Protein Alignment CG43373 and ACXE

DIOPT Version :9

• Sequence 1: NP_001097622.2
• Gene: CG43373 / 39835
• FlyBaseID: FBgn0263131
• Length: 1854
• Species: Drosophila melanogaster
• Sequence 2: NP_652601.3
• Gene: ACXE / 53426
• FlyBaseID: FBgn0040506
• Length: 1123
• Species: Drosophila melanogaster
• Alignment Length: 1095
• Identity: 305/1095 - (27%)
• Similarity: 508/1095 - (46%)
• Gaps: 220/1095 - (20%)

  Fly   515 LILMQVD-ESVLVFLIVMLI-CGIVYAFLLCILSKPAMNEIFLVLVSYVILGTFLAIEVAVSYAM 577
            |:|..:: .|::.|.:.:.| |.:|   |:.:||....:| |:...::.:..:.:...:.:.:|.
  Fly    65 LLLATIERRSIIYFDVALSIGCALV---LILVLSVNFCDE-FIAKHTWYMYASSIFASLTLVFAD 125

  Fly   578 QPSKSFN--------GSACCIVLIYMTYTMLPLRLREALIGGILLSVV-----HLYTCL------ 623
            .....::        |:.....:|||.|..||:..   :.|.:||:::     .||..:
  Fly   126 LTESIYHTYAHSWILGTFYDTYIIYMIYMFLPIHF---ISGAVLLALLVSGLYILYFVIFIAQGF 187

  Fly   624 -----RLNAMQDEAVEMIHWEELLCTLVALLLANLTGVYTHWPKEKAQRKAFIETRQCIEARLRT 683
                 .|.::...:|:::|:   ||       .||.|::.....:...|.:|::..|.|:.::..
  Fly   188 AQFASALFSVGGMSVDIVHY---LC-------LNLVGIFYRVMNDTVVRSSFLDRHQYIKEKIWL 242

  Fly   684 QRENQQQERLLLSVLPRHVAMEMKDDIAGQ--PRDTQFHK-------IYIQRHENVSILFADICG 739
            :....|:::||.|:||..:::.::.||.|:  ......|.       :.||.|.:||||:||:..
  Fly   243 RNARLQEKQLLDSILPPQISLPLQKDIQGRIVMAKQGIHSWTAMERTMAIQIHPDVSILYADVVN 307

  Fly   740 FTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEPRPDHAHCAVEMGL 804
            :|.|:...|.|.||::|::|:.|||..|..:...|||.||||||||:||.:|.||||:..|.:||
  Fly   308 YTHLTTTLTVEMLVKVLHDLYGRFDLAAYRYKVQRIKFLGDCYYCVAGLSDPDPDHANNCVILGL 372

  Fly   805 DMIDAIALVREVMAVNVNMRVGIHTGRVHCGVLGLVKWQFDVWSNDVTLANHMESGGIPGRVHIT 869
            .||:.|..||::..:::|||:|:|:|.:..||:|..|.|||:|..|||:||.:||.|:||.|||:
  Fly   373 SMINHIMEVRDIHGLDINMRIGVHSGNLFAGVIGEAKLQFDIWGLDVTIANVLESTGVPGCVHIS 437

  Fly   870 KETLKCLD-GDYEVEVGKGNER-NSYLKDHQIETYLIVPGDIYRPHKKSRNRL------------ 920
            ..||..|| ..:::|.|....| :..||.::|.:| |:..|::...:.|...|
  Fly   438 GATLNNLDVNRFDIEDGPEEARDHPLLKKYRIRSY-IIRQDLHMDDEDSDEFLGDLHSISLCNMG 501

  Fly   921 ---QVNGNISKELRMMGHGTAQKHTSKFGFGDSSESAKDPEDEVNEYLMRAIDARSIDHLRAEHC 982
               :::.:.::.||.:.|...::.     |.....||..|     :.|:......:...:.|...
  Fly   502 AQPRISDSANQSLRALFHEELREE-----FRKMPVSAFSP-----KRLLGICRFNTGKEVPAHQN 556

  Fly   983 QSLLLCFKDNVLERKYASEPDRMLCVYFY---------CSLLVLLGTSIMRLVVFQSSLLTLALS 1038
            .::.|.|.|.:|||.|..:.|.|   |.|         |||:.:   .:|...:..||...|..|
  Fly   557 LNICLTFTDPILERAYLKQTDYM---YKYSIILSASVGCSLVYI---ELMDTQMICSSCFVLPAS 615

  Fly  1039 TGALLLLGFLVFLVACHKI-------NFQLPSDIKRFS---LRIHSN-------RRISQLFAFAS 1086
            ...:..   ::.|:|.:|.       ...:|.....||   .|||..       |....||...|
  Fly   616 VATIQC---ILALIAWYKKYCWTRYGRNNVPHHYNGFSCFIFRIHDKILNSLPIRICIYLFLMIS 677

  Fly  1087 VALIVLTTLLAMFQESGRQMELLQRRRFWLDVNGSISLNDTELNTKMYDAEEPDCDFYLAYNTFL 1151
             :..|:..::...|....:|..::.|.|                  .|:.|.     ::.::.::
  Fly   678 -SFFVMCLIVMSCQREEFEMAYIEERLF------------------HYEQEA-----HICFHPWV 718

  Fly  1152 LLTLLSMMSCATYQV--LRILLKLLLLLLASGSYM-------------ACSSNLYSRSREMSQEL 1201
            ...:||:|.|.|:..  :.|::|..:.:|.:.:|:             :.::|.|.:|     |.
  Fly   719 TTNMLSLMICLTFTFAHIPIMVKTAVAILETLAYLLLIFFQFDFVFHHSVTTNPYFKS-----EY 778

  Fly  1202 ANEEALLRYIIDSIFLFAFMLALIFHSHQTEATYRLDFIWKLQATEEKEDMEHLQAYNRKLLENI 1266
            |:  |||   |...||..|:     ...|.|.|.:::|.|::...:|:............:|.||
  Fly   779 AH--ALL---ICITFLIMFV-----KERQIEFTNKVNFNWRVDLRKEENAASLTNHSIIIILNNI 833

  Fly  1267 LPVHVAEHFL-SREKHLDDLYHEQCDSVCILFASIPNFSEFYVELEGNNEGVECLRLLNEIIADF 1330
            ||.|:.:.:| |..||  :||.|....|.::||.:.||     |::     :..||:||||||:|
  Fly   834 LPSHIVDVYLNSLAKH--ELYFENYRMVSVMFAMLINF-----EMD-----LRSLRVLNEIIAEF 886

  Fly  1331 DE-LLSEERFRCIEKIKSTGATYMAASGLTANTCD---------------------RVNFSH--- 1370
            |. ||..:.:..:||||..|.|||||.||..|...                     |:.|..
  Fly   887 DTLLLFYKEYYTVEKIKIVGCTYMAACGLDLNFAGSTSTNRKESIPPTEFNEEQSRRILFQQSNE 951

  Fly  1371 -----VTAMADYALQLFDKIEEVNM--------HSFNNFRMRIGINIGPVVAGVIGACKPQYDIW 1422
                 |..|..|||.:...:.:.|.        .:..:..:.|||:.|.|:||::||.:|.||||
  Fly   952 DLDEVVFVMTSYALDMMRTLAKSNEAYQSIAGDRNITDGTIAIGISSGEVMAGIVGASQPHYDIW 1016

  Fly  1423 GNAVNVASRMDSTGLVDHIQVTQEMQQILEGRGFELTCRGSVDVKGKGSMITYFL 1477
            ||.||:||||:||||..||.||:|..:||:..|...:.||...|||:|.:.||.:
  Fly  1017 GNPVNMASRMESTGLPGHIHVTEETSEILQQFGITCSYRGMTFVKGRGKIPTYLV 1071

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:292831	44/223 (20%)
		CYCc	686..881	CDD:214485	88/204 (43%)
		Guanylate_cyc	722..895	CDD:278633	81/174 (47%)
		DUF1053	<949..1005	CDD:283888	13/55 (24%)
		CYCc	1259..1455	CDD:214485	85/234 (36%)
		Guanylate_cyc	1285..1479	CDD:278633	84/231 (36%)
ACXE	NP_652601.3	AC_N	<31..272	CDD:318454	45/223 (20%)
		Nucleotidyl_cyc_III	290..459	CDD:325147	80/168 (48%)
		Nucleotidyl_cyc_III	851..1071	CDD:325147	84/229 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453943
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D57794at33392
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850