Protein Alignment CG43373 and rut

DIOPT Version :9

• Sequence 1: NP_001097622.2
• Gene: CG43373 / 39835
• FlyBaseID: FBgn0263131
• Length: 1854
• Species: Drosophila melanogaster
• Sequence 2: NP_511156.2
• Gene: rut / 32406
• FlyBaseID: FBgn0003301
• Length: 2248
• Species: Drosophila melanogaster
• Alignment Length: 1646
• Identity: 519/1646 - (31%)
• Similarity: 760/1646 - (46%)
• Gaps: 444/1646 - (26%)

  Fly   528 LIVMLICGIV---------YAFLL-----CILSKPAMNEIFLVLVSYVILGTFLAIEVAVSYAMQ 578
            ::|:|.|.::         |..||     |::|.|.:..:|.|....|:.
  Fly    81 VLVLLQCSVIKDHHLPTLCYGILLFTASICVVSMPTLGSVFPVDTKEVMA--------------- 130

  Fly   579 PSKSFNGSACCIVLIYMTYTMLPLRLREALIGGILLSVVHLYTCLRLNAMQDEAVEMIHWEELLC 643
                 .|....:.::::.|.|:||::.||:..||.|..||:  .|.:..:..:|:..:.:.:|:.
  Fly   131 -----EGVWQIVFVVFLAYAMMPLQIWEAVAFGIALPSVHI--SLTVYKIFTDALRYLEYNQLIA 188

  Fly   644 TLVALLLANLTGVYTHWPKEKAQRKAFIETRQCIEARLRTQRENQQQERLLLSVLPRHVAMEMKD 708
            .:|..:..|:.|:..:...|:|||:.|::||.||.:||..|.||::.|||||||||:||||:||:
  Fly   189 NIVIFIGVNVAGLVVNIMMERAQRRTFLDTRNCIASRLEIQDENEKLERLLLSVLPQHVAMQMKN 253

  Fly   709 DIAGQPRDTQFHKIYIQRHENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCL 773
            ||. .|...|||:||||:|||||||||||.|||.||.||:|:||||||||||.|||:||.::|||
  Fly   254 DIL-SPVAGQFHRIYIQKHENVSILFADIVGFTVLSSQCSAQELVRLLNELFGRFDQLAHDNHCL 317

  Fly   774 RIKLLGDCYYCVSGLPEPRPDHAHCAVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCGVLG 838
            |||:|||||||||||||||.|||.||||||||||||||.|.|...|.:|||||||||||.|||||
  Fly   318 RIKILGDCYYCVSGLPEPRKDHAKCAVEMGLDMIDAIATVVEATDVILNMRVGIHTGRVLCGVLG 382

  Fly   839 LVKWQFDVWSNDVTLANHMESGGIPGRVHITKETLKCLDGDYEVEVGKGNERNSYLKDHQIETYL 903
            |.|||||||||||||||||||||.|||||:|:.||..|.|:||||.|.|:||:|||:||.::|:.
  Fly   383 LRKWQFDVWSNDVTLANHMESGGEPGRVHVTRATLDSLSGEYEVEAGHGDERSSYLRDHGVDTFF 447

  Fly   904 IVPGDIYRPHKK---------------SRNRLQV------------------------------- 922
            |||    .||::               ||.:|..
  Fly   448 IVP----PPHRRKPLMLNTLGVRSAIGSRRKLSFRNVSNVVMQLLHTIKFSEPVPFSNIATGSFP 508

  Fly   923 --------------------------------NGNIS-------KELRM------------MGHG 936
                                            :||:.       |.:|:            ||:|
  Fly   509 SAASALGGGVSVGGGGGGGGGGVARGSTCEANSGNVQVSEKGSRKVIRLQKILHATPPPHGMGYG 573

  Fly   937 TA----------------------------------------------QKHTSKFGFGDSSESAK 955
            :.                                              .:|..|.....|..:.|
  Fly   574 SVVGSGGGVDSGISGGGGCVSGGIAGGGGVQVTVGTNPNSTASTISRIHRHNHKNNKSQSKVADK 638

  Fly   956 ---------------DPEDEVNEYLMRAIDARSIDHLRAEHCQSLLLCFKDNVLERKYASEPDRM 1005
                           .|.:.||.:|.:||:|||:|..::||...|.|.|:.:.:||:|..:.|..
  Fly   639 FKRPFRKRHSVAAHHQPTNRVNRFLSQAINARSVDCDKSEHVDRLTLRFRQSDMEREYHKDFDLG 703

  Fly  1006 LCVYFYCSLLVLLGTSIMRLVVFQSSLLTLALSTGALLLLGFLVFLVACHKINFQLPSDIKRFSL 1070
            ......||||:|:..:.:::.....:|:.|.|...|.:.:..::.|:...::.:.:....:.|||
  Fly   704 FTTAMGCSLLLLILGAALQVTALPRTLILLLLFLFAFIWVSAILMLLLAVRLKWIIWDISESFSL 768

  Fly  1071 RIHSNRRISQLFAFASVALIVLTTLLAMFQESGRQMELLQRRRFWLDVNGSISL-NDTELNTKMY 1134
            |:...  |..:....||..:.:.|.::....||               ||:.|. ||:.....:
  Fly   769 RMAIT--IFTVILIYSVGQVNVFTCVSDHPCSG---------------NGTTSFQNDSHRKCSL- 815

  Fly  1135 DAEEPDCDFYLAYNTFLLLTLLSMMSCATYQVLRILLKLLLLL-----------LASGSYMACSS 1188
                |.   |::     |....:.:|.:.:..|.|:.|.||:|           |:..:...|..
  Fly   816 ----PQ---YVS-----LSAAFAFLSVSVFLRLPIIFKSLLVLGMGTIYGLFIELSHQNIFECYD 868

  Fly  1189 NLYSRSREMSQELANEEALLRYIIDSIFLFAFMLALIFHSHQTEATYRLDFIWKLQATEEKEDME 1253
            |..:.|..:            ::|....:..||:|::.|....|.|.||||:|:|||::||::|:
  Fly   869 NRVNASIPL------------HLISLARIAIFMIAILVHGRLVEGTARLDFLWQLQASQEKKEMD 921

  Fly  1254 HLQAYNRKLLENILPVHVAEHFLSRE-KHLDDLYHEQCDSVCILFASIPNFSEFYVELEGNNEGV 1317
            .||..|:::|.|:||.|||.|||..: ::..:|||:....|.::|||:|||:|||.|::|:::|:
  Fly   922 VLQESNKRILHNLLPAHVAAHFLDAQFRNNMELYHQSYAKVGVIFASVPNFNEFYTEMDGSDQGL 986

  Fly  1318 ECLRLLNEIIADFDELLSEERFRCIEKIKSTGATYMAASGL---------TANTCDRVNFSHVTA 1373
            |||||||||||||||||.|:|||.|:|||:.|:||||..||         ..|:..|    |:||
  Fly   987 ECLRLLNEIIADFDELLKEDRFRGIDKIKTVGSTYMAVVGLIPEYKIQPNDPNSVRR----HMTA 1047

  Fly  1374 MADYALQLFDKIEEVNMHSFNNFRMRIGINIGPVVAGVIGACKPQYDIWGNAVNVASRMDSTGLV 1438
            :.:|...:...::|:|.||:|||.:|:||||||||||||||.|||||||||.|||||||||||:.
  Fly  1048 LIEYVKAMRHSLQEINSHSYNNFMLRVGINIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVP 1112

  Fly  1439 DHIQVTQEMQQILEGRGFELTCRGSVDVKGKGSMITYFL--KGRRPIDAK---ELELAKTEVEPP 1498
            .:.|||||:...|.|..||..|||::.|||||.|:||||  .|.:.::.:   .:.|.::...|.
  Fly  1113 GYSQVTQEVVDSLVGSHFEFRCRGTIKVKGKGDMVTYFLCDSGNKSLNGEVRNAMSLPQSLHAPD 1177

  Fly  1499 KTLTLAKEPE-KLDSGTATEK-----------QREQVKEQGSTEQEDDL-LPSPDIDMNSNMQNL 1550
            ..:.:::.|| ::::.|.::|           :.:|:..|...:|.|.| ||:|...::.::...
  Fly  1178 YYMKVSQFPENRVNTDTYSKKENGHLYAGNGVEEQQLLLQHQHKQHDPLPLPAPPPPVHHHLHQQ 1242

  Fly  1551 TAQRRKSLCRQHNISSSFGTTVSSSTGITPSISNSSSVVTIGALPAILRGGN----------PLS 1605
            ..||..|..::..|                       .:..|.||.|...||          ...
  Fly  1243 QQQRLNSKLQKQPI-----------------------FMANGGLPNIRENGNGHNGEHQQQQQQQ 1284

  Fly  1606 NANPNATDSCSECGGASKSLATPTAP----------------------PRTLVADLKDEIARDEK 1648
            ..:........:.||...:..||.|.                      |..:...::.:|....:
  Fly  1285 QQHQQQQQQQQQHGGFMVATTTPPAAVAVPLQPQHHQLQFQHPHQHPLPSAVSVPVQHQILLHHQ 1349

  Fly  1649 IGLK------------DSIEN---------LEILLKNNISLSDLSNKQQQNLRGETSSSTTTTLR 1692
            :.|:            :.|||         :|.|..::.|| |||. ....:......|....:.
  Fly  1350 LQLQHQPVPSVMLREFNIIENPTSGGRHQQMEQLPPHHGSL-DLSG-MGMGVGAGVLGSDCFMMP 1412

  Fly  1693 KRDTIVSF-----------------NVTETVTTTAAPFTS-SSGSSNSSSQQKKRRSVTTIA--- 1736
            :||...::                 |:....:.....||| ..|....|.......||..:|
  Fly  1413 RRDRERTYVPPLNQHGHHPPHHLHSNLNLNQSQHPPSFTSLGYGQCRESEPLLHASSVAPVAKIM 1477

  Fly  1737 ----------ASFTTSTTTRLLSNESQSSTQTAPGTLESGGSVPGQSSTENSSQDWQPRTA---- 1787
                      ..:|:..|  :||.:.|...|.         ....|.....|:||.|...|
  Fly  1478 PMQHAPKYEPPRYTSPHT--MLSQQHQQQQQQ---------QHQHQQPQSQSAQDQQTHPAQDPH 1531

  Fly  1788 ---------SLEPNRSP-----------------IKTSQSMSPIGQLTTEVFVLPNSRSMVLISS 1826
                     |.:|...|                 ::.|:.||....|::.    |:|.||   ||
  Fly  1532 PLQRQYAMYSQQPQLPPKPVLRTYMKPLPKLPTDLEESRDMSSTDDLSSR----PHSPSM---SS 1589

  Fly  1827 TNGSVSAL--ATGGGGASSPR 1845
            ::.|.|..  ..|.|...|||
  Fly  1590 SDESYSKTTEGEGEGDEDSPR 1610

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:292831	63/205 (31%)
		CYCc	686..881	CDD:214485	150/194 (77%)
		Guanylate_cyc	722..895	CDD:278633	137/172 (80%)
		DUF1053	<949..1005	CDD:283888	21/70 (30%)
		CYCc	1259..1455	CDD:214485	114/205 (56%)
		Guanylate_cyc	1285..1479	CDD:278633	118/204 (58%)
rut	NP_511156.2	AC_N	<17..255	CDD:292831	59/195 (30%)
		CYCc	230..425	CDD:214485	150/195 (77%)
		Guanylate_cyc	266..438	CDD:278633	136/171 (80%)
		DUF1053	624..696	CDD:283888	21/71 (30%)
		SLC5-6-like_sbd	<742..>893	CDD:294310	34/192 (18%)
		CYCc	924..1134	CDD:214485	117/213 (55%)
		Guanylate_cyc	954..1151	CDD:278633	116/200 (58%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	131	1.000	Domainoid score	I5105
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	605	1.000	Inparanoid score	I502
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D46761at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	1	1.100	-	-	P	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.870