DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43373 and CG10738

DIOPT Version :9

Sequence 1:	NP_001097622.2	Gene:	CG43373 / 39835	FlyBaseID:	FBgn0263131	Length:	1854	Species:	Drosophila melanogaster
Sequence 2:	NP_729905.2	Gene:	CG10738 / 39516	FlyBaseID:	FBgn0036368	Length:	1250	Species:	Drosophila melanogaster

Alignment Length:	781	Identity:	171/781 - (21%)
Similarity:	301/781 - (38%)	Gaps:	197/781 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   382 LVWRRQKRKHYRRLHKHRYKHKSHQQHRTRYRMRE-KRSLQDAG---LVKGGGIQTQLIVDTATD 442
            |:|:..    :|.:..|..:.:...|.:||:.:.. .|.|....   |::...      |..:::
  Fly   526 LLWKID----FREVQIHENEREQQSQKQTRHLLNHLPRRLPPQSTHPLIRTSQ------VSLSSN 580

  Fly   443 DDAD-----VYTVASDDDDDVDGGRSAGSKHITYTPRV-RDYNQISHAERDEVLNTSSNAGVATD 501
            .|||     ::|........:...:....|.:..|..: ::...:..|..|   |..:..|..|
  Fly   581 PDADFRYTTIFTPIGLYKGQLYAIKKVRKKSVDITREMKKELKLLRDARHD---NICAFIGACT- 641

  Fly   502 NSDPP--------LGYGQLIPLIL---MQVDESVLVFLIVMLICGIVYAF--------LLCILSK 547
              |||        ...|.|..::.   :::|...:..::..:|.|::|..        .||..:.
  Fly   642 --DPPNICIISEYCTRGSLKDILENEDVKLDNMFIASMVADIIRGVIYLHDSPIRFHGALCTSNC 704

  Fly   548 PAMNEIFLVLVSYVILGTFLAIEVAVSYAMQPSKSFNGSACCIVLIYMTYTMLPLRLREALIG-- 610
            ...:...:.|..:.:......||.: |..||     :.||.|:.|:|....:|.......::|
  Fly   705 LVDSRWVVKLTDFGLFAFKQGIEDS-STDMQ-----HMSAKCLKLLYRAPELLRQGPSSLVMGTQ 763

  Fly   611 -------GILLSVVHL------------YTCLR--------LNAMQDEAVEMIHWEELLCTLVAL 648
                   ||||..:|:            ..||:        ||..:.....:    |.....|:.
  Fly   764 RGDAYSFGILLYEMHVRRGPFGETGLTPMQCLQKVLQPQDYLNPYRPSLQPL----ETAFDCVSE 824

  Fly   649 LLANLTGVYTHWPKEKAQRKAFIETRQCIEARLR------------------------------- 682
            .|...      |.:....|..|    :.|..:||
  Fly   825 CLREC------WAERPEDRPDF----KTIRTKLRPLRKGMRPNIFDNMMAMMEKYANNLEALVDD 879

  Fly   683 ----TQRENQQQERLLLSVLPRHVAMEMKDDIAGQPRDTQFHKIYIQRHENVSILFADICGFTSL 743
                .|.|.::.:.||..:|||.||.::|          :.||:..:.:|.|||.|:||.|||::
  Fly   880 RTDQLQEEKKKTDALLHEMLPRCVADQLK----------KGHKVDPEHYEQVSIYFSDIVGFTAM 934

  Fly   744 SDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEPRPD-HAHCAVEMGLDMI 807
            |.:||..::|..||:|:..||.:...:...:::.:||.|..|||||....| ||.....|.|.::
  Fly   935 SAECTPLQVVDFLNDLYTCFDSIIGHYDVYKVETIGDAYMVVSGLPLRNGDLHAAEIATMSLHLL 999

  Fly   808 DAIA--LVREVMAVNVNMRVGIHTGRVHCGVLGLVKWQFDVWSNDVTLANHMESGGIPGRVHITK 870
            .|::  .:|......:.:|:|||:|.|..||:||...::.::.:.|..|:.|||.|:|.::|.:.
  Fly  1000 SAVSEFKIRHRPTNRLLLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESSGVPLKIHCSW 1064

  Fly   871 ETLKCLD--GDYEVE-------VGKGNERNSYL--KDHQIETYLIVPGDIYRPHKKSRNRLQVNG 924
            :..:.||  |.|...       .|||::|..:|  :|.:..|            :::..|.|..|
  Fly  1065 QCRQLLDRLGGYHFAERGVISMKGKGDQRTYWLLGEDEEART------------RRTYERSQRRG 1117

  Fly   925 NISKELRMMGHGT---AQKHTSKFGFGDSSESAKDPEDEVNEYLMRAIDARSIDHLR------AE 980
              |:.|.....||   ||:..:::|...|.:....|.:.    |.|:....|...||      .|
  Fly  1118 --SRALNKFIQGTIKQAQEQANEYGIRSSLKQKNLPRNS----LTRSSSLESPKKLRFAAGSLLE 1176

  Fly   981 HCQSLLLCFKDNVLERKYASEPDRMLCVYFYCSLLVLLGTSIMRLVVFQSSLLTLALSTGALLLL 1045
            |              .:|.|: :.:|.|..|..|....|.|....  ::.:.|:|.||..::.::
  Fly  1177 H--------------HRYHSD-EALLEVDSYTGLRRSSGGSTQSR--YEETTLSLTLSCQSIEIV 1224

  Fly  1046 G 1046
            |
  Fly  1225 G 1225

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:292831	46/268 (17%)
		CYCc	686..881	CDD:214485	66/199 (33%)
		Guanylate_cyc	722..895	CDD:278633	61/186 (33%)
		DUF1053	<949..1005	CDD:283888	11/61 (18%)
		CYCc	1259..1455	CDD:214485
		Guanylate_cyc	1285..1479	CDD:278633
CG10738	NP_729905.2	PBP1_Speract_GC_like	41..441	CDD:107365
		ANF_receptor	67..416	CDD:279440
		PK_GC-A_B	570..853	CDD:270944	54/314 (17%)
		TyrKc	597..847	CDD:197581	47/275 (17%)
		HNOBA	<862..907	CDD:285003	9/44 (20%)
		CYCc	886..1078	CDD:214485	67/201 (33%)
		Guanylate_cyc	913..1099	CDD:278633	61/185 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810