFPPSVSMVIKDR--PSDGLGVPSSSSG 1455

  Fly  1658 LEILLKNNISLSDLSNKQQQNLRGETSSSTTTTLRKRDTIVSFNVTETVTTTAAPFTSSSGSSNS 1722
            :...:.:.:|.|::|::                               |.:||:....|...|.|
  Rat  1456 MASEISSELSTSEMSSE-------------------------------VGSTASDEPPSGALSES 1489

  Fly  1723 S----SQQKKRRSVTTIAASF----TTSTTTRLLSNESQSSTQTAP--GTLESGG---------- 1767
            |    |:|:.......::.||    :::|.:...|:....|....|  |...:|.          
  Rat  1490 SPAYPSEQRCMLHPVCLSNSFQRQLSSATFSSAFSDNGLDSDDEEPIEGVFSNGSRVEVEVDIHC 1554

  Fly  1768 -------------SVPGQSSTE----NSSQDWQPRTASLEPNRSPIKTSQSMSPIGQLTTEVFVL 1815
                         .||.::|.|    ::::|        |...|......::..||:......|.
  Rat  1555 SRAKEKERQQHLLQVPAEASDEGIVISANED--------ESGLSKKTDISAVGTIGRRRANGSVA 1611

  Fly  1816 PNSRSMVLISSTNGSVSALATGGGGASSP 1844
            |..||..:|.....  :.|...||..::|
  Rat  1612 PQERSHNVIEVATD--APLRKPGGYFAAP 1638

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG43373NP_001097622.2 AC_N <523..720 CDD:292831 33/212 (16%)
CYCc 686..881 CDD:214485 42/246 (17%)
Guanylate_cyc 722..895 CDD:278633 37/218 (17%)
DUF1053 <949..1005 CDD:283888 12/68 (18%)
CYCc 1259..1455 CDD:214485 49/245 (20%)
Guanylate_cyc 1285..1479 CDD:278633 52/243 (21%)
Phlpp1XP_038946976.1 Ubiquitin_like_fold 176..>224 CDD:421700 9/50 (18%)
PHA03247 <237..443 CDD:223021 51/339 (15%)
RA_PHLPP1 <424..491 CDD:340760 18/116 (16%)
PH_PHLPP-like 498..594 CDD:270131 15/100 (15%)
PLN00113 602..>1109 CDD:215061 105/597 (18%)
leucine-rich repeat 604..624 CDD:275380 3/19 (16%)
leucine-rich repeat 625..655 CDD:275380 5/40 (13%)
leucine-rich repeat 679..701 CDD:275380 4/22 (18%)
leucine-rich repeat 702..724 CDD:275380 3/21 (14%)
leucine-rich repeat 725..771 CDD:275380 8/45 (18%)
leucine-rich repeat 772..795 CDD:275380 4/23 (17%)
leucine-rich repeat 796..816 CDD:275380 2/19 (11%)
leucine-rich repeat 817..858 CDD:275380 11/42 (26%)
leucine-rich repeat 859..881 CDD:275380 3/21 (14%)
leucine-rich repeat 882..904 CDD:275380 4/21 (19%)
leucine-rich repeat 905..926 CDD:275380 6/20 (30%)
leucine-rich repeat 927..950 CDD:275380 5/35 (14%)
leucine-rich repeat 951..974 CDD:275380 6/36 (17%)
leucine-rich repeat 977..1000 CDD:275380 5/34 (15%)
leucine-rich repeat 1001..1024 CDD:275380 3/22 (14%)
leucine-rich repeat 1067..1112 CDD:275380 11/68 (16%)
PP2Cc 1151..1403 CDD:214625 53/320 (17%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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