DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43373 and CG34357

DIOPT Version :9

Sequence 1:	NP_001097622.2	Gene:	CG43373 / 39835	FlyBaseID:	FBgn0263131	Length:	1854	Species:	Drosophila melanogaster
Sequence 2:	NP_001356914.1	Gene:	CG34357 / 5740349	FlyBaseID:	FBgn0085386	Length:	1689	Species:	Drosophila melanogaster

Alignment Length:	1848	Identity:	370/1848 - (20%)
Similarity:	609/1848 - (32%)	Gaps:	598/1848 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   307 SEIGLDANATVGNLTTATMKPPTLASSDQMTRGSSIPLLA----LASNGSWAGNGAVGGELKSAH 367
            ||..|.::..|  |..|........|:|..||  |:|..|    |.|...|    ....:.||..
  Fly    58 SEKPLHSDVLV--LRAAKPSRAIATSADAATR--SVPASAAETTLGSKSIW----PTAIQTKSPR 114

  Fly   368 NHNIADFEADHNGQL----VWRRQKRKHYRRLHKHRYKHKSHQQHRTRYRMREKR-------SLQ 421
            |...|   ..|..|:    :.::..::..:|::..:.|.:..||.:.:.:.:.:|       ||.
  Fly   115 NAREA---GRHKRQMQKPAIQQQPLQQQQQRINPPQQKRQQQQQQQQQVQHQAQRVGVLIPPSLH 176

  Fly   422 -DAGLVKGGGIQT-----QLIVDTATDD---DADV-----------YT-----------VASDDD 455
             |...|: .|.|.     ||.:...|.|   |.|:           ||           |||..|
  Fly   177 VDLTHVQ-QGFQNFLDFFQLHLFNVTVDFLRDVDLSGFIKLLELPKYTSVIKTLNAGIMVASHVD 240

  Fly   456 DDVDGGRSAGS------KHITYTPRVRDYNQISH---------AERDEVLNTSSNAGVATDN--S 503
            .|.:.....|:      :|..::.:.::.::..|         |..:|    |.::|...:|  :
  Fly   241 VDQNSTIYIGTPSQPRQQHRLHSKQEQEPHRHHHEDSKAKQFPAGEEE----SHSSGETEENHWN 301

  Fly   504 DPPLGYG---QLIPLILMQVDESVLVFLIVMLICGIVYAFLLCILSKPAMNEIFLVLVS------ 559
            |..:..|   ||...:.:..:::|:::....:  .|...||      |:...|.|.:.|
  Fly   302 DARIFSGHCHQLAEQLALDFNKTVVLWPCPRM--KISSNFL------PSFEAISLAVQSISTKLN 358

  Fly   560 ------YV-----ILGTFLAIEVAVSYAMQPSKSFN--------GSACCIVLIYMTYTMLPLRLR 605
                  |:     .||..:|..:.|.|.::..::..        |.|..|.        .||...
  Fly   359 WSQVDIYIGDDNWGLGLAIAANLHVPYRIEIGRTIRDLHSQDKPGKAIIIT--------APLNDA 415

  Fly   606 EALIGGILLSVVHL-YTCLRLNAMQDEAVEMIHWEELLCTLVALLLANLTGVYTHWPK-EKAQRK 668
            ..:   :|||.:.| :|.......|.......|.:.||..:.|..|....|.|.:..: ..:|..
  Fly   416 STI---LLLSTIELDWTEQARKDGQGSRPGRQHTKILLIDMAASSLDTQHGFYKYLSRMGGSQSD 477

  Fly   669 AFIET----RQCIEARLRTQRENQQQERLLLSVLPRHVAME---------MKDDIAGQPRDTQFH 720
            ||...    .:.:.:.|........:.||.|:.......|:         .||......|:...|
  Fly   478 AFARNTGSPAEVVSSNLLVLTLLNDRHRLFLNAAGLMATMQNFRAPLNGNYKDPPPSGHRNASLH 542

  Fly   721 KIYIQRHENVSILFADICGFTSLSDQCTAE----------ELVRLLNELFARFDRLAAEHHCLRI 775
            |:|..|  |:..|:..|...|:.||  |:|          ::||         |...|.:....:
  Fly   543 KLYPYR--NLLPLYDTIVTTTTQSD--TSETSPQFDFVVLDIVR---------DAPVATYKWRPL 594

  Fly   776 KLL---------------GDCYYCVSGLPEPRPDH-------------AHCAVEMGLDMIDAIAL 812
            .:|               |..|  :|....|..|.             |.|.....:.:...:.:
  Fly   595 LILESDPGSRGGGSVVEGGGSY--ISHSIHPGYDEWLLVSSVLLWQCGAICWTIAAICVCLLVIM 657

  Fly   813 VREVMAVNVNMRVGIHTGRVHCG----VLGLVKWQFDVWSNDVTLANHMESGGIPGRVHITKETL 873
            :..::|..:.||......|:..|    ||....:.|.|.|..|       ..||...:....:.|
  Fly   658 IAGIVAGGIAMRNYFLRKRLSKGPNKIVLSASDFVFPVDSRRV-------DEGIEAMLCCWLQQL 715

  Fly   874 KCLDGDYEVEVGK--------GNERNSYLKDHQIETYLIVPGDIYRPHKKSRNRLQVNGNISKEL 930
            :...|.   ||.|        |:.:|         ...::|| ...|..........||.....
  Fly   716 QEFGGP---EVDKPDLLKGSIGSLKN---------LGFVIPG-AAAPGSAGAITTTANGKSGSS- 766

  Fly   931 RMMGHGTAQKHT-------SKFGFGDSSESAKDPEDEVN-----EYLMRAIDARSIDH-LRAEHC 982
               ..|:..:|.       :::. ||..:.     .|||     |...:|:|...:.| ||.|:.
  Fly   767 ---ATGSLARHNPAHLDMRARYN-GDLVQL-----KEVNINGSAELRTKAMDLLVMAHGLRHENI 822

  Fly   983 QSLLLCFKDNVLERKYASEPDRMLCVYFYCSLLVLLGTSIMRLV----VFQSSLLT------LAL 1037
            ..|:          .:.|:|:|...|:.|||...|....||..:    .|:.||||      ..|
  Fly   823 NPLI----------GWLSDPNRTAMVFDYCSRGSLQDVLIMDEIKLDWSFRLSLLTDLVRGMRYL 877

  Fly  1038 STGALLLLGFL-----------VFLVACHKIN-------------------FQLPSDIKRFSL-- 1070
            .|..|.:.|.|           |..:..:.:|                   :..|..::...|
  Fly   878 HTSPLRVHGALTSRNCVVDARWVLKITDYGLNSFYESQGLPPRTRSAKELLWTAPELLRNMKLHQ 942

  Fly  1071 ------RIHSNRRISQLFAFASVALIVLTTLLAMFQESGRQMELLQRRRFWLDVNGS----ISLN 1125
                  ||....::..:::|..:...|:                         |.|.    :||:
  Fly   943 HHHQHGRIQLGTQLGDVYSFGIIMQEVV-------------------------VRGEPYCMLSLS 982

  Fly  1126 DTELNTKMYD--------------------------AEEPDC--DFYLAYNTFLLLTLLSMMSCA 1162
            ..|:..|:..                          ||:||.  ||...|..|.:|.
  Fly   983 PEEIIVKIKKPPPLIRPSVSKGAAPPEAINIMRQCWAEQPDMRPDFNSVYERFKMLN-------- 1039

  Fly  1163 TYQVLRILLKLLLLLLASGSYMACSSNLYSRSREMSQELANEEALLRYIIDSIFLFAFMLALIFH 1227
                             .|..:.....::....:.|..|   |.|:|
  Fly  1040 -----------------HGRKVNFVDTMFQMLEKYSNNL---EELIR------------------ 1066

  Fly  1228 SHQTEATYRLDFIWKLQATEEKEDMEHLQAYNRKLLENILPVHVAEHFLSREKHLDDLYHEQCDS 1292
                |.|.:||.       |.|:        ..:||..:||..|||. |.....:|.   |:...
  Fly  1067 ----ERTEQLDI-------ERKK--------TEQLLNRMLPSSVAEK-LKMGLAVDP---EEFSD 1108

  Fly  1293 VCILFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDELLSEERFRCIEKIKSTGATYMAASG 1357
            |.|.|:.|..|:    .:..:...|:.:.|||::...||..::...   :.|:::.|..||..||
  Fly  1109 VTIYFSDIVGFT----TIAAHCSPVQVVDLLNDLYTIFDATINAYN---VYKVETIGDAYMVVSG 1166

  Fly  1358 LTANTCDRVNFSHVTAMADYALQLFDKIEEVNMHSFNN--FRMRIGINIGPVVAGVIGACKPQYD 1420
            |.....|     |...:|..||.|..:....|:.....  .::|||::.||..|||:|...|:|.
  Fly  1167 LPVKIPD-----HAEQIATMALDLLHQSGRFNVKHLPGVPLQLRIGLHTGPCCAGVVGLTMPRYC 1226

  Fly  1421 IWGNAVNVASRMDSTGLVDHIQVTQEMQQILEGR-GFELTCRGSVDVKGKGSMITYFLKGRRPID 1484
            ::|:.||.||||:|||....|.::||.:..|:.| |:.:..||.:|:||||.|.|::|.|::..|
  Fly  1227 LFGDTVNTASRMESTGSSWRIHMSQETRDRLDARGGYAIEPRGLIDIKGKGMMNTFWLLGKKGFD 1291

  Fly  1485 AKELELAKTEVEPP--------------KTLTLAKEPEKLDSGTATEKQREQVKEQGSTEQEDDL 1535
                   |....||              .::||..:..|..:.|.....:.......|.|.:.::
  Fly  1292 -------KPLPAPPPIGESHGLDESLIRNSITLKAQANKSRTSTNPSSSQSSSLAGESVEVKVEI 1349

  Fly  1536 LPSPDIDMNS-----NMQNLTAQRRKSLCRQHNISSSF-GTTVSSSTG--------ITPS----- 1581
            .|..:.|:.|     |..:|.:....::.....:...| |.|..|||.        :||.
  Fly  1350 TPPTNADLASGTNLPNSYSLDSNSTNTISPNATLCPEFPGKTTPSSTSPQSRKLSELTPENLLNP 1414

  Fly  1582 ------------------------------------ISNSSSVVT--------IGALPAILRGGN 1602
                                                :|.|.|.:|        .|::.....||.
  Fly  1415 NSFNRLPSSTGGSSSRLYKKIEEMMDLSSPYNHYKCLSPSESNLTQFYDGKYLYGSVAGGAGGGQ 1479

  Fly  1603 PLSNANPNATDSCSECGGASKSLATPTAPPRTL----VADLKDEIARDEKI-------------- 1649
            ....|..:...|.|.|||.:....:.....|.|    ..|..|:.|:.|:.
  Fly  1480 AGGGACASIALSGSGCGGGASRFDSKPGSSRLLRRQFSLDRDDQQAKGEQQHHQHSLQANTYSGL 1544

  Fly  1650 ------GLKDSIENLEILLKNNISLS---DLSNKQQQNLRGETSSSTTTTLRKRDTIVSFNVTET 1705
                  |:|.|:  |:|.|.::.:.|   .|:...:||     |:|.|..|.|.:.|
  Fly  1545 VGGCGGGVKSSM--LDIPLLHDTTRSPKGTLTRSHKQN-----SASITQDLEKIEEI-------- 1594

  Fly  1706 VTTTAAPFTSSSGSSNSSSQQKKRRS-VTTIAASF--------------TTSTTTRLLSN---ES 1752
                  |.:.:|...:||......|| .:|:.|..              |:...:|.|:.   .:
  Fly  1595 ------PLSPASSQHHSSLDSNLNRSPPSTLEAQSPPLPPMSPPQLSAPTSPAPSRTLNGIYAHN 1653

  Fly  1753 QSSTQTAPGTLESGGSVPGQSSTENSSQ 1780
            .:||.:......:.|:.||...|.|:.|
  Fly  1654 SNSTSSHGAANNNNGTHPGPELTLNAEQ 1681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:292831	43/236 (18%)
		CYCc	686..881	CDD:214485	46/245 (19%)
		Guanylate_cyc	722..895	CDD:278633	42/222 (19%)
		DUF1053	<949..1005	CDD:283888	14/61 (23%)
		CYCc	1259..1455	CDD:214485	61/198 (31%)
		Guanylate_cyc	1285..1479	CDD:278633	63/196 (32%)
CG34357	NP_001356914.1	PKc_like	763..1041	CDD:354810	58/347 (17%)
CG34357	NP_001356914.1	CYCc	1074..1266	CDD:214485	64/222 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810