DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43373 and ADCY10

DIOPT Version :9

Sequence 1:	NP_001097622.2	Gene:	CG43373 / 39835	FlyBaseID:	FBgn0263131	Length:	1854	Species:	Drosophila melanogaster
Sequence 2:	NP_060887.2	Gene:	ADCY10 / 55811	HGNCID:	21285	Length:	1610	Species:	Homo sapiens

Alignment Length:	808	Identity:	158/808 - (19%)
Similarity:	273/808 - (33%)	Gaps:	281/808 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   723 YIQRHENVSILFADICGFTSLSDQCTAEEL--------------VRL----LNELFARFDRLAAE 769
            |:.....|:|:|.::    ...||..|||:              :::    :|::| .||:
Human   285 YLSELRPVTIVFVNL----MFEDQDKAEEIGPAIQDAYMHITSVLKIFQGQINKVF-MFDK---- 340

  Fly   770 HHCLRIKLLGDCYYCVSGLP-EPRPDHAHCAVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVH 833
                     |..:.||.|.| |..||....|:|..:|:.|..:.|.::..|:    :|:.:|.|.
Human   341 ---------GCSFLCVFGFPGEKVPDELTHALECAMDIFDFCSQVHKIQTVS----IGVASGIVF 392

  Fly   834 CGVLG-LVKWQFDVWSNDVTLANHM-------------------------------------ESG 860
            ||::| .|:.::.|....|.||..|                                     :||
Human   393 CGIVGHTVRHEYTVIGQKVNLAARMMMYYPGIVTCDSVTYNGSNLPAYFFKELPKKVMKGVADSG 457

  Fly   861 GIP---GRVHITKETLKCL----DGDYEVEVGKGNERNSYLKDHQIETYLIVPGDIYRPHKKSRN 918
            .:.   ||.......:.||    ..||.: :|:..|.|.::  :.::.:||            .|
Human   458 PLYQYWGRTEKVMFGMACLICNRKEDYPL-LGRNKEINYFM--YTMKKFLI------------SN 507

  Fly   919 RLQVNGNISKELRMMGHGTAQKHTSKFGFGDSSESAKDPEDEVNEYLMRA----IDARSIDHLRA 979
            ..||         :|..|..       |:|.|....|      .|||.:.    |.|.|::.:..
Human   508 SSQV---------LMYEGLP-------GYGKSQILMK------IEYLAQGKNHRIIAISLNKISF 550

  Fly   980 EHCQSLLLCFKDNVL---------ERK--YASEPDRMLCVYFYCSL------------------- 1014
            ......:..|..|||         ||:  ..::...:|...|||.|
Human   551 HQTFYTIQMFMANVLGLDTCKHYKERQTNLRNKVMTLLDEKFYCLLNDIFHVQFPISREISRMST 615

  Fly  1015 ------LVLLGTSIMRLVVFQSSLLTLALSTGALLLLGFLVFLVACHKINFQLPSDIKRFSLRIH 1073
                  |.:|...|::|:|.:..                ::|::  .:..| :.|...||..::
Human   616 LKKQKQLEILFMKILKLIVKEER----------------IIFII--DEAQF-VDSTSWRFMEKL- 660

  Fly  1074 SNRRISQLFAFASVALIVLTTLLAMFQESGRQMELLQRRRFWLDVNGSISLND------TELNTK 1132
              .|...:|...|:...|.....|       ...:::.|.....|.|::..||      .:||..
Human   661 --IRTLPIFIIMSLCPFVNIPCAA-------ARAVIKNRNTTYIVIGAVQPNDISNKICLDLNVS 716

  Fly  1133 MYDAEEPDCDFYLAYNTFLLLTLLSMMSCATYQVLRILLKLLLLLLASGSYMACSSNLYSRSREM 1197
            ....|   .|.||...           ||........|||                ||......:
Human   717 CISKE---LDSYLGEG-----------SCGIPFYCEELLK----------------NLEHHEVLV 751

  Fly  1198 SQELANEEALLRYIIDSIFLFAFMLALIFHSHQTEATYRLDFIWKLQATEEKEDMEHLQAYNRKL 1262
            .|:..:||...| ..:::|.::..|           |.:|:.: .|.:.:|.|::.||.:..|
Human   752 FQQTESEEKTNR-TWNNLFKYSIKL-----------TEKLNMV-TLHSDKESEEVCHLTSGVR-- 801

  Fly  1263 LENIL-PVHVAEHFLSREKHLDD--LYHE---QCDSVC-------ILFASIPNFS-EFYVE---- 1309
            |:|:. |..:.|..|.:   ||.  |.|:   :|.::.       :||..:|.:: :..::
Human   802 LKNLSPPTSLKEISLIQ---LDSMRLSHQMLVRCAAIIGLTFTTELLFEILPCWNMKMMIKTLAT 863

  Fly  1310 -LEGN-----NEGVECLRLLNEIIADFDELLSEERFRCIEKIKSTGATYMAASGL-----TANTC 1363
             :|.|     ..|.|..:.|.:....|     |..:|.:....|.|..:.....|     ....|
Human   864 LVESNIFYCFRNGKELQKALKQNDPSF-----EVHYRSLSLKPSEGMDHGEEEQLRELENEVIEC 923

  Fly  1364 DRVNFSHVTAMADYALQLFDKIEEVNMH 1391
            .|:.|.: ..|...|.:|:.|.:...||
Human   924 HRIRFCN-PMMQKTAYELWLKDQRKAMH 950

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:292831
		CYCc	686..881	CDD:214485	46/221 (21%)
		Guanylate_cyc	722..895	CDD:278633	50/235 (21%)
		DUF1053	<949..1005	CDD:283888	14/70 (20%)
		CYCc	1259..1455	CDD:214485	34/162 (21%)
		Guanylate_cyc	1285..1479	CDD:278633	26/133 (20%)
ADCY10	NP_060887.2	CHD	40..214	CDD:143636
		AcyC	<42..197	CDD:225025
		CHD	292..461	CDD:143636	40/190 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900