DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43373 and adcy7

DIOPT Version :9

Sequence 1:	NP_001097622.2	Gene:	CG43373 / 39835	FlyBaseID:	FBgn0263131	Length:	1854	Species:	Drosophila melanogaster
Sequence 2:	XP_021333246.1	Gene:	adcy7 / 568726	ZFINID:	ZDB-GENE-040713-1	Length:	1119	Species:	Danio rerio

Alignment Length:	1022	Identity:	363/1022 - (35%)
Similarity:	545/1022 - (53%)	Gaps:	178/1022 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   590 IVLIYMTYTMLPLRLREALIGGILLSVVH---LYTCLRLNAMQDEAVEMIHWEELLCTLVALLLA 651
            :.:|...|||||.::..|:|..|:.|:.|   |...|.:..:....:..    :||...|.....
Zfish   129 LFIIITVYTMLPFQMSYAVILSIISSLSHIIVLSVYLTVAQLHSNPITF----QLLSNAVVFGCG 189

  Fly   652 NLTGVYTHWPKEKAQRKAFIETRQCIEARLRTQRENQQQERLLLSVLPRHVAMEM---------- 706
            .:.|::.....|||.::.|.:|.:|:..|::.:.|.:|||.||.||||.:::|:|
Zfish   190 IMVGIFHKVLMEKALKQTFQDTLRCLGIRMKLEIEKRQQENLLQSVLPVYISMKMKLAIMERCKC 254

  Fly   707 --KDDIAGQPRDTQFHKIYIQRHENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAE 769
              |::.....||..||.:|::||||||||:|||.|||.|:..|:.:|||.:|||||.:||::|.|
Zfish   255 KDKEEQQRMVRDNNFHSLYVKRHENVSILYADIVGFTRLASDCSPKELVLMLNELFGKFDQIAKE 319

  Fly   770 HHCLRIKLLGDCYYCVSGLPEPRPDHAHCAVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHC 834
            :.|:|||:||||||||||||...|:||...|:|||||.:||..|||...|::|||||:|:|.|.|
Zfish   320 NECMRIKILGDCYYCVSGLPVSLPNHAKNCVKMGLDMCEAIKQVREATGVDINMRVGVHSGNVLC 384

  Fly   835 GVLGLVKWQFDVWSNDVTLANHMESGGIPGRVHITKETLKCLDGDYEVEVGKGNERNSYLKDHQI 899
            ||:||.||||||||:||||||||||||:|||||||:.|||.|:..||||.|.|:.|::|||:..|
Zfish   385 GVIGLRKWQFDVWSHDVTLANHMESGGLPGRVHITEATLKHLNKAYEVEEGNGHLRDTYLKELNI 449

  Fly   900 ETYLIV----------PGDIYRP----------------------------HKKSRNRL----QV 922
            :|:|::          ...|.:|                            |.:||...    .|
Zfish   450 KTFLVIDPRSKDSSLMAPSITKPRVSDGLKMRASVRMTRFLESWGAVKPFAHLQSREEFNTDAMV 514

  Fly   923 NGNISKELRMMGH------GTAQKHTSKFGFGDS-SESAKDP---------------------ED 959
            ||.        ||      .:...|..     || .||.::|                     ::
Zfish   515 NGK--------GHCKDIPLRSVPTHNP-----DSFDESLEEPFSLPAPPLSTYNRNKSQKTKFDE 566

  Fly   960 EVNEYLMRAID--ARSIDHLRAEHCQSLLLCFKDNVLERKYASEPDRMLCVYFYCSLLVLLGTSI 1022
            |:::.:...|:  :.|...:::|....|.|.|....||.:|.:........|..|:..:.:...|
Zfish   567 ELHDKMTTTINDLSSSKQWVKSEEISGLTLWFTKKDLEMQYRTIEMPNFKYYIGCATFIFICIFI 631

  Fly  1023 MRLVVFQSSL-LTLALSTGALLLLGFLVFLVACHKINFQLPSDIKRFSLRIHSNRRISQ------ 1080
            ::::|.:..: |.|..:..|..||..|....|.| |....|..:|..:..:..::.:.:
Zfish   632 IQMLVTKQRIELGLGFAVLACFLLLILCICFADH-IQRMFPEKLKSCTWLLALSKAVVKRPFVRI 695

  Fly  1081 LFAFASVALIVLTTLLAMF-QESGRQMELLQRRRFWLDVNGSISLNDTELNTKMYDAEEPDCDF- 1143
            |.|..:..:||:..:..:| :::....:|||:                  |:...|:...:..:
Zfish   696 LLATVATTVIVVIAMFELFLKKTDNLCDLLQQ------------------NSSFADSARDELQYL 742

  Fly  1144 -YLAYNTFLLLTLLSMMSCATYQVLRILLKLLLLLLASGSYMACSSNLYSRSREMSQE------- 1200
             ||.||     .:|::::|..:  ||:..:|.|..|...|.::.:..|||:....|..
Zfish   743 PYLVYN-----CILALIACGVF--LRVSFELKLAFLLIVSLVSYTIILYSQENLFSNYNCLLYTN 800

  Fly  1201 -------LANEEALLRY--IIDSIFLFAFMLALIFHSHQTEATYRLDFIWKLQATEEKEDMEHLQ 1256
                   :..:..|:::  |:..|::..|:..::..|.|.|...|.||:.|.:...:||::|..:
Zfish   801 HSCGDSLMVCKAGLMKHPKIMSCIYITLFLFTMLLISRQNEYCCRQDFLLKNKNLADKEEVELCE 865

  Fly  1257 AYNRKLLENILPVHVAEHFLSREKHLD---------------DLYHEQCDSVCILFASIPNFSEF 1306
            ..||.||||:||.|||..|:...|..:               |||::..|.||::|||:|:|.||
Zfish   866 NLNRLLLENVLPAHVAALFVGENKKNEVGLLSAISLLNRKYKDLYYKSYDCVCVMFASVPDFKEF 930

  Fly  1307 YVELEGNNEGVECLRLLNEIIADFDELLSEERFRCIEKIKSTGATYMAASGLTA------NTCDR 1365
            |.|.:.|.||:||||||||||||||||||:.:|..:||||:.|:|||||:||:.      ...:|
Zfish   931 YTECDINKEGLECLRLLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAAAGLSGPPEQSNQDRER 995

  Fly  1366 VNFSHVTAMADYALQLFDKIEEVNMHSFNNFRMRIGINIGPVVAGVIGACKPQYDIWGNAVNVAS 1430
            .| :.:..|.::|:.|..|::.:|.||||.||:|:|||.|||:||||||.|||||||||.|||||
Zfish   996 QN-AQIGNMVEFAIALIGKLDGINRHSFNTFRLRVGINHGPVIAGVIGARKPQYDIWGNTVNVAS 1059

  Fly  1431 RMDSTGLVDHIQVTQEMQQILEGRGFELTCRGSVDVKGKGSMITYFL 1477
            ||:|||.:..||||:|...:|:..|:...|||.::|||||.:.|:|:
Zfish  1060 RMESTGELGKIQVTEETSIVLQNLGYSCECRGLINVKGKGELKTFFV 1106

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:292831	39/144 (27%)
		CYCc	686..881	CDD:214485	121/206 (59%)
		Guanylate_cyc	722..895	CDD:278633	112/172 (65%)
		DUF1053	<949..1005	CDD:283888	15/79 (19%)
		CYCc	1259..1455	CDD:214485	113/216 (52%)
		Guanylate_cyc	1285..1479	CDD:278633	110/199 (55%)
adcy7	XP_021333246.1	AC_N	<129..248	CDD:318454	36/122 (30%)
		Guanylate_cyc	272..455	CDD:306677	117/182 (64%)
		DUF1053	487..613	CDD:310728	24/138 (17%)
		Guanylate_cyc	909..1106	CDD:306677	109/197 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.810