DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43373 and gucy2cb

DIOPT Version :9

Sequence 1:	NP_001097622.2	Gene:	CG43373 / 39835	FlyBaseID:	FBgn0263131	Length:	1854	Species:	Drosophila melanogaster
Sequence 2:	XP_021329920.1	Gene:	gucy2cb / 568219	ZFINID:	ZDB-GENE-130531-31	Length:	1071	Species:	Danio rerio

Alignment Length:	389	Identity:	96/389 - (24%)
Similarity:	165/389 - (42%)	Gaps:	87/389 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   639 EELLCTLVALLLANLTGVYTHWPKEKAQRKAFIETRQCIEARL--RTQRENQQQERLLLSVLPR- 700
            ||.:|    :|:.|.      |.::..:|..|    :.||..|  ...|:||:.|..:.:::.|
Zfish   708 EEEVC----MLIRNC------WDEDPDRRPDF----KKIEIALWKIVSRDNQEHESYMENLIRRL 758

  Fly   701 -------HVAMEMKDDIAGQPRD------------------TQFHKIYIQRHENVSILFADICGF 740
                   ...:|.:..:....||                  .:..|:..:..:.|:|.|:||.||
Zfish   759 QMYSRNLERLVEERTALYKAERDRADCLNFMLLPGPVVRSLKETGKVEPELFDEVTIYFSDIVGF 823

  Fly   741 TSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEPRPD-HAHCAVEMGL 804
            |:|....|..|:|.:||:::..||.:...|...:::.:||.|..|||||....: ||.....|.|
Zfish   824 TTLCHFSTPMEVVDMLNDIYKNFDSILDNHDVYKVETIGDAYMVVSGLPRRNGNRHAKDICLMAL 888

  Fly   805 DMIDAIALVR--EVMAVNVNMRVGIHTGRVHCGVLGLVKWQFDVWSNDVTLANHMESGGIPGRVH 867
            |::..:..::  .:..:.|.:|:|:|:|....||:|:...::.::.:.|..|:.|||.|:|.|:|
Zfish   889 DILAFMGTIQLSHLPGIPVWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIH 953

  Fly   868 ITKETLKCL---DGDYEVE-------VGKGNERNSYLKDHQIETYLIVPGDIYR-PHKKSRNRLQ 921
            :::.|:..|   |..:|.|       .|||.|...:|..        |.|:.|. |...:....|
Zfish   954 VSQSTINILQRTDCKFEYEERGETFLKGKGKEMTYWLTG--------VTGENYNLPTPPTAENFQ 1010

  Fly   922 VNGNISKELRMMGHGTAQKHTS-------------KFGFGDSSESAKDPE-------DEVNEYL 965
               |:.::|..|.....||..|             |...|...|:...||       |.::.||
Zfish  1011 ---NLQQDLSEMIKTCLQKRPSGLWRRKTLSARHRKLMVGVEMETTDQPEYLHLATGDFLSTYL 1071

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:292831	19/108 (18%)
		CYCc	686..881	CDD:214485	58/226 (26%)
		Guanylate_cyc	722..895	CDD:278633	56/185 (30%)
		DUF1053	<949..1005	CDD:283888	6/24 (25%)
		CYCc	1259..1455	CDD:214485
		Guanylate_cyc	1285..1479	CDD:278633
gucy2cb	XP_021329920.1	Periplasmic_Binding_Protein_Type_1	33..408	CDD:324556
		PKc_like	471..741	CDD:328722	11/46 (24%)
		CYCc	778..970	CDD:214485	53/191 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910