Protein Alignment CG43373 and adcy7

DIOPT Version :10

• Sequence 1: NP_001097622.2
• Gene: CG43373 / 39835
• FlyBaseID: FBgn0263131
• Length: 1854
• Species: Drosophila melanogaster
• Sequence 2: XP_021333246.1
• Gene: adcy7 / 568726
• ZFINID: ZDB-GENE-040713-1
• Length: 1119
• Species: Danio rerio
• Alignment Length: 1022
• Identity: 363/1022 - (35%)
• Similarity: 545/1022 - (53%)
• Gaps: 178/1022 - (17%)

  Fly   590 IVLIYMTYTMLPLRLREALIGGILLSVVH---LYTCLRLNAMQDEAVEMIHWEELLCTLVALLLA 651
            :.:|...|||||.::..|:|..|:.|:.|   |...|.:..:....:..    :||...|.....
Zfish   129 LFIIITVYTMLPFQMSYAVILSIISSLSHIIVLSVYLTVAQLHSNPITF----QLLSNAVVFGCG 189

  Fly   652 NLTGVYTHWPKEKAQRKAFIETRQCIEARLRTQRENQQQERLLLSVLPRHVAMEM---------- 706
            .:.|::.....|||.::.|.:|.:|:..|::.:.|.:|||.||.||||.:::|:|
Zfish   190 IMVGIFHKVLMEKALKQTFQDTLRCLGIRMKLEIEKRQQENLLQSVLPVYISMKMKLAIMERCKC 254

  Fly   707 --KDDIAGQPRDTQFHKIYIQRHENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAE 769
              |::.....||..||.:|::||||||||:|||.|||.|:..|:.:|||.:|||||.:||::|.|
Zfish   255 KDKEEQQRMVRDNNFHSLYVKRHENVSILYADIVGFTRLASDCSPKELVLMLNELFGKFDQIAKE 319

  Fly   770 HHCLRIKLLGDCYYCVSGLPEPRPDHAHCAVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHC 834
            :.|:|||:||||||||||||...|:||...|:|||||.:||..|||...|::|||||:|:|.|.|
Zfish   320 NECMRIKILGDCYYCVSGLPVSLPNHAKNCVKMGLDMCEAIKQVREATGVDINMRVGVHSGNVLC 384

  Fly   835 GVLGLVKWQFDVWSNDVTLANHMESGGIPGRVHITKETLKCLDGDYEVEVGKGNERNSYLKDHQI 899
            ||:||.||||||||:||||||||||||:|||||||:.|||.|:..||||.|.|:.|::|||:..|
Zfish   385 GVIGLRKWQFDVWSHDVTLANHMESGGLPGRVHITEATLKHLNKAYEVEEGNGHLRDTYLKELNI 449

  Fly   900 ETYLIV----------PGDIYRP----------------------------HKKSRNRL----QV 922
            :|:|::          ...|.:|                            |.:||...    .|
Zfish   450 KTFLVIDPRSKDSSLMAPSITKPRVSDGLKMRASVRMTRFLESWGAVKPFAHLQSREEFNTDAMV 514

  Fly   923 NGNISKELRMMGH------GTAQKHTSKFGFGDS-SESAKDP---------------------ED 959
            ||.        ||      .:...|..     || .||.::|                     ::
Zfish   515 NGK--------GHCKDIPLRSVPTHNP-----DSFDESLEEPFSLPAPPLSTYNRNKSQKTKFDE 566

  Fly   960 EVNEYLMRAID--ARSIDHLRAEHCQSLLLCFKDNVLERKYASEPDRMLCVYFYCSLLVLLGTSI 1022
            |:::.:...|:  :.|...:::|....|.|.|....||.:|.:........|..|:..:.:...|
Zfish   567 ELHDKMTTTINDLSSSKQWVKSEEISGLTLWFTKKDLEMQYRTIEMPNFKYYIGCATFIFICIFI 631

  Fly  1023 MRLVVFQSSL-LTLALSTGALLLLGFLVFLVACHKINFQLPSDIKRFSLRIHSNRRISQ------ 1080
            ::::|.:..: |.|..:..|..||..|....|.| |....|..:|..:..:..::.:.:
Zfish   632 IQMLVTKQRIELGLGFAVLACFLLLILCICFADH-IQRMFPEKLKSCTWLLALSKAVVKRPFVRI 695

  Fly  1081 LFAFASVALIVLTTLLAMF-QESGRQMELLQRRRFWLDVNGSISLNDTELNTKMYDAEEPDCDF- 1143
            |.|..:..:||:..:..:| :::....:|||:                  |:...|:...:..:
Zfish   696 LLATVATTVIVVIAMFELFLKKTDNLCDLLQQ------------------NSSFADSARDELQYL 742

  Fly  1144 -YLAYNTFLLLTLLSMMSCATYQVLRILLKLLLLLLASGSYMACSSNLYSRSREMSQE------- 1200
             ||.||     .:|::::|..:  ||:..:|.|..|...|.::.:..|||:....|..
Zfish   743 PYLVYN-----CILALIACGVF--LRVSFELKLAFLLIVSLVSYTIILYSQENLFSNYNCLLYTN 800

  Fly  1201 -------LANEEALLRY--IIDSIFLFAFMLALIFHSHQTEATYRLDFIWKLQATEEKEDMEHLQ 1256
                   :..:..|:::  |:..|::..|:..::..|.|.|...|.||:.|.:...:||::|..:
Zfish   801 HSCGDSLMVCKAGLMKHPKIMSCIYITLFLFTMLLISRQNEYCCRQDFLLKNKNLADKEEVELCE 865

  Fly  1257 AYNRKLLENILPVHVAEHFLSREKHLD---------------DLYHEQCDSVCILFASIPNFSEF 1306
            ..||.||||:||.|||..|:...|..:               |||::..|.||::|||:|:|.||
Zfish   866 NLNRLLLENVLPAHVAALFVGENKKNEVGLLSAISLLNRKYKDLYYKSYDCVCVMFASVPDFKEF 930

  Fly  1307 YVELEGNNEGVECLRLLNEIIADFDELLSEERFRCIEKIKSTGATYMAASGLTA------NTCDR 1365
            |.|.:.|.||:||||||||||||||||||:.:|..:||||:.|:|||||:||:.      ...:|
Zfish   931 YTECDINKEGLECLRLLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAAAGLSGPPEQSNQDRER 995

  Fly  1366 VNFSHVTAMADYALQLFDKIEEVNMHSFNNFRMRIGINIGPVVAGVIGACKPQYDIWGNAVNVAS 1430
            .| :.:..|.::|:.|..|::.:|.||||.||:|:|||.|||:||||||.|||||||||.|||||
Zfish   996 QN-AQIGNMVEFAIALIGKLDGINRHSFNTFRLRVGINHGPVIAGVIGARKPQYDIWGNTVNVAS 1059

  Fly  1431 RMDSTGLVDHIQVTQEMQQILEGRGFELTCRGSVDVKGKGSMITYFL 1477
            ||:|||.:..||||:|...:|:..|:...|||.::|||||.:.|:|:
Zfish  1060 RMESTGELGKIQVTEETSIVLQNLGYSCECRGLINVKGKGELKTFFV 1106

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:318454	39/144 (27%)
		Guanylate_cyc	722..904	CDD:425528	116/181 (64%)
		Adcy_cons_dom	<949..1005	CDD:461877	15/79 (19%)
		Guanylate_cyc	1285..1479	CDD:425528	110/199 (55%)
adcy7	XP_021333246.1	AC_N	<129..248	CDD:318454	36/122 (30%)
		Guanylate_cyc	272..455	CDD:425528	117/182 (64%)
		Adcy_cons_dom	487..615	CDD:461877	24/140 (17%)
		Guanylate_cyc	909..1106	CDD:425528	109/197 (55%)