Protein Alignment CG43373 and adcy5

DIOPT Version :10

• Sequence 1: NP_001097622.2
• Gene: CG43373 / 39835
• FlyBaseID: FBgn0263131
• Length: 1854
• Species: Drosophila melanogaster
• Sequence 2: XP_068079526.2
• Gene: adcy5 / 562619
• ZFINID: ZDB-GENE-081104-470
• Length: 1191
• Species: Danio rerio
• Alignment Length: 1247
• Identity: 530/1247 - (42%)
• Similarity: 740/1247 - (59%)
• Gaps: 164/1247 - (13%)

  Fly   336 MTRGSSIPLLALASNGSWAGNGAVGGELKSAHNHNIA--DFEADHNG----------QLV----- 383
            |:|.:|:         |..|.||.|  |:....|..|  :.|:..||          :|:
Zfish     1 MSRSNSV---------SPPGAGAPG--LRGGTEHRSAWGESESVANGCPYSARSSCKKLIRSNSR 54

  Fly   384 WR------RQKRKHYRRLHKHRYKHKS---HQQHRTRYRMREKRSLQDAGLVKGGGIQTQLIVDT 439
            ||      ||..:....:.:..::.||   .|...:|...|.....:| |.|:...::..|
Zfish    55 WREDDDFERQPGRATTTVSRVSFRSKSAWQEQGEESRNNNRSSPRYRD-GEVRPKSVELGL---- 114

  Fly   440 ATDDDADVYTVASDDDD---DVDGGRSAGSKHITYTPRVRDYNQISHAERDEVLNTSSNAGVATD 501
                 .|..|.:..:::   :|:...||....:....|.:.: |....||
Zfish   115 -----EDRRTKSKPEEELMPEVNFSMSACCNSVMQIFRSKKF-QSEKLER--------------- 158

  Fly   502 NSDPPLGYGQLIPLILMQVDESVLVFL--IVMLICGIVYAF------------------------ 540
                      |......::::|.|..|  :::|:|.::..|
Zfish   159 ----------LYQRYFFRLNQSSLTMLMAVLVLVCAVMLGFHCAGGMCQLTYVLVFTAAIVLILT 213

  Fly   541 LLCILSKPAMNEIFLVLVSYVILGTFLAIEVAVSYAMQPSKSFNGSACCIVLIYMTYTMLPLRLR 605
            |:.:.::...::..:.:|.|:::...||::|.....::|..:..|....:..|::.||:||:|:|
Zfish   214 LMVVCNRNGFHQDHMWIVCYLLILLVLAVQVVGVLFVKPRSASEGIWWTVFFIHVIYTLLPVRMR 278

  Fly   606 EALIGGILLSVVHLYTCLRLNAMQDEAVEMIHWEELLCTLVALLLANLTGVYTHWPKEKAQRKAF 670
            .|:|.||:||.:|:....|||.|     ::..|::|:..::....:|:.||.||:|.|.:||:||
Zfish   279 AAVITGIILSAIHVLISWRLNDM-----DVFLWKQLVSNVLIFSCSNIVGVCTHYPAEGSQRQAF 338

  Fly   671 IETRQCIEARLRTQRENQQQERLLLSVLPRHVAMEMKDDIAGQPRDTQFHKIYIQRHENVSILFA 735
            .|||:||:|||.:||||||||||||||||||||:|||.||..:..|..|||||||:|:|||||||
Zfish   339 QETRECIQARLHSQRENQQQERLLLSVLPRHVALEMKADINAKQEDMMFHKIYIQKHDNVSILFA 403

  Fly   736 DICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEPRPDHAHCAV 800
            ||.|||||:.||||:|||..|||||||||:||||:||||||:|||||||||||||.|.|||||.|
Zfish   404 DIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCV 468

  Fly   801 EMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCGVLGLVKWQFDVWSNDVTLANHMESGGIPGR 865
            |||:|||:||:|||||..||||||||||:||||||||||.||||||||||||||||||:||..||
Zfish   469 EMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGR 533

  Fly   866 VHITKETLKCLDGDYEVEVGKGNERNSYLKDHQIETYLIVPGDIYRPHKKS----RNRLQVN--- 923
            :||||.||..|:|||:||.|.|.|||.|||.|.|||||||.....|..:|:    .||.:.|
Zfish   534 IHITKATLNYLNGDYDVEPGSGGERNVYLKKHNIETYLIVGCSQKRKEEKAMIAKMNRQRTNSVT 598

  Fly   924 -----------------GNISKELRMMG-HGTAQKHTSKFGFGDSSESAKDPEDEVNEYLMRAID 970
                             .::|||::.|| .....||   |.|.::.|:. :|||||:|:|.||||
Zfish   599 HNSTHWTDRPFYNHLNANSVSKEMKRMGFEDPKDKH---FIFRNTQENL-NPEDEVDEFLGRAID 659

  Fly   971 ARSIDHLRAEHCQSLLLCFKDNVLERKYASEPDRMLCVYFYCSLLVLLGTSIMRLVVFQSSLLTL 1035
            |||||.||:||.:..||.|::..||:||:.:.|.....|..|:.||.|....:::::...|.|.:
Zfish   660 ARSIDRLRSEHVKKFLLTFREPDLEKKYSKQVDSSFGAYVVCASLVFLFICFIQIIIVPHSGLMV 724

  Fly  1036 ALSTGALLLLGFLVFLVACHKINFQLPSDIKRFSLRIHSNRRISQLFAFASVALIVLTTLLAMFQ 1100
            ......|::|..::|:.|.:......|..::..|.||..:|..|.|....::.|:.::..:.:|.
Zfish   725 GFYVLCLVVLMVVMFISAIYSCFGFFPIPLQTLSKRIVQSRLNSTLVGVFTIVLVFISAFINIFT 789

  Fly  1101 ESGRQMELLQRRRFWL---DVNGS----ISLNDTELN-TKMYDAEEPDCDFYLAYNTFLLLTLLS 1157
            .|...::....:.|.:   :||..    .|||.|..: .::.::..|.|:|...:::.:||:||
Zfish   790 CSTDDLKTCLGQEFNISPSNVNACHAHFSSLNYTLWSQNRLCNSSSPTCNFPEYFSSCVLLSLL- 853

  Fly  1158 MMSCATYQVLRILLKLLLLLLASGSYMACSS----NLYSR--SREMSQELANEEALLRYIIDS-- 1214
              :|:.:..:..:.||.|:|.....|:....    :|:..  ...|:..||......  |:|:
Zfish   854 --ACSVFLQVSSIGKLFLMLFIEILYVLIMEVPEVSLFDNVDLLVMANALAPNNGTC--IVDTRV 914

  Fly  1215 -------IFLFAFMLALIFHSHQTEATYRLDFIWKLQATEEKEDMEHLQAYNRKLLENILPVHVA 1272
                   :.:..|:|||..|:.|.|:|.||||:||||||||||:||.||||||:||.||||..||
Zfish   915 PLKIVTPVVITVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVA 979

  Fly  1273 EHFLSREKHLDDLYHEQCDSVCILFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDELLSEE 1337
            .|||:||:..|:||::.|:.|.::||||.||||||||||.||||||||||||||||||||::||:
Zfish   980 AHFLARERRNDELYYQSCECVAVMFASISNFSEFYVELEANNEGVECLRLLNEIIADFDEIISED 1044

  Fly  1338 RFRCIEKIKSTGATYMAASGLTANTCDRVNFSHVTAMADYALQLFDKIEEVNMHSFNNFRMRIGI 1402
            :||.:||||:.|:||||||||..:|.|:...||:.|:||||::|.|:::.:|.||||||:|:||:
Zfish  1045 QFRQLEKIKTIGSTYMAASGLNDSTYDKAGRSHIRALADYAMRLMDQMKYINEHSFNNFKMKIGL 1109

  Fly  1403 NIGPVVAGVIGACKPQYDIWGNAVNVASRMDSTGLVDHIQVTQEMQQILEGRGFELTCRGSVDVK 1467
            |:||||||||||.|||||||||.|||||||||||:.:.||||.::.|:|....:.|..||.|.||
Zfish  1110 NMGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPERIQVTTDLYQVLSSYNYTLEYRGVVKVK 1174

  Fly  1468 GKGSMITYFLKG 1479
            |||.|:||||.|
Zfish  1175 GKGEMMTYFLNG 1186

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:318454	79/222 (36%)
		Guanylate_cyc	722..904	CDD:425528	145/181 (80%)
		Adcy_cons_dom	<949..1005	CDD:461877	29/55 (53%)
		Guanylate_cyc	1285..1479	CDD:425528	127/193 (66%)
adcy5	XP_068079526.2	None