Protein Alignment CG43373 and ACXA

DIOPT Version :9

• Sequence 1: NP_001097622.2
• Gene: CG43373 / 39835
• FlyBaseID: FBgn0263131
• Length: 1854
• Species: Drosophila melanogaster
• Sequence 2: NP_620475.2
• Gene: ACXA / 53432
• FlyBaseID: FBgn0040510
• Length: 1112
• Species: Drosophila melanogaster
• Alignment Length: 1165
• Identity: 301/1165 - (25%)
• Similarity: 509/1165 - (43%)
• Gaps: 283/1165 - (24%)

  Fly   517 LMQVDESVLVFLIVMLICG---IVYAF-----------------LLCILSKPAMN--EIFLV--- 556
            ||....:|.|.::::||..   |:::|                 |:.:....::|  |.|::
  Fly    53 LMISSLTVFVPMLILLIVALQVIIWSFTEYTKYIYINAIFDLGSLILVTGLLSINFFEDFVIRHR 117

  Fly   557 --------LVSYVILGTFLAIEVAVSYAMQ-PSKSFNGSACCIVLIYMTYTMLPL-RLREALIGG 611
                    |.:||::...:|......|... |..:...    :.::.|.|..||: ..:.|.:..
  Fly   118 WVMTFTSTLSAYVVVLGDIAFNTYYYYKSNWPLNTLYD----VFVLCMIYMFLPIPSSKAAALLA 178

  Fly   612 ILLSVVHLYTCLRLNAMQDEAV-EMIHWEELL-CTLVALLLANLTGVYTHWPKEKAQRKAFIETR 674
            |.:|:.::...:...|..:..| :.:|..::: ......|..|:.|::.....:...|.:|::..
  Fly   179 ISVSLTYVIYFIHFMAFNEHNVAKYVHGLDIVSIDFFHYLGFNMMGIFFRIMNDTMVRSSFLDRY 243

  Fly   675 QCIEARLRTQRENQQQERLLLSVLPRHVAMEMKDDIAG---QPRDTQFHK---------IYIQRH 727
            |.|...:..::..:|:..||.|:||..:|..::..|..   ||.:..:|.         :.||.|
  Fly   244 QFITEEIWLRQARRQESLLLDSILPPQIAKPIQKSIKEKIIQPDNDFYHLGTSRTAENFMSIQIH 308

  Fly   728 ENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEPR 792
            .:||||:||:..:|.|:...|.|:||::|::|:||||..|......|||.||||||||:||.|..
  Fly   309 NDVSILYADLVNYTQLTTTLTVEKLVKVLHDLYARFDLAALSFKVQRIKFLGDCYYCVAGLGESD 373

  Fly   793 PDHAHCAVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCGVLGLVKWQFDVWSNDVTLANHM 857
            ||||..||.:|:.||..|..|....::|:.||:|:|:|.:..||:|..|.|:|:|..||.:|:.:
  Fly   374 PDHATMAVSLGISMIANIKEVSVNRSLNIGMRIGVHSGTLFAGVIGKAKLQYDIWGADVNIASRL 438

  Fly   858 ESGGIPGRVHITKETLKCLDG-DYEVEVG-KGNERNSYLKDHQIETYLI---------------- 904
            |:.|.||.||::..||..|:. :|.:..| :..:::..|:.|.:.|||:
  Fly   439 EATGSPGYVHVSGRTLSSLNAEEYNIYPGTESAQKDPVLQKHPMSTYLLTAIPSLDSDKTISIVE 503

  Fly   905 -VPG-DIYRPHKKSRNRLQVNGNISKELRMMGHGTAQKHTSKFGFGDSSESAKDPEDEVNEYLMR 967
             ||. |:.......::::.....:|.|:|                   .|..|.|   |..:..:
  Fly   504 GVPNLDLQTVGSNRKSQILKPNLLSHEMR-------------------EEFRKMP---VGGFKFQ 546

  Fly   968 AIDARSIDHLRAEHCQSLL----LCFKDNVLERKYASEPDRMLCVYFYCSLLVLLGTSI-MRLVV 1027
            ...:|...:|:.|..:..|    :.|||..:|..|..:||     |.: ...|.||..| ..|:.
  Fly   547 FPWSRRERNLKNEKVERDLGIFCVAFKDKSVEWNYLHQPD-----YIF-KYSVALGWGIGCCLIY 605

  Fly  1028 FQSSLLTLALSTG------ALLLLGFLVFLVACHKINFQLPSDIKRFSLRIHSNRRISQLFAFAS 1086
            .||...:....||      |..:|.||:|:....|:.:.            ||.:...:.:...|
  Fly   606 IQSVNNSDIFYTGVVINIIAFFVLTFLLFICWYKKVCWW------------HSGQNEHRSYGKLS 658

  Fly  1087 VAL----------------IVLTTLLAMFQESGRQMELLQRRRFWLDVNGSISLNDTELNTKMYD 1135
            .|:                :.:..:|..:......:...::.::.||:          :.:|:|:
  Fly   659 CAIFHLFEKIQHSFVLRLTVYMMIILCYYMVISLILMSCEKDQYELDI----------IESKLYN 713

  Fly  1136 AEEPDCDFYLAYNTFLLLTLLSMMSCATYQVLRILLKLLLLLLASGSYMACSSNLYSRSREMSQE 1200
            .   |.|.:..::.:....:::::...:|...||...|       .:::.|:
  Fly   714 Y---DMDPFTCFHPWAYTNMMALILGMSYTFARIPFAL-------KTFIGCA------------- 755

  Fly  1201 LANEEALLRYIIDSIFLFAFML-----------ALIFHS------------------HQTEATYR 1236
                ||:: :::...|.:||:.           |.|.||                  ..|:..|:
  Fly   756 ----EAVV-FVLVVCFQYAFIFEHSVTTSPYLKAEIAHSCRVCMMLITMYAKERQSEFNTKMNYK 815

  Fly  1237 LDFIWKLQATEEKEDMEHLQAYNRK---LLENILPVHVAEHFLSR-EKHLDDLYHEQCDSVCILF 1297
            |:.  .||..::..|:.     |:.   ||.||||.||.|.:||. .||  :||:|....|.::|
  Fly   816 LNL--DLQNKQKSADVT-----NQSIIILLNNILPSHVVEVYLSSIAKH--ELYYENYRMVSVMF 871

  Fly  1298 ASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDELLSE-ERFRCIEKIKSTGATYMAASGLTAN 1361
            |.:.||.   ::|..       ||:||:||..||.|||. :::..:||||..|.|||||.||..:
  Fly   872 AMLTNFQ---MDLPS-------LRVLNDIITAFDRLLSAYKQYYVVEKIKVVGCTYMAACGLDFS 926

  Fly  1362 TCDRV----NFSHVT--------------------------AMADYALQLFDKIEEVNM------ 1390
            ..:.:    ||...:                          .||.:||.|...:...|.
  Fly   927 LIENLDSNSNFGSTSLSSELEQVRSRLESSIKEKNHDEVAFIMATFALDLMRVLSVCNKAYAGEP 991

  Fly  1391 --HSFNNFRMRIGINIGPVVAGVIGACKPQYDIWGNAVNVASRMDSTGLVDHIQVTQEMQQILEG 1453
              .:.:...:||||:.|.::|||:||.:|.||||||.||:||||:||||..|||||:|..|.||
  Fly   992 FDRALSTGEIRIGISTGQIMAGVVGASQPHYDIWGNPVNMASRMESTGLSGHIQVTKETAQTLE- 1055

  Fly  1454 RGFELTC--RGSVDVKGKGSMITYFLKGRRPIDAKELELAKTEVEPPKTLTLAKEPEKLD 1511
             .|::.|  ||...|||:|.:.|||:    .|| |:|:....:::     .|::.|...|
  Fly  1056 -EFDVMCYYRGLTFVKGRGEIPTYFV----GID-KDLKFMSKKID-----RLSENPSNPD 1104

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:292831	43/236 (18%)
		CYCc	686..881	CDD:214485	83/207 (40%)
		Guanylate_cyc	722..895	CDD:278633	74/174 (43%)
		DUF1053	<949..1005	CDD:283888	15/59 (25%)
		CYCc	1259..1455	CDD:214485	90/238 (38%)
		Guanylate_cyc	1285..1479	CDD:278633	87/234 (37%)
ACXA	NP_620475.2	AC_N	<42..291	CDD:292831	45/241 (19%)
		CYCc	262..464	CDD:214485	83/201 (41%)
		Nucleotidyl_cyc_III	306..489	CDD:299850	78/182 (43%)
		CYCc	831..1055	CDD:214485	88/235 (37%)
		Nucleotidyl_cyc_III	859..1080	CDD:299850	86/232 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453941
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D57794at33392
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850