Protein Alignment CG43373 and adcy3a

DIOPT Version :10

• Sequence 1: NP_001097622.2
• Gene: CG43373 / 39835
• FlyBaseID: FBgn0263131
• Length: 1854
• Species: Drosophila melanogaster
• Sequence 2: XP_009290286.2
• Gene: adcy3a / 571825
• ZFINID: ZDB-GENE-111027-6
• Length: 1119
• Species: Danio rerio
• Alignment Length: 1063
• Identity: 392/1063 - (36%)
• Similarity: 591/1063 - (55%)
• Gaps: 139/1063 - (13%)

  Fly   519 QVDESVLVFLI--------VMLICGIVYA--------------------FLLC---ILSKPAMNE 552
            |..|::||.::        ::::|.::|.                    :|||   :|.    :.
Zfish    73 QRHETLLVLVVFAALFDCYIIVMCTVLYTADKLASVAVASVGLAADVLLYLLCRYGLLP----DR 133

  Fly   553 IFLVLVSY---VILGTFLAIEVAVSYAM--QPSKSFNGSACCIVLIYMTYTMLPLRLRE-ALIGG 611
            :...||.|   |::...:...:.:::|.  |||.:....|......::|   |||||.. .||..
Zfish   134 VTRRLVPYALWVLIAAQIFCYLGLNFARFHQPSDTVGWQAFFSFSFFLT---LPLRLTPIVLITS 195

  Fly   612 ILLSVVHLYTCLRLNAMQDEAVE-MIHWEELLCTLVALLLANLTGVYTHWPKEKAQRKAFIETRQ 675
            :...|..|...:.:...|.|.:: .....:||..:|..:.|...||.:::..::..||||:|.||
Zfish   196 VSCGVHTLVLGVTIAQQQQEDIQGAALGRQLLANMVIYVCAITVGVMSYYMADRKHRKAFLEARQ 260

  Fly   676 CIEARLRTQRENQQQERLLLSVLPRHVAMEMKDDI---AGQPRDTQFHKIYIQRHENVSILFADI 737
            .:|.:|..:.::|||||||||:||:|:|.||..|:   |.|....||:.:|:.||||||||||||
Zfish   261 SLEVKLNLEEQSQQQERLLLSILPKHIADEMLQDMKKEASQKEMQQFNTMYMYRHENVSILFADI 325

  Fly   738 CGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEPRPDHAHCAVEM 802
            .|||.||..|:|:|||:||||||||||:|||::|.||||:|||||||:.|||:.|.|||.|::.|
Zfish   326 VGFTQLSSSCSAQELVKLLNELFARFDKLAAKYHQLRIKILGDCYYCICGLPDYREDHAACSIMM 390

  Fly   803 GLDMIDAIALVREVMAVNVNMRVGIHTGRVHCGVLGLVKWQFDVWSNDVTLANHMESGGIPGRVH 867
            ||.|::||:.|||....:|:||||:|:|.|..||||..:||:||||.|||:||.||:||||||||
Zfish   391 GLAMVEAISYVREKTQTDVDMRVGVHSGMVLGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGRVH 455

  Fly   868 ITKETLKCLDGDYEVEVGKGNERNSYLKDHQIETYLIV--PGDIYRPHKKSRNRLQV-----NGN 925
            |::.||:||.|:::||.|.|.:|..|||:..|||||:|  .|.:   .|...|.:::     |||
Zfish   456 ISQNTLECLHGEFDVEPGNGGDRCEYLKERGIETYLVVLPKGPV---GKNGINGVKLSVTSSNGN 517

  Fly   926 ISKELRMMGHGTAQKHTS------------------------KFGFGDSSE---SAKDPEDEVNE 963
             |..|..........||:                        :....|.:|   .|::.|.|:|:
Zfish   518 -SPLLINTTECNGSVHTACTTPEDPEELDTRVVNPSFPNPRRRLRLRDLAERVIDAQENEQELNK 581

  Fly   964 YLMRA-IDARSIDHLRAEHCQSLLLCFKDNVLERKYASEPDRMLCVYFYCSLLVLLGTSIMRLVV 1027
            .|..| ::..::..|:.::...|.|.|.|..||.:::.|.::.....|.||.:|||.|::|..::
Zfish   582 LLNEALLERETVQALKGKYTNRLSLRFTDPELETRFSVEKEKQSGAAFSCSCVVLLFTAVMEALI 646

  Fly  1028 ---FQSSLLTLALSTGALLLLGFLVFLVACHKINFQLPSDIKRFSLRIHSNRRISQLFAFASVAL 1089
               ..::.:|||:....||:|..........::   .|..:..||..|...|.....:|.|::.:
Zfish   647 DPWLVANYVTLAVGEVLLLILTICSLAAIFPRV---FPKRLVSFSTWIDHTRWARNTWAMAAIFI 708

  Fly  1090 IVLTTLLAMFQESGRQMELLQRRRFWLDVNGSISLNDTELNTKMYD-AEEPDCDFYLAYNTFLLL 1153
            :.|..::.|......|...::            |.....:.|.:.. ||.|....::|....:..
Zfish   709 VTLADIVDMLSCRAPQTSTVE------------STAVPPVVTAIRGCAENPKYYSFIAVLALIAT 761

  Fly  1154 TLLSMMSCATYQVLRILLKLLLLLLASGSYMACSSNLYSRSREMSQELANEEALLRYIID----- 1213
            |:|..:|    .::::.| :||:.:|:|:.     |:||.|:..  :|.:......|.::
Zfish   762 TMLVQVS----HMVKLTL-MLLITVATGAV-----NIYSWSQTF--DLYDLTRFKEYRVNLVPSK 814

  Fly  1214 ---SIFLFAFMLALIFHSHQTEATYRLDFIWKLQATEEKEDMEHLQAYNRKLLENILPVHVAEHF 1275
               |:.:|..|::..:.|...|...|..|:||::..|:||.:..::.:|..|:.|:||.|||.||
Zfish   815 YTMSVMIFIMMVSFYYFSRHVEKLARTLFLWKIEVHEQKEKVYEMRRWNEALVTNMLPEHVARHF 879

  Fly  1276 LSREKHLDDLYHEQCDSVCILFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDELLSEERFR 1340
            |..:|..::||.:..|.:.::||||||||:||.|...||.|:||||.|||||:|||.||.|.:||
Zfish   880 LGSKKRDEELYSQSYDEIGVMFASIPNFSDFYTEESINNGGIECLRFLNEIISDFDSLLDEPQFR 944

  Fly  1341 CIEKIKSTGATYMAASGLTA--NT----C-------DRVNFSHVTAMADYALQLFDKIEEVNMHS 1392
            ||.|||:.|:|||||||:|:  ||    |       ||..:.|:..:||:||.:...:..:|..|
Zfish   945 CITKIKTIGSTYMAASGVTSDNNTNGYACMKKEEISDRERWQHLADLADFALAMKVTLMNINYQS 1009

  Fly  1393 FNNFRMRIGINIGPVVAGVIGACKPQYDIWGNAVNVASRMDSTGLVDHIQVTQEMQQILEGRGFE 1457
            ||||.:|||:|.|.|:||||||.||.:|||||.|||||||:|||::.:|||.::...||:..||.
Zfish  1010 FNNFMLRIGLNKGAVLAGVIGARKPHFDIWGNTVNVASRMESTGVMGNIQVVEDCYCILKDYGFR 1074

  Fly  1458 LTCRGSVDVKGKGSMITYFLKGR 1480
            ...||.:.|||||.::|||||||
Zfish  1075 FVRRGPIFVKGKGELLTYFLKGR 1097

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:318454	63/237 (27%)
		Guanylate_cyc	722..904	CDD:425528	116/181 (64%)
		Adcy_cons_dom	<949..1005	CDD:461877	16/59 (27%)
		Guanylate_cyc	1285..1479	CDD:425528	111/206 (54%)
adcy3a	XP_009290286.2	None