DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43373 and Gyc88E

DIOPT Version :9

Sequence 1:	NP_001097622.2	Gene:	CG43373 / 39835	FlyBaseID:	FBgn0263131	Length:	1854	Species:	Drosophila melanogaster
Sequence 2:	NP_001036711.1	Gene:	Gyc88E / 41825	FlyBaseID:	FBgn0038295	Length:	1097	Species:	Drosophila melanogaster

Alignment Length:	927	Identity:	202/927 - (21%)
Similarity:	348/927 - (37%)	Gaps:	242/927 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly  1057 INFQLPSDIKRFSL------RIHSNRRIS-----QLFAFASV-------------ALIVLTTLLA 1097
            :.|||..|.:.|:|      |...:..||     ::|.|..|             .:::|..||
  Fly   176 VTFQLTFDNRAFTLASLAMTREEKHLPISAHVLFEIFPFCMVFGADMVVRSIGNSLMVILPELL- 239

  Fly  1098 MFQESGRQMELLQRRRFWLDV----------------NGSISLNDTELNTKMYDAE--------- 1137
                 |:::..      |.|:                |....|...:..|:.:|.:
  Fly   240 -----GKKITA------WFDLVRPLIAFKFQTILNRTNNIFELVTVDPVTERFDVQNEDLLQHED 293

  Fly  1138 --EPDCDFYLAYNTFLLLTLLSMMSCATYQVLRIL----LKLLLLLLASGSYMACSSNLYSRSRE 1196
              ||:....|..         .|:....::::..|    :..|..|:.:|.|:. ..:::..||:
  Fly   294 GSEPEKSLRLKG---------QMVYMENWRMIMFLGTPVMPDLTSLITTGLYIN-DLSMHDFSRD 348

  Fly  1197 MSQELANEEALLRYIIDSIFLFAFMLALIFHSHQTEATYRLDFIWKLQATEEKEDMEHLQAYNR- 1260
            :                       |||      .|:.:..|    ||...:|::..:.|:...|
  Fly   349 L-----------------------MLA------GTQQSVEL----KLALDQEQQKSKKLEESMRL 380

  Fly  1261 ---------KLLENILPVHVAEHFLSREKHLDDLYHEQCDSVCILFASIPNFSEFYVELEGNNEG 1316
                     :||..::|..||:.....|..:|..  |..|||.|||:.|..|:|....:    ..
  Fly   381 LDEEMRRTDELLYQMIPKQVADRLRRGENPIDTC--EMFDSVSILFSDIVTFTEICSRI----TP 439

  Fly  1317 VECLRLLNEIIADFDELLSEERFRCIEKIKSTGATYMAASGL---TANTCDRVNFSHVTAMADYA 1378
            :|.:.:||.:.:.||:|  .|| ..:.|:::.|..||..:|.   .||..:||        .|.|
  Fly   440 MEVVSMLNAMYSIFDKL--TER-NSVYKVETIGDAYMVVAGAPDKDANHAERV--------CDMA 493

  Fly  1379 LQLFDKIEEVNMHSF-NNFRMRIGINIGPVVAGVIGACKPQYDIWGNAVNVASRMDSTGLVDHIQ 1442
            |.:.|.|.::...|. .:.|:|:|::.|.||||::|...|:|.::|:.||.||||:||.:...:.
  Fly   494 LDMVDAITDLKDPSTGQHLRIRVGVHSGAVVAGIVGLKMPRYCLFGDTVNTASRMESTSIAMKVH 558

  Fly  1443 VTQEMQQILEGRGFELTCRGSVDVKGKGSMITYFLKGRRPIDAKELEL-AKTEVEP--------- 1497
            :: |..::|.|..:::..||.:||||||:|.||:|:.|.  :...|:| |..:|.|
  Fly   559 IS-ESTKVLIGPNYKIIERGEIDVKGKGTMGTYWLEERE--NRLPLQLTAALQVHPLSPVPPTPT 620

  Fly  1498 PKTLTLAKEPEKLDSGTATEKQREQVKEQGSTEQEDDLLPSPDIDMNSNMQN---LTAQRRKSLC 1559
            |||..:.....|    ..|......|....|....:  :|:.|:..:|:..:   |||.....:.
  Fly   621 PKTKAIMPPVSK----PLTPMMPVSVSLAASMPTSN--VPAVDVMASSSSISGLALTAAAAAHMS 679

  Fly  1560 RQHNISSSFGTTVSSSTGITPSISNSSSVVTIGALPAILRGGNPLSNANPNATDSCSECGGASKS 1624
            ..|....:...|.:|.....||:::       ||..|...||.|..:.|.......:....|.:|
  Fly   680 LHHQAVVAEALTGASVEVALPSVAS-------GATGAAAGGGAPSDDRNSRIYSPVTFKDVARRS 737

  Fly  1625 LATPTAPPRTLVADLKDEIARDEKIG-----------------LKDSIENLEILLKNNISLSDLS 1672
            :|  .:|.|: .|....|..|:.:..                 :.|:.|.||.|   .||.|.|:
  Fly   738 VA--NSPVRS-CAQPDQERRRESRSNSTGHVFMRTPSEIFGSLILDTEEFLEDL---QISRSSLA 796

  Fly  1673 NKQQQNLRGETSSSTTTTLR-----------------KRDTIVSFNVTETVTTTAAPFTSSSGSS 1720
            |  ..|.:.....|.|...|                 ..:......:|...|..|....|.|.:|
  Fly   797 N--NNNNQSPCGFSPTPPFRIGSAPPKPRPSNPDKFTPEELAAMDQLTPPSTAPARETASCSSAS 859

  Fly  1721 NSSSQQKKRRSVT-TIAASFTTSTTTRLLSNESQSSTQTAP------------GTLESGGSVPGQ 1772
            ....:..|.:.:| :.::|...:|.|.|.:......|::.|            .|.:..|..||.
  Fly   860 LDRDKATKLKKITFSNSSSLDATTPTALAAVVCPMRTKSPPMAVAPVMHMVQASTSKGDGQRPGS 924

  Fly  1773 SSTENS------------SQDWQPRTASLEPNRS--PIKTSQSMSPIGQLTTEVFVLPNSRSMVL 1823
            ..:.:|            |...:|.:.|....::  ..|.:::|..:.::..||   ....|..:
  Fly   925 KDSVSSISLHSPPPHRSNSAPARPHSMSKAARKAFLAAKQTKAMEKLDKMIEEV---QEVESQSV 986

  Fly  1824 ISSTNGSVSALATGGGG 1840
            ..:.|..::.....|||
  Fly   987 AKAANMRLALYGHDGGG 1003

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:292831
		CYCc	686..881	CDD:214485
		Guanylate_cyc	722..895	CDD:278633
		DUF1053	<949..1005	CDD:283888
		CYCc	1259..1455	CDD:214485	64/209 (31%)
		Guanylate_cyc	1285..1479	CDD:278633	68/197 (35%)
Gyc88E	NP_001036711.1	HNOB	2..164	CDD:311572
		HNOBA	201..404	CDD:311573	41/257 (16%)
		CYCc	383..571	CDD:214485	63/205 (31%)
		Herpes_ICP4_C	794..>955	CDD:332854	28/162 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453950
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740