Protein Alignment CG43373 and Ac3

DIOPT Version :10

• Sequence 1: NP_001097622.2
• Gene: CG43373 / 39835
• FlyBaseID: FBgn0263131
• Length: 1854
• Species: Drosophila melanogaster
• Sequence 2: XP_061511365.1
• Gene: Ac3 / 4578014
• VectorBaseID: AGAMI1_012876
• Length: 1207
• Species: Anopheles gambiae
• Alignment Length: 1315
• Identity: 416/1315 - (31%)
• Similarity: 639/1315 - (48%)
• Gaps: 246/1315 - (18%)

  Fly   522 ESVL---VFLIVMLICGIVYAFLLC-------ILSKPAMNEIFLVLVSYVILGTFLAIEVAVSYA 576
            ||::   |||.:.::..||..|  |       ::.:.|.:..:|:.:..:.|..||...|.
Mosquito    66 ESIVVTSVFLTINIVLAIVLRF--CGRGRFRGVIWEIAPHLAWLLAIKQLFLQLFLKGSVT---- 124

  Fly   577 MQPSKSFNGSACCIVLIYMTYTMLPLRLREALIGGILLSVVHLYTCLRLNAMQDEA-VEMIHWEE 640
              |..|...:   ::|.::.|..||:.|:..   ||||.:....|  .:||:...| .|...||:
Mosquito   125 --PRDSLGWA---VLLNFLVYVTLPVLLKYT---GILLGLGSFAT--YVNAIIGLAKKENYFWEQ 179

  Fly   641 LLCTLVALLLANLTGVYTHWPKEKAQRKAFIETRQCIEARLRTQRENQQQERLLLSVLPRHVAME 705
            .:..::.|:.|.|.|:..::..|..||:||:|.:|.:|.::..:.::.:||||||||||.|||::
Mosquito   180 QVANILLLIAATLIGLLCYFLAEAKQRRAFLEAKQGLEVKMLIEEQSAEQERLLLSVLPEHVAVK 244

  Fly   706 MKDDIAGQPRDTQFHKIYIQRHENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEH 770
            |:.|: |.....||.|||:.||||||||:|||.|||::|...:|::||::||||||||||||.::
Mosquito   245 MRQDL-GSTNSEQFKKIYMSRHENVSILYADIVGFTAISSTYSAQDLVKILNELFARFDRLAEKY 308

  Fly   771 HCLRIKLLGDCYYCVSGLPEPRPDHAHCAVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCG 835
            ..||||:|||||||:||.|..|||||...|.|||.|:.||..|::.....|:||||||||.|..|
Mosquito   309 QQLRIKILGDCYYCISGAPVERPDHAVLCVHMGLSMVKAIKYVQQKTNSPVDMRVGIHTGAVLAG 373

  Fly   836 VLGLVKWQFDVWSNDVTLANHMESGGIPGRVHITKETLKCLDGDYEVEVGKGNERNSYLKDHQIE 900
            :||..:|||||:|.||.|||.|||.|..||||::::||..|:|::|||...|.:|...|:...::
Mosquito   374 ILGQRQWQFDVYSKDVELANKMESSGKAGRVHLSEKTLGFLNGEFEVEPAFGEKREEALRIAGLK 438

  Fly   901 TYLIVPGDIYRPHKKSRNRLQVNGNI------------SKELRMMGHGT-------AQKHTSKFG 946
            ||.|.  .:.:|...|.::   ||:.            |:.||.....|       |....|..|
Mosquito   439 TYFIT--KVLKPFCPSEHK---NGSADPKDVVIEPDGPSEILREDDDDTKPANGANAGDEPSTPG 498

  Fly   947 FGDSSESAKDPEDEVNEYLMRAIDARSIDHLRAE------HCQ-----SLLLCFKDNVLERKYAS 1000
            ..|.::..:|......:|.||         ||.|      |.:     ::.|.|.|...|..|..
Mosquito   499 TDDKTDPLEDDTQASEDYKMR---------LRKELVSRDGHSEISKDTTIFLTFNDKTHETAYNE 554

  Fly  1001 EPDRMLCVYFYCSLLVLLGTSIMRLVVFQSSLLTLALSTGALLLLGFLVFLVACHKINFQLPSDI 1065
            ..:....|....:|||.....:..|:|...:.:...:....|:::..:||:.....:...||:.|
Mosquito   555 YREPHSAVPLLAALLVQFVAILYALLVLPRTAVHFEIVIPPLVIIFVMVFISVAESLTGILPAFI 619

  Fly  1066 KRFSLRIHSNRRISQLFAFASVALIVLTTLLAMFQESGRQMELLQRRRFWLDVNGSISLNDTELN 1130
            ...|.|.:.:..:.:..|...|.|:.::.:..|...|.|.               .:|||.|.::
Mosquito   620 TLNSKRYNDSTSLRKSTAIIIVLLLGVSNVSDMLAASHRT---------------PLSLNITNVS 669

  Fly  1131 TKMYDAEEPDCDFYLAYNTFLLLTLLSMMSCATYQVLRILLKLLLLLLASGSYMACSSNLYSRSR 1195
            ....:.|......:.:|  |...|:|.:::.:....|..|.|:||:::.:..:  |..|::
Mosquito   670 FASTEMEPASVCLFPSY--FSNYTVLILIATSIITQLSHLSKILLMIIITAIH--CYVNIF---- 726

  Fly  1196 EMSQELANEE------ALLRYIIDSIFLFAFMLALIFHSHQTEATYRLDFIWKLQATEEKEDMEH 1254
            .:.:...||:      ..|||.: |..|.|..:||.|.:...:...|:.|:||.:..::||....
Mosquito   727 HLDEAFRNEDFGIMNVFPLRYTL-SALLVAVTIALSFLARHIDKVDRVIFMWKTEVIDQKEKASD 790

  Fly  1255 LQAYNRKLLENILPVHVAEHFL-SREKHLDDLYHEQCDSVCILFASIPNFSEFYVELEGNNEGVE 1318
            ::..|..|:.|:||:||||||: :|::..||||.:....|.:||||:||||:||.|...||:|:|
Mosquito   791 MRRRNEALVYNVLPMHVAEHFMGNRKRSHDDLYSQSYAEVGVLFASMPNFSDFYSEETVNNQGLE 855

  Fly  1319 CLRLLNEIIADFDELLSEERFRCIEKIKSTGATYMAASGLTANTCDR------VNFSHVTAMADY 1377
            |||.|||:|:|||.||...:|:.|.|||:.|:||||||||..:...:      |.::|:..:.::
Mosquito   856 CLRFLNEVISDFDALLELPQFQDIIKIKTIGSTYMAASGLNPSRIVKPDDPVSVRWAHLALLVEF 920

  Fly  1378 ALQLFDKIEEVNMHSFNNFRMRIGINIGPVVAGVIGACKPQYDIWGNAVNVASRMDSTGLVDHIQ 1442
            ||:|...::.:|..|||:|.:::|:|.||:.||||||.||.||||||.|||||||:|||....||
Mosquito   921 ALELKKALQGINEQSFNHFVLKMGVNHGPITAGVIGARKPHYDIWGNTVNVASRMESTGKAGAIQ 985

  Fly  1443 VTQEMQQILEGRGFELTCRGSVDVKGKGSMITYFLKGRRPIDAKELELAKTEVEPPKTLTLAKEP 1507
            ||:|..|||:..|:....||.|.|||||.::||:|:|:.|              .|...|.:...
Mosquito   986 VTEETCQILQTFGYTFEQRGLVAVKGKGQLMTYYLQGKVP--------------RPTGPTASPIL 1036

  Fly  1508 EKLDSGTATEKQREQVKEQGSTEQEDDLLPSPDIDMNSNMQNLTAQRRKSLCRQHNISSSFGTTV 1572
            :.|.:       .|.|:|...:::....|..|..|..|....|           |::||.
Mosquito  1037 QNLTA-------METVQEVDESKESPPALAPPPGDGASPAHQL-----------HSVSSP----- 1078

  Fly  1573 SSSTGITPSISNSSSVVTIGALPAILRGGNPLSNANPNATDSCSECGGASKSLATPTAPPRTLVA 1637
                                            |.|:||:..
Mosquito  1079 --------------------------------STASPNSVR------------------------ 1087

  Fly  1638 DLKDEIARDEKIGLKDSIENLEILLKNNISLSDLSNKQQQNLRGETSSSTTTTLRKRDTIVSFNV 1702
                  ...|.:.:|.|..:..:|.:::.|:               |::||||...:.|:||...
Mosquito  1088 ------LNQEYVEMKASNASTAMLQESSSSI---------------SNNTTTTTSTKLTVVSEKT 1131

  Fly  1703 TETVTTTAAPFTSSSGSSNSSSQQKKRRSVTTIAASFTTSTTTRLLSNESQSSTQTAPGTLESGG 1767
            |          |.||.||.||         ||:..|.:.:..:.:.|:...:..:..|.. ||..
Mosquito  1132 T----------TISSTSSTSS---------TTVETSVSKTAQSSVRSSSLFNGGEATPAD-ESDA 1176

  Fly  1768 SVP---GQSSTENSS 1779
            ..|   |::||..||
Mosquito  1177 QTPLLEGKNSTNASS 1191

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:318454	61/207 (29%)
		Guanylate_cyc	722..904	CDD:425528	103/181 (57%)
		Adcy_cons_dom	<949..1005	CDD:461877	14/66 (21%)
		Guanylate_cyc	1285..1479	CDD:425528	102/199 (51%)
Ac3	XP_061511365.1	None