Protein Alignment CG43373 and Ac76E

DIOPT Version :9

• Sequence 1: NP_001097622.2
• Gene: CG43373 / 39835
• FlyBaseID: FBgn0263131
• Length: 1854
• Species: Drosophila melanogaster
• Sequence 2: NP_001246838.1
• Gene: Ac76E / 40180
• FlyBaseID: FBgn0004852
• Length: 1312
• Species: Drosophila melanogaster
• Alignment Length: 1462
• Identity: 419/1462 - (28%)
• Similarity: 629/1462 - (43%)
• Gaps: 449/1462 - (30%)

  Fly   315 ATVGNLTTATMKPPTLASSDQMTRGSSIPLLALASNGSWAGNGAVGGELKSAHNHNIADFEADHN 379
            |..||.|.||..  .:..:|    |::....|:.|:.:         .:..|.:.::||.....|
  Fly     9 AKTGNGTNATAN--LIVKAD----GNATQPKAMTSSAA---------RMNDALSASLADLSEQEN 58

  Fly   380 GQLVWRRQKRKHYRRLHKHRYKHKSHQQHRTRYRMREKRSLQDAGLVKGGGIQTQLIVDTATDDD 444
            |...    :..|...|:             ||||.|.::||..:||:      |.|:
  Fly    59 GTTA----EDIHLNDLY-------------TRYRQRLRKSLFRSGLL------TSLL-------- 92

  Fly   445 ADVYTVASDDDDDVDGGRSAGSKHITYTPRVRDYNQISHAERDEVLNTSSNAGVATDNSDPPLGY 509
            |.|.::.                                            .|:.         |
  Fly    93 ACVVSII--------------------------------------------IGIV---------Y 104

  Fly   510 GQ-LIPLILMQVDESVLVFLIVMLICGIVYAFLL--CILSKPAMNEIFLVLVSYVILGTFLAI-- 569
            || |:..:|:         ::..||.|.:...|.  .:||.||....|.::.:: .|||..||
  Fly   105 GQHLVQTMLL---------VLAALISGSILTALQFPAVLSSPAAALAFAIVTTF-SLGTIAAITG 159

  Fly   570 -EVA--VSYAMQPSKSFNGSACCIVLIYMTYTMLPLRLREALIGGILLSVVHLYTCLRLNAMQDE 631
             |:|  ..||:         ..||      ::|||:....:::..:.::.:|:  ..|:....|.
  Fly   160 DELAPLPMYAL---------FLCI------HSMLPISWPVSVVLALFMTAIHI--VYRIGTSPDY 207

  Fly   632 A--VEMIHWEELLCTLVALLLANLTGVYTHWPKEKAQRKAFIETRQCIEARLRTQRENQQQERLL 694
            |  :.|:..|     :|.|..|:::|:|.....:.|..:....||..||.|::.:.|.:|||:||
  Fly   208 APNLPMLFGE-----IVMLASASVSGLYYRIMSDAAHNRTVDGTRTGIEQRVKLECEREQQEQLL 267

  Fly   695 LSVLPRHVAMEMKDDIAGQPRD-------------TQFHKIYIQRHENVSILFADICGFTSLSDQ 746
            |||:|.::|.|:|..|..:..|             |:||::::|||.||:||||||..||.||..
  Fly   268 LSVIPAYIAAEVKRSIMLKMADACQRAGGQASTSATRFHELHVQRHTNVTILFADIVNFTPLSSS 332

  Fly   747 CTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEPRPDHAHCAVEMGLDMIDAIA 811
            .||.:||:.||:||.|||::|.|:.|||||:||||||||||||..||.||...|.|||.|||||.
  Fly   333 LTASDLVKTLNDLFGRFDQIAQENQCLRIKILGDCYYCVSGLPISRPQHATNCVNMGLQMIDAIR 397

  Fly   812 LVREVMAVNVNMRVGIHTGRVHCGVLGLVKWQFDVWSNDVTLANHMESGGIPGRVHITKETLKCL 876
            .|||...:||:||:|||||.|.||||||.||||||||:||||||||||||:.|||||||:||..|
  Fly   398 HVREATGINVDMRIGIHTGNVLCGVLGLRKWQFDVWSDDVTLANHMESGGVAGRVHITKQTLDFL 462

  Fly   877 DGDYEVEVGKGNERNSYLKDHQIETYLIVP----------------------------------- 906
            ...:|||.|:|..|::||.||::|:|||||
  Fly   463 GDKFEVEQGEGGNRDAYLADHKVESYLIVPPKPAYTYSVPRVVECIEQNDPSPTTEETKEIKETD 527

  Fly   907 --------GDIYRP--------------------------------------------------- 912
                    .|:..|
  Fly   528 QSHEATDVADVLLPVTVAPPPAIVDEKMSPTSINSQEAPLHAPLASAASMSIKELSEEEDEADEA 592

  Fly   913 --------HK----KSRNRLQVNG------------NISKE----------LRMMG------HGT 937
                    |:    |:....:.||            :::|.          |.|.|      :..
  Fly   593 TAVTEPLMHRDQDGKNDKEPKANGGHRGSGDSAASESVAKSAALSLPADDLLSMSGSESGISNSG 657

  Fly   938 AQKHTSK--------------------------------------FGFGD--------------- 949
            ||..:|.                                      ..|.|
  Fly   658 AQAQSSNPASVTPTAAAPAGGAASNSLTVAEAPERSRRKLSVQGLMSFADRRRSSGAFIEGRKLS 722

  Fly   950 --SSESAKD---------PEDEVNEY-----------------LMRAIDARSIDHLRAEHCQSLL 986
              |.||.:.         |..::.:|                 |::.|...||..:.:.......
  Fly   723 IHSGESFRSHAGHVTRNRPSSKMTKYVECWGADRPFANIAESKLVKNIGLASIAMIESNLLPPER 787

  Fly   987 LCFKDNVL------------------ERKYASEPDRMLCVYFYCSLLVLLGTSIMRLVVFQSSLL 1033
            .||..|..                  |..|.::||........|:.::.|..::::|:|.:.:|.
  Fly   788 KCFNFNFFGPPTELKPFTMWYRNTPREAMYRAQPDTHFRFDLICAFVLFLSLAVVQLIVIELNLA 852

  Fly  1034 TLALSTGALLLLGFLVFLVACHKINFQLPSDIKRFSLRIHSNRRISQLFAFASVALIVLTTLL-- 1096
            .|     ..||..|:...:..:..|..:| |:...:...:...::.....:..:|:.|:..:|
  Fly   853 LL-----GSLLASFVSLALFLYLSNMSVP-DVHASTTERNGPGQVVASSRYLRLAMFVVVNILIS 911

  Fly  1097 --AMF------------QESGRQMELLQRRRFWLDVNGSISLNDTELNTKMYDAEEPDCDFYLAY 1147
              |:|            :|......:|:.           :.:...:|:.:.|.:..:.|:.:..
  Fly   912 SCAVFSVINYTVPDGVSKEPSSNQTILES-----------NFSSVFVNSTLEDVQLWEIDYAIPI 965

  Fly  1148 -NTFLLLTLLSMMSCATYQVLRILLKLLLLLLASGSYMAC--SSNLYSRSREMSQELANEEALLR 1209
             ..||....:|:.:.:.:.....:|||:.:|:|..:.:..  .|:|:        |:.|:..:..
  Fly   966 APVFLYCCAISLAAISAFLRSGFILKLIAMLVAVIAQVTVLGYSDLF--------EMYNDANITH 1022

  Fly  1210 YIIDSI--FLFAFMLALIFHS--HQTEATYRLDFIWKLQATEEKEDMEHLQAYNRKLLENILPVH 1270
            .:...|  ||...::.|:.|:  .|.|...|.||:||.:...|:|::|.::..|:.|||||||.|
  Fly  1023 GLPLEIKGFLLLLVIILVLHTLDRQGEYVARTDFLWKAKLKVEQEEVETMRGINKILLENILPAH 1087

  Fly  1271 VAEHFLSREKHLDDLYHEQCDSVCILFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDELLS 1335
            ||.|||..|:. .:||||....|.::||||||:.|||.|.:.|.:|:||||||||||.|||:||.
  Fly  1088 VATHFLHLERS-TELYHESYSCVAVMFASIPNYKEFYDETDVNKQGLECLRLLNEIICDFDKLLL 1151

  Fly  1336 EERFRCIEKIKSTGATYMAASGLTANTCD-----------RVNFSHVTAMADYALQLFDKIEEVN 1389
            :.:|..|||||:..:|||.||||.....|           |....:|..:.::|:.|...::.:|
  Fly  1152 KPKFSGIEKIKTIASTYMCASGLRPGKEDGATSRSFADEKRTEEHNVVILVEFAIALMSILDSIN 1216

  Fly  1390 MHSFNNFRMRIGINIGPVVAGVIGACKPQYDIWGNAVNVASRMDSTGLVDHIQVTQEMQQILEGR 1454
            ..||..||:|||:|.|||:||||||.|||||||.|.|||||||||.|::..:|.|:...:||...
  Fly  1217 RESFQRFRLRIGLNHGPVIAGVIGAQKPQYDIWSNTVNVASRMDSCGVMGRLQTTENTAKILMTA 1281

  Fly  1455 GFELTCRGSVDVKGKGSMITYFLKGRRPIDAK 1486
            |:|..|||...|||||:::|||:|  .|.|.|
  Fly  1282 GYECECRGLTYVKGKGNLVTYFVK--TPFDGK 1311

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:292831	56/218 (26%)
		CYCc	686..881	CDD:214485	125/207 (60%)
		Guanylate_cyc	722..895	CDD:278633	114/172 (66%)
		DUF1053	<949..1005	CDD:283888	17/116 (15%)
		CYCc	1259..1455	CDD:214485	105/206 (51%)
		Guanylate_cyc	1285..1479	CDD:278633	103/204 (50%)
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	74/333 (22%)
		CYCc	259..467	CDD:214485	125/207 (60%)
		Guanylate_cyc	311..469	CDD:278633	108/157 (69%)
		BASP1	510..667	CDD:283191	13/156 (8%)
		CYCc	1079..1283	CDD:214485	104/204 (51%)
		Guanylate_cyc	1101..1305	CDD:278633	103/203 (51%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453954
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D57794at33392
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	1	1.100	-	-	P	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.750