DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43373 and NPR1

DIOPT Version :9

Sequence 1:	NP_001097622.2	Gene:	CG43373 / 39835	FlyBaseID:	FBgn0263131	Length:	1854	Species:	Drosophila melanogaster
Sequence 2:	NP_000897.3	Gene:	NPR1 / 4881	HGNCID:	7943	Length:	1061	Species:	Homo sapiens

Alignment Length:	1169	Identity:	259/1169 - (22%)
Similarity:	408/1169 - (34%)	Gaps:	370/1169 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   489 VLNTSSNA-GVATDNSDPPLGYGQLIPLILMQVDESVLVFLIVMLICGIVYAFL----------- 541
            ||.:|.|| ||.:|.:.|       :..:.::.:.:..|||..    |.|||..
Human    81 VLGSSENALGVCSDTAAP-------LAAVDLKWEHNPAVFLGP----GCVYAAAPVGRFTAHWRV 134

  Fly   542 -LCILSKPAM-----NEIFLVL---VSYVILGTFLAI---------EVAVSYAMQPSKSFNGSAC 588
             |.....||:     :|..|..   .||..||.|:|.         :..:.||.:|....:
Human   135 PLLTAGAPALGFGVKDEYALTTRAGPSYAKLGDFVAALHRRLGWERQALMLYAYRPGDEEH---- 195

  Fly   589 CIVLIYMTYTMLPLRLREALIGGILLSVVHL---------YT-CLRLNAMQDEAVEMIHWEELLC 643
            |..|:...:    :|:|:.|    .::|.||         || .||....:...:.:....:...
Human   196 CFFLVEGLF----MRVRDRL----NITVDHLEFAEDDLSHYTRLLRTMPRKGRVIYICSSPDAFR 252

  Fly   644 TLVALLL-ANLTG---VYTH-------------------WPKEKAQRKAFIETRQCIE-ARLRTQ 684
            ||:.|.| |.|.|   |:.|                   |.:...|.   :..||..: |::.|.
Human   253 TLMLLALEAGLCGEDYVFFHLDIFGQSLQGGQGPAPRRPWERGDGQD---VSARQAFQAAKIITY 314

  Fly   685 RENQQQERLLLSVLPRHVAME-----MKDDIAGQ-PRDTQFHK---IYIQ------RH------- 727
            ::....|.|......:|:|.|     |:|.:... |  ..||.   :|||      .|
Human   315 KDPDNPEYLEFLKQLKHLAYEQFNFTMEDGLVNTIP--ASFHDGLLLYIQAVTETLAHGGTVTDG 377

  Fly   728 ENV-----SILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKL----LGDCYY 783
            ||:     :..|..:.|:..:......|       ..|:.:| :..|:...|:.|    ......
Human   378 ENITQRMWNRSFQGVTGYLKIDSSGDRE-------TDFSLWD-MDPENGAFRVVLNYNGTSQELV 434

  Fly   784 CVSG------LPEPRPDHAHCAVEM--------GLDMIDAIALVRE-----VMAVNVNMRVGIHT 829
            .|||      |..|.||...|..:.        .|..::.:|||..     ::.|:..:...:..
Human   435 AVSGRKLNWPLGYPPPDIPKCGFDNEDPACNQDHLSTLEVLALVGSLSLLGILIVSFFIYRKMQL 499

  Fly   830 GRVHCGVLGLVKWQFDVWSNDVTLANHMESGGIPGRVHITKETLKCLDGDYEVEVGKGNERNSYL 894
            .:.....|..|:|: ||  ...:|..|:.|.|       ::.||.          |:|:...|.|
Human   500 EKELASELWRVRWE-DV--EPSSLERHLRSAG-------SRLTLS----------GRGSNYGSLL 544

  Fly   895 -KDHQIETY---LIVPGDIYRPHKKSRNRLQVNGNISKELRMMGHGTAQKHTSKFGFGDSSESAK 955
             .:.|.:.:   ....|::....:.:|.|:::...:..||:.|
Human   545 TTEGQFQVFAKTAYYKGNLVAVKRVNRKRIELTRKVLFELKHM---------------------- 587

  Fly   956 DPEDEVNEYLMRAIDARSIDHLRAEHCQSLLLCFKDNVLERKYASEPDRMLCVYFYC---SLL-V 1016
              .|..||:|.|.:.|                           .::|..:..:..||   ||. :
Human   588 --RDVQNEHLTRFVGA---------------------------CTDPPNICILTEYCPRGSLQDI 623

  Fly  1017 LLGTSIMRLVVFQSSLLT------LALSTGALLLLGFLVFLVACHKINFQLPSDIKRFSLRIHSN 1075
            |...||....:|:.||..      |.|..||:           |.                 |.|
Human   624 LENESITLDWMFRYSLTNDIVKGMLFLHNGAI-----------CS-----------------HGN 660

  Fly  1076 RRISQLFAFASVALIVLTTLLAMFQE-SGRQMELLQRRRFWL----------DVNGS-------- 1121
            .:.|.........|.:....|..|:: ...|...:..::.|.          .|.||
Human   661 LKSSNCVVDGRFVLKITDYGLESFRDLDPEQGHTVYAKKLWTAPELLRMASPPVRGSQAGDVYSF 725

  Fly  1122 ------------------ISLNDTELNTKMYDAEEPDCDFYLAYNTFLLLTLLSMMSC------- 1161
                              :.|:..|:..::...|:|.....||..:.|....|.|..|
Human   726 GIILQEIALRSGVFHVEGLDLSPKEIIERVTRGEQPPFRPSLALQSHLEELGLLMQRCWAEDPQE 790

  Fly  1162 -ATYQVLRILLKLLLLLLASGSYMACSSNLYSRSREMSQELANEEALLRYIIDSIFLFAFMLALI 1225
             ..:|.:|:.|:......:|.    ...||.||   |.|...|.|.|:
Human   791 RPPFQQIRLTLRKFNRENSSN----ILDNLLSR---MEQYANNLEELV----------------- 831

  Fly  1226 FHSHQTEATYRLDFIWKLQATEEKEDMEHLQAYNRKLLENILPVHVAEHFLSREKHLDDLYHEQC 1290
              ..:|:|           ..|||...|       .||..|||..|||..    |..:.:..|..
Human   832 --EERTQA-----------YLEEKRKAE-------ALLYQILPHSVAEQL----KRGETVQAEAF 872

  Fly  1291 DSVCILFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDELLSEERFRCIEKIKSTGATYMAA 1355
            |||.|.|:.|..|:    .|...:..::.:.|||::...||.::  :.|. :.|:::.|..||..
Human   873 DSVTIYFSDIVGFT----ALSAESTPMQVVTLLNDLYTCFDAVI--DNFD-VYKVETIGDAYMVV 930

  Fly  1356 SGLTANTCDRVNFSHVTAMADYALQLFDKIE--EVNMHSFNNFRMRIGINIGPVVAGVIGACKPQ 1418
            |||..    |....|...:|..||.|.|.:.  .:........|:||||:.|||.|||:|...|:
Human   931 SGLPV----RNGRLHACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPR 991

  Fly  1419 YDIWGNAVNVASRMDSTGLVDHIQVTQEMQQILEG-RGFELTCRGSVDVKGKGSMITYFLKGRR 1481
            |.::|:.||.||||:|.|....|.::.|.:.:||. .||||..||.|::||||.:.||:|.|.|
Human   992 YCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFGGFELELRGDVEMKGKGKVRTYWLLGER 1055

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:292831	56/265 (21%)
		CYCc	686..881	CDD:214485	48/244 (20%)
		Guanylate_cyc	722..895	CDD:278633	42/214 (20%)
		DUF1053	<949..1005	CDD:283888	7/55 (13%)
		CYCc	1259..1455	CDD:214485	65/198 (33%)
		Guanylate_cyc	1285..1479	CDD:278633	70/196 (36%)
NPR1	NP_000897.3	PBP1_NPR_A	36..443	CDD:107380	84/397 (21%)
		ANF_receptor	54..414	CDD:279440	78/368 (21%)
		PK_GC-A_B	534..807	CDD:270944	57/361 (16%)
		TyrKc	547..801	CDD:197581	52/332 (16%)
		HNOBA	<816..861	CDD:285003	22/84 (26%)
		CYCc	840..1032	CDD:214485	71/213 (33%)
		Guanylate_cyc	867..1053	CDD:278633	70/196 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810