DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43373 and adcy2a

DIOPT Version :9

Sequence 1:	NP_001097622.2	Gene:	CG43373 / 39835	FlyBaseID:	FBgn0263131	Length:	1854	Species:	Drosophila melanogaster
Sequence 2:	XP_692173.5	Gene:	adcy2a / 563724	ZFINID:	ZDB-GENE-061109-1	Length:	1155	Species:	Danio rerio

Alignment Length:	1213	Identity:	443/1213 - (36%)
Similarity:	630/1213 - (51%)	Gaps:	213/1213 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   386 RQKRKHYRRLHKHRYKHK-----SHQQHRTRYRMRE---------KRSLQDAGLVKGGGIQTQLI 436
            |:...|.:.|.:....||     ..::|.|....||         :||.:..|.|||||...:
Zfish    20 RESVVHLKDLCEEHDPHKPQPLYDREEHNTSSMWREAIRKRSYLLERSSKTGGNVKGGGGGVR-- 82

  Fly   437 VDTATDDDADVYTVASDDDDDVDGGRSAGSKHITYTPRVRDYNQISHAERDEVLNTSSNAGVATD 501
                                    ||...|....|.    .|:::|...
Zfish    83 ------------------------GRRQRSPDWLYD----SYHRMSQQH---------------- 103

  Fly   502 NSDPPLGYGQLIPLILMQVDESVLVFLIVMLICGI-VYAFLLCILSKPAMNEIFL---VLV---- 558
                     .||..:|:.|..:.|..|.|....|: :...:..:::.|....|||   |||
Zfish   104 ---------PLIVFLLLIVMGACLALLAVFFASGLDIEDHVAFVITVPTALAIFLTIFVLVCIES 159

  Fly   559 ---------SYVILGTFLAIEVAVSYAMQPSKSFNGSACC--------IVLIYMTYTMLPLRLRE 606
                     |.||.|..    ||:.|...    |.|...|        :.:|::.|||||..:|:
Zfish   160 VFKKLLRVFSLVIWGCL----VAMGYLFM----FFGGIICPWDQVSFFLFIIFVVYTMLPFSMRD 216

  Fly   607 ALIGGILLSVVH---LYTCLRLNAMQDEAVEMIHWEELLCTLVALLLANLTGVYTHWPKEKAQRK 668
            |:|..:|.:..|   |..||......   ||.:.| ::|..::..:..|:.|.|.....|.|.::
Zfish   217 AIIASVLTASSHTVVLSVCLSSTVSH---VEPLVW-QILANVIIFICGNVAGAYHKHLMELALKQ 277

  Fly   669 AFIETRQCIEARLRTQRENQQQERLLLSVLPRHVAMEMKDDIA--------GQPRDT-QFHKIYI 724
            .:.:|..||::.::.:.|.:||||||||:||.|:|..||.:|.        ||..:| .||.:|:
Zfish   278 TYQDTCNCIKSPIKLEFEKRQQERLLLSLLPAHIARVMKAEIIQRLQGPKFGQVENTNNFHNLYV 342

  Fly   725 QRHENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLP 789
            |||.|||||:|||.|||.|:..|:..|||.:|||||.:||::|.|:.|:|||:||||||||||||
Zfish   343 QRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLP 407

  Fly   790 EPRPDHAHCAVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCGVLGLVKWQFDVWSNDVTLA 854
            |..|:||...|:|||||.:||..||:...|.::||||:|:|.|.|||:||.|||:||||:|||||
Zfish   408 ESLPNHAKNCVKMGLDMCEAIKKVRDATGVEISMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLA 472

  Fly   855 NHMESGGIPGRVHITKETLKCLDGDYEVEVGKGNERNSYLKDHQIETYLIV--------PGDIYR 911
            ||||:||:|||||||.|||:.|:|.|:||.|.|.||:.|||:|.:.|||::        |...||
Zfish   473 NHMEAGGVPGRVHITSETLEHLNGAYKVEDGHGQERDPYLKEHGVITYLVINPKVERKSPQHYYR 537

  Fly   912 P-HKKSRNRLQVNGNISKELRMMG---------H-----------GTAQKHTSKFGFGDSSESAK 955
            | |.....:::.:..:::.|...|         |           .||.....::.|...||..|
Zfish   538 PRHTIDGAKMRASVRMTRYLESWGAAKPFANLHHRDSMTNENGKINTADVPIGQYHFQRRSERTK 602

  Fly   956 DP----EDEVNEYLMRAIDARSIDH--LRAEHCQSLLLCFKDNVLERKYASEP-------DRMLC 1007
            ..    |:|:||.::|..|..:...  |::|..|.:.|.|.:..||::|.:..       ....|
Zfish   603 SQKKRFEEELNERMIRTFDGINSQKQWLKSEDIQRISLFFHNKALEKEYRATTLPAFKYYITCAC 667

  Fly  1008 VYFYC----SLLVLLGTSIMRLVVFQSSLLTLALSTGALLLLGFLVFLVACHKINFQLPSDIKRF 1068
            :.|:|    .:|||..|:|:. |.|..|.|.|::    :||:.|:...:.|.|........|.|.
Zfish   668 LIFFCIFIVQILVLPKTAILG-VSFGMSFLILSV----ILLVCFIGHFLQCKKTASASWVWILRS 727

  Fly  1069 SLRIHSNRRISQLFAFASVALIVLTTLLAMFQESGRQMELLQRRRFWLDVNGSISLNDTELNTKM 1133
            |..|.|..........|:.|||::..:..||                 .:..:::|.:|..||..
Zfish   728 SGIIASKPWPRITLTMATTALILIMAVFNMF-----------------FIEDNLTLMETVYNTSN 775

  Fly  1134 YDAEEPDCD---------FYLAYNTFLLLTLLSMMSCATYQVLRILLKLLLLLLASGSYMACSSN 1189
            ....:||..         |||.|  |:...:|.::||:.:..:...||:|::|.|...|......
Zfish   776 ETLLQPDGQPIPYLDKNTFYLPY--FIYSCILGLISCSVFLRINYELKMLIMLTAVVLYSVIILQ 838

  Fly  1190 LY-SRSREMSQELANEEALLR-------YIIDSIFLFAFMLALIFHSHQTEATYRLDFIWKLQAT 1246
            .: |...|.|:.|...|.:.|       ..:.|:.||.|.:.|:..:.|.|...||||:||.:..
Zfish   839 THASLLDEYSKFLYKTEVIERPGVLKDLKTMGSVSLFIFFITLLVLARQNEYYCRLDFLWKNKFK 903

  Fly  1247 EEKEDMEHLQAYNRKLLENILPVHVAEHFLSREKHLDDLYHEQCDSVCILFASIPNFSEFYVELE 1311
            :|.|::|.::..||.||||:||.|||||||:|....:||||:..|.||::|||||:|.|||.|.:
Zfish   904 KECEEIETMENLNRVLLENVLPAHVAEHFLARNWKNEDLYHQSYDLVCVMFASIPDFKEFYTESD 968

  Fly  1312 GNNEGVECLRLLNEIIADFDELLSEERFRCIEKIKSTGATYMAASGLTA-------NTCDRVNFS 1369
            .|.||:||||||||||||||||||:.:|..:||||:.|:|||||:||.|       ...|| .:.
Zfish   969 VNKEGLECLRLLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAATGLNATPGPEYTQEHDR-QYM 1032

  Fly  1370 HVTAMADYALQLFDKIEEVNMHSFNNFRMRIGINIGPVVAGVIGACKPQYDIWGNAVNVASRMDS 1434
            |:..|.::|..|..|::.:|.||||:|::|:|||.|||.||||||.|||||||||.|||||||||
Zfish  1033 HIGTMVEFAFALVGKLDVINKHSFNDFKLRVGINHGPVKAGVIGAQKPQYDIWGNTVNVASRMDS 1097

  Fly  1435 TGLVDHIQVTQEMQQILEGRGFELTCRGSVDVKGKGSMITYFL 1477
            ||::..||||:|...||:..|:..:|||.::|||||.:.|||:
Zfish  1098 TGVLGKIQVTEETSCILQTLGYTCSCRGIINVKGKGELKTYFV 1140

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:292831	66/233 (28%)
		CYCc	686..881	CDD:214485	123/203 (61%)
		Guanylate_cyc	722..895	CDD:278633	110/172 (64%)
		DUF1053	<949..1005	CDD:283888	17/68 (25%)
		CYCc	1259..1455	CDD:214485	121/202 (60%)
		Guanylate_cyc	1285..1479	CDD:278633	116/200 (58%)
adcy2a	XP_692173.5	AC_N	<92..319	CDD:292831	69/267 (26%)
		CYCc	295..498	CDD:214485	123/202 (61%)
		Guanylate_cyc	340..524	CDD:278633	116/183 (63%)
		DUF1053	554..658	CDD:283888	23/103 (22%)
		CYCc	912..1120	CDD:214485	122/208 (59%)
		Guanylate_cyc	942..1141	CDD:278633	116/200 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.810