Protein Alignment CG43373 and adcy1a

DIOPT Version :9

• Sequence 1: NP_001097622.2
• Gene: CG43373 / 39835
• FlyBaseID: FBgn0263131
• Length: 1854
• Species: Drosophila melanogaster
• Sequence 2: NP_001161821.1
• Gene: adcy1a / 557026
• ZFINID: ZDB-GENE-070705-302
• Length: 1114
• Species: Danio rerio
• Alignment Length: 1108
• Identity: 429/1108 - (38%)
• Similarity: 611/1108 - (55%)
• Gaps: 177/1108 - (15%)

  Fly   525 LVFLIVMLICGIVYAFLLCILSKPAMNEI--FLVLVSYVILGTFLAIEVAVSYAMQ-------PS 580
            ::|..:.::..:.|      |....:.:|  ..:|.|:..........:|:.:..|       ||
Zfish    91 VIFTSLFIVTNVKY------LQVTQLQQIARLALLFSFTFALLCCPFPLALGHGTQGTHGPDAPS 149

  Fly   581 KSFNGSACCIVLI-YMTYTMLPLRLREALIGGILLSVVH-LYTCLRLNAMQDEAVEMIHWEELLC 643
            .:.......::|: ::.|::||:|...|::.|:|::..| :.|...:.|.:...     |..|:.
Zfish   150 TTPEQGVWQLMLVTFVAYSLLPVRTLLAVLFGVLVAASHFIVTATSVTARRPRV-----WTPLVA 209

  Fly   644 TLVALLLANLTGVYTHWPKEKAQRKAFIETRQCIEARLRTQRENQQQERLLLSVLPRHVAMEMKD 708
            ..|.|:..||:||:.....|:||||||::.|.||:.||:.:.||::|||||:|:|||:||||||:
Zfish   210 NAVLLVGVNLSGVFVRVRTERAQRKAFLQARNCIQQRLQLEDENEKQERLLMSLLPRNVAMEMKE 274

  Fly   709 DIAGQPRDTQFHKIYIQRHENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCL 773
            |.. :|.:..|||||||||:|||||||||.|||||:.||||:|||:||||||.:||.||.|:||.
Zfish   275 DFL-KPPERIFHKIYIQRHDNVSILFADIVGFTSLASQCTAQELVKLLNELFGKFDELATENHCR 338

  Fly   774 RIKLLGDCYYCVSGLPEPRPDHAHCAVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCGVLG 838
            |||:|||||||||||.:|:.|||||.|||||||||.|..|.|...|::|||||:|||||.|||||
Zfish   339 RIKILGDCYYCVSGLTQPKADHAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTGRVLCGVLG 403

  Fly   839 LVKWQFDVWSNDVTLANHMESGGIPGRVHITKETLKCLDGDYEVEVGKGNERNSYLKDHQIETYL 903
            |.|||:|||||||||||.||:||:||:|||||.||:||:||||||.|.|:||:::|..|.|||:.
Zfish   404 LRKWQYDVWSNDVTLANMMEAGGLPGKVHITKATLECLNGDYEVEPGFGHERHAFLSKHAIETFF 468

  Fly   904 IVP------------GDIYRPHKKSRNR---------LQVNGNISKELRMMGHGTAQKHTSKFGF 947
            |||            .|| :|.|:...:         :........|:......|.:....:...
Zfish   469 IVPSHRRKIFPGLILSDI-KPAKRMEFKTVCYLLVQLMHCRKMFKAEIPFSNVMTCEDDDKRRAL 532

  Fly   948 GDSSESAKD------------PEDEVNEYLMRAIDARSIDHLRAEHCQSLLLCFKDNVLERKYAS 1000
            ..:||..::            |...||.|:.|.|:||..:...|: ...:.|.::....|::|
Zfish   533 RTASEKLRNRTSFSAGMVQNSPGTRVNRYIGRLIEARQTESEMAD-LNYITLTYRSREREQRY-- 594

  Fly  1001 EPDRMLCVY---FYCSLLV-LLGTSIMRLVVFQSSLLTLALSTGALLLLGFLVFLVAC------- 1054
                 |.||   |..:::: |:.||...:|.|      |.:..|.|:::  |:.|..|
Zfish   595 -----LQVYDDAFISAVVISLVLTSFFAVVYF------LIIPQGLLVVI--LLVLCLCFHMASVM 646

  Fly  1055 --HKINFQLPSDIKRFSLRIHSNRRISQLFAFASVALIVLTTLLAMFQESGRQMELLQRRRFWLD 1117
              |..:.|...|.....:|                  .||...|.:...|..|..::....:.|:
Zfish   647 YLHVTHVQCSPDCLTLQIR------------------TVLCGFLVLLMYSVTQGCVVTCVPWSLE 693

  Fly  1118 VNGSISL------NDTELNTKMYDAEEPDCDFYLAYNTFLLLT-LLSMMSCATYQVLRILLKLLL 1175
            .|.|||:      |.|.:..::       |    .|..::.|: :::.:|.|.|..:..|.|:||
Zfish   694 GNSSISMVTVVTVNGTGVGYRV-------C----KYTPYVFLSCVMASLSVALYLRVSSLPKILL 747

  Fly  1176 LLL----------ASGSYMACSSNLYSRSREMSQELANEEALLRYIIDSIFLFAFMLALIFHSHQ 1230
            |||          .||...|.....: .:......||              :..|..||:.|..|
Zfish   748 LLLLNILHTVVMETSGYRKAVGGGFF-HTHGYDPVLA--------------MLLFSGALVLHCRQ 797

  Fly  1231 TEATYRLDFIWKLQATEEKEDMEHLQAYNRKLLENILPVHVAEHFLSREKHLDDLYHEQCDSVCI 1295
            .:...|||::|..||.||::|||.::..|:::|.|:||.|||:|||.......|||::....|.:
Zfish   798 LDLKLRLDYLWATQAEEERDDMERVKLDNKRILFNLLPAHVAQHFLLSNPRNMDLYYQSYSQVGV 862

  Fly  1296 LFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDELLSEERFRCIEKIKSTGATYMAASGLTA 1360
            ||||||||::||:||:|||.||||||||||||||||.|:.:|.:|.|||||:.|:|||||.||..
Zfish   863 LFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDALMDKECYRDIEKIKTIGSTYMAAVGLVP 927

  Fly  1361 NTCDRVNFS---HVTAMADYALQLFDKIEEVNMHSFNNFRMRIGINIGPVVAGVIGACKPQYDIW 1422
            ....:|..|   |:..:||||:::||.::.:|..|:|:|.:|:|||:||||||||||.:||||||
Zfish   928 TEGSKVKKSISAHLCTVADYAIEMFDVLDAINYQSYNDFVLRVGINVGPVVAGVIGARRPQYDIW 992

  Fly  1423 GNAVNVASRMDSTGLVDHIQVTQEMQQILEGRGFELTCRGSVDVKGKGSMITYFLKGRRPIDAKE 1487
            ||.|||||||||||:...||||:::.::|.|. ::..|||.|.|||||.|:||||:||.|..|:.
Zfish   993 GNTVNVASRMDSTGVQGKIQVTEDVFRLLSGY-YDFNCRGQVSVKGKGQMLTYFLEGRTPQGAQH 1056

  Fly  1488 LELAKTEVEPPKTLTLAKEPE---------KLDSGTATEK---QREQVKEQGSTEQEDDLLPSPD 1540
                          :.:|.|:         ||.|..|...   :...|...|::......|||..
Zfish  1057 --------------SRSKSPDQDSSPCIRTKLGSAPAVSSYGVKSHTVGHVGTSNNSILYLPSVS 1107

  Fly  1541 IDM 1543
            :||
Zfish  1108 VDM 1110

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:292831	60/205 (29%)
		CYCc	686..881	CDD:214485	142/194 (73%)
		Guanylate_cyc	722..895	CDD:278633	128/172 (74%)
		DUF1053	<949..1005	CDD:283888	14/67 (21%)
		CYCc	1259..1455	CDD:214485	114/198 (58%)
		Guanylate_cyc	1285..1479	CDD:278633	116/196 (59%)
adcy1a	NP_001161821.1	AC_N	<154..285	CDD:292831	50/136 (37%)
		CYCc	251..446	CDD:214485	142/195 (73%)
		Guanylate_cyc	287..469	CDD:278633	133/181 (73%)
		DUF1053	513..601	CDD:283888	19/95 (20%)
		CYCc	819..1029	CDD:214485	116/210 (55%)
		Guanylate_cyc	852..1048	CDD:278633	116/196 (59%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D46761at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.720