Protein Alignment CG43373 and si:ch211-132f19.7

DIOPT Version :10

• Sequence 1: NP_001097622.2
• Gene: CG43373 / 39835
• FlyBaseID: FBgn0263131
• Length: 1854
• Species: Drosophila melanogaster
• Sequence 2: XP_688903.4
• Gene: si:ch211-132f19.7 / 560410
• ZFINID: ZDB-GENE-130530-619
• Length: 1183
• Species: Danio rerio
• Alignment Length: 1032
• Identity: 391/1032 - (37%)
• Similarity: 581/1032 - (56%)
• Gaps: 144/1032 - (13%)

  Fly   525 LVFLIVML-----------ICGIVYAF--LLCIL---SKPAMNEIFLVLVSYVILGTFLAIEV-- 571
            ::|:.:.|           :.|::.|.  ::|:|   .|..|:..:|   .|..|.::|:..|
Zfish   169 IIFIYLALAPEMVDSQHGWLAGLLMALGAIICVLVLTCKGLMSPDYL---RYAGLASWLSQTVQA 230

  Fly   572 --AVSYAMQPSKSFNGSACCIVLIYMTYTMLPLRLREALIGGILLSVVHLYTCLRLNAMQDEAVE 634
              .:.|.::..:|:    ..:..::..||:|||.|..::..|.|.:.:||:.....| ..|.|:.
Zfish   231 LGGLVYGLETDQSW----YVLFTLFAIYTLLPLPLLWSICMGFLTAALHLFVDTFKN-YNDTAIV 290

  Fly   635 MIHWEELLCTLVALLLANLTGVYTHWPKEKAQRKAFIETRQCIEARLRTQRENQQQERLLLSVLP 699
                .:||...:..:..|..|::.|:..::|||:||:|||:|||.|::.:||||:||||::|:||
Zfish   291 ----RKLLAKGLLYMGMNTAGLFIHYLSDRAQRQAFLETRRCIEGRVKMERENQRQERLVMSILP 351

  Fly   700 RHVAMEMKDDIAGQPRD---TQFHKIYIQRHENVSILFADICGFTSLSDQCTAEELVRLLNELFA 761
            |.:||||..|:.....:   .||||.|..::::||||||||.||||||....|:||||.|||||.
Zfish   352 RFIAMEMIGDMTALDDELLPQQFHKTYFHQYKDVSILFADIKGFTSLSMTMPAQELVRTLNELFG 416

  Fly   762 RFDRLAAEHHCLRIKLLGDCYYCVSGLPEPRPDHAHCAVEMGLDMIDAIALVREVMAVNVNMRVG 826
            ||||||.|:||:|||:||||||||||:|||:..||.|.|||||.||:.|..||:.:..:::||:|
Zfish   417 RFDRLAEENHCMRIKILGDCYYCVSGVPEPQTAHARCCVEMGLAMINTIRYVRKELKRDMDMRIG 481

  Fly   827 IHTGRVHCGVLGLVKWQFDVWSNDVTLANHMESGGIPGRVHITKETLKCLDGDYEVEVGKGNERN 891
            ||:|.|.||||||.||||||||.||.:||.:|:||||||:||::.||.||:|.||.|.|:|:|||
Zfish   482 IHSGSVLCGVLGLQKWQFDVWSWDVDVANMLEAGGIPGRIHISRATLDCLEGVYETEEGRGHERN 546

  Fly   892 SYLKDHQIETYLI--VPGDIYRPHKKSRNRLQVNGNISKELRMMGHGTAQKHTSKFGFGDSSESA 954
            .:|:.|:|:|:||  .|.|...|.|..|                        |||   .:::.||
Zfish   547 EFLRKHKIDTFLIRHTPQDDKEPPKVRR------------------------TSK---DETTWSA 584

  Fly   955 KDPED--------------------------------EVNEYLMRAIDARSIDHLRAEHCQSLLL 987
            :.|.|                                |:|:.:.:||:.||.:.:|.||.....|
Zfish   585 ELPFDNIIGMNCILATFTNGSLVHLPNQITPHCAGSREINKRIKQAIEVRSSERMRKEHITPFTL 649

  Fly   988 CFKDNVLERKYASEPDRMLCVYFYCSLLVLLGTSIMRLVVFQSSLLTLALSTGALLLLGFLVFLV 1052
            .|||..:|.|::...|.|......||.|:||.....:.::.......:.:.....|.:..||.||
Zfish   650 VFKDTHIEGKFSQMRDEMFKSNLACSFLLLLFIMAAQALIPSPQFFPMIIQFLVFLFVYMLVLLV 714

  Fly  1053 ACHKINFQLPSDIKRFSLRIHSNRRISQLFAFASVALIVLTTLLAMFQESGRQMELLQRRRFWLD 1117
            ...:...:.|..::.....||..:.|..|....::|:               ...:.....||
Zfish   715 TLAEEFKRSPPYLQHLCCWIHETKSIRNLLTLTAIAI---------------NFGVASCNIFW-- 762

  Fly  1118 VNGSISLNDTELNTKMYD---------AEEPDCDFYLAYNTFLLLTLLSMMSCATYQVLRILLKL 1173
            .||  :..:||.:.|..:         ...|:        .|:|..:::|::||.:..|..||||
Zfish   763 CNG--TFEETEKSNKNSEHGKQWPVNICTHPE--------FFVLSGVVAMVTCAVFLRLSCLLKL 817

  Fly  1174 --LLLLLASGSYM--ACSSNLYSRSREMSQELANEEALLRYIIDSIFLFAFMLALIFHSHQTEAT 1234
              |.|::|..:|:  .....|:.|..:.|| :...:.|.|..|..:.:..|::.::::|.|.|.|
Zfish   818 AVLTLVIAVYTYLIEVAFHVLFIRQHQNSQ-IQRSQYLRRKGISVLLMAMFVVVVLYNSRQLETT 881

  Fly  1235 YRLDFIWKLQATEEKEDMEHLQAYNRKLLENILPVHVAEHFLSREKHLDDLYHEQCDSVCILFAS 1299
            .||||:|:|||.:|.|||:.|:.:|..||.||||.|||.|||.|:::.:||:.|..:.|.::|||
Zfish   882 SRLDFLWRLQARQEVEDMKELREHNECLLYNILPAHVARHFLERDRNNEDLFSESYERVGVMFAS 946

  Fly  1300 IPNFSEFYVELEGNNEGVECLRLLNEIIADFDELLSEERFRCIEKIKSTGATYMAASGLT--ANT 1362
            ||.||::|.:.|..::.||||||||||||||||||.|..|:.|||||:.|:.|||||||:  ...
Zfish   947 IPGFSDYYEKKELIHQDVECLRLLNEIIADFDELLDEPYFQDIEKIKTIGSCYMAASGLSPEKQE 1011

  Fly  1363 CDRVNFSHVTAMADYALQLFDKIEEVNMHSFNNFRMRIGINIGPVVAGVIGACKPQYDIWGNAVN 1427
            |:. .::|::.:..:||.:.:.::|:|..:.|:|.:|:||:.||||||||||.||||||||..||
Zfish  1012 CED-EWAHLSTLVLFALAMQETLKEINKRTSNDFWLRVGISHGPVVAGVIGATKPQYDIWGMTVN 1075

  Fly  1428 VASRMDSTGLVDHIQVTQEMQQILEGRGFELTCRGSVDVKG----KGSMITYFLKGR 1480
            :|||||||||...|||.:...::|...||.|..||.:.|||    :|::.|||:..|
Zfish  1076 LASRMDSTGLSGRIQVPEATSRVLAEHGFMLQLRGEIYVKGVSERRGAVRTYFVSSR 1132

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:318454	63/217 (29%)
		Guanylate_cyc	722..904	CDD:425528	114/181 (63%)
		Adcy_cons_dom	<949..1005	CDD:461877	20/87 (23%)
		Guanylate_cyc	1285..1479	CDD:425528	101/199 (51%)
si:ch211-132f19.7	XP_688903.4	AcyC	162..539	CDD:441717	170/381 (45%)
		Guanylate_cyc	378..559	CDD:425528	114/180 (63%)
		Adcy_cons_dom	579..668	CDD:461877	20/88 (23%)
		Guanylate_cyc	932..1131	CDD:425528	101/199 (51%)