DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43373 and Gycbeta100B

DIOPT Version :9

Sequence 1:	NP_001097622.2	Gene:	CG43373 / 39835	FlyBaseID:	FBgn0263131	Length:	1854	Species:	Drosophila melanogaster
Sequence 2:	NP_524603.2	Gene:	Gycbeta100B / 43682	FlyBaseID:	FBgn0013973	Length:	787	Species:	Drosophila melanogaster

Alignment Length:	783	Identity:	178/783 - (22%)
Similarity:	304/783 - (38%)	Gaps:	185/783 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   749 AEELVRLLNELFARF------DRL----------------AAEHHCLRIKLLGDCYYCVSGLPEP 791
            |::::.|..:.|..|      |::                |...|      ||..|      |..
  Fly    63 ADDILELFGKTFFEFCQDSGYDKILQVLGATPRDFLQNLDALHDH------LGTLY------PGM 115

  Fly   792 RPDHAHCAVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCGVLGLVKWQFDVWSNDVTLANH 856
            |.....|..:.|           |::....:.|.|:.    |. |:|:||          .:|:.
  Fly   116 RAPSFRCTEKDG-----------ELLLHYYSERPGLE----HI-VIGIVK----------AVASK 154

  Fly   857 MESGGIPGRVHITKETLKCLDGDYEVEVGKGNERNSYLKDHQIETYLIVPGDIYRPHKKSRNRLQ 921
            :.  |:...:.|.|...:.:| :.|.|.....|....|:|....|.......:..|...:.....
  Fly   155 LH--GVEVEIDIVKRKGEPID-EAEKERAIARENQQLLEDAVATTTTGSATVVLAPSSDAERNNN 216

  Fly   922 VNG-NISKELRMMGHG-TAQKHTSKFGFGDSSES-----------AKDPED---EVNEYLMRAID 970
            .|| |.|....|..:| |...:.:..|...:||:           |:|..|   :..:..:|.:.
  Fly   217 HNGSNGSNNNGMANNGNTVNVNNNNDGQQIASETDPSIALSTCPIAQDSFDCDGDKEQKCLRLLK 281

  Fly   971 ARSIDHLRAEHCQSLL----LCFKDNVLERKYASEPDRMLCVYFYCSLLVLLGTSIMRLVVFQSS 1031
            .:|.|..|.:|.|.|:    :..|..| :.|....||.|   .|.|                ::.
  Fly   282 NKSDDIERYDHVQFLIREINVAAKSQV-DAKKDEVPDDM---EFLC----------------EAP 326

  Fly  1032 LLTLALSTGALLLLGFLVFLVACHKINFQLPSDIKRFSLRIHSNRRISQLFAFASVALIVLTTLL 1096
            |::.|               ..|....|.|..|  |....:.:.:.:|::             :.
  Fly   327 LISPA---------------TFCKVFPFHLMFD--RQMKIVQAGKAVSRV-------------IP 361

  Fly  1097 AMFQESGRQMELLQRRRFWLDVNGSISLNDTELNTKMYDAEEPDCDFYLAYNTFLLLTLLSMMSC 1161
            .:.:|:...:|:::..|..|.:|....|  :.:||                 .::|.|....||.
  Fly   362 RVAEENCSLIEVVEAIRPHLQLNFENIL--SHINT-----------------IYVLQTRQGAMSS 407

  Fly  1162 ATYQ-VLRILLKLLLLLLASGSYMACSSNLYSRSREMSQELANEEALLRYIIDSIFLFAFMLALI 1225
            ...| .||:..:::.:.........|..::      |:.:...::.|  ||.| :.|......|:
  Fly   408 RHEQRFLRLKGQMMYIPETDRILFQCYPSV------MNLDDLTKKGL--YISD-VPLHDAARDLV 463

  Fly  1226 FHSHQTEATYRLD-----FIWKLQATEEKEDMEHLQAYNRKLLENILPVHVAEHFLSREKHLDDL 1285
            ..|.:.||.|:|.     ...|||.|  ..|:|..:....:||.::||..||...    :|...:
  Fly   464 LLSEKFEAEYKLTKNLEMLTDKLQQT--FRDLESEKQKTDRLLYSVLPKSVANEL----RHQRPV 522

  Fly  1286 YHEQCDSVCILFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDELLSEERFRCIEKIKSTGA 1350
            ..::.|||.::|:.|..|.::.......:..::.:::|||:...||.|...:|...:.|:::.|.
  Fly   523 PPKRYDSVTLMFSGIVGFGQYCAANTDPDGAMKIVKMLNELYTVFDALTDSKRNLNVYKVETVGD 587

  Fly  1351 TYMAASGLTANTCDRVNFSHVTAMADYALQLFDKIEEVNMHSFNNFRMRIGINIGPVVAGVIGAC 1415
            .|||.||| .:.|:    .|...||..||.:.|..:.|.|.| |..::.|||:.|.||.||||..
  Fly   588 KYMAVSGL-PDHCE----DHAKCMARVALDMMDMAKNVKMGS-NPVQITIGIHSGEVVTGVIGNR 646

  Fly  1416 KPQYDIWGNAVNVASRMDSTGLVDHIQVTQEMQQIL-----EGRGFELTCRGSVDVKGKGS-MIT 1474
            .|:|.::||.||:.||.::||:...|.|::|..::|     :...|.|..||.|.:|||.: |..
  Fly   647 VPRYCLFGNTVNLTSRTETTGVPGRINVSEETYRLLCMAINQDDSFHLEYRGPVIMKGKPTPMDC 711

  Fly  1475 YFL 1477
            :||
  Fly   712 WFL 714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:292831
		CYCc	686..881	CDD:214485	27/153 (18%)
		Guanylate_cyc	722..895	CDD:278633	30/167 (18%)
		DUF1053	<949..1005	CDD:283888	17/73 (23%)
		CYCc	1259..1455	CDD:214485	63/200 (32%)
		Guanylate_cyc	1285..1479	CDD:278633	67/199 (34%)
Gycbeta100B	NP_524603.2	HNOB	2..164	CDD:285002	24/140 (17%)
		HNOBA	326..516	CDD:285003	48/249 (19%)
		CYCc	496..688	CDD:214485	63/201 (31%)
		Guanylate_cyc	522..714	CDD:278633	65/197 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453939
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740