Protein Alignment CG43373 and Adcy1

DIOPT Version :10

• Sequence 1: NP_001097622.2
• Gene: CG43373 / 39835
• FlyBaseID: FBgn0263131
• Length: 1854
• Species: Drosophila melanogaster
• Sequence 2: NP_001100709.1
• Gene: Adcy1 / 305509
• RGDID: 1309318
• Length: 967
• Species: Rattus norvegicus
• Alignment Length: 947
• Identity: 402/947 - (42%)
• Similarity: 557/947 - (58%)
• Gaps: 112/947 - (11%)

  Fly   590 IVLIYMTYTMLPLRLREALIGGILLSVVHLYTCLRLNAMQDEAVEMIHWEELLCTLVALLLANLT 654
            :::.:::|.:||:|...|:..|::::..||.....|...:...:    |..|....:.....|:.
  Rat    14 LLVTFVSYALLPVRSLLAIGFGLVVAASHLLVTAALVPAKRPRL----WRTLGANALLFFGVNMY 74

  Fly   655 GVYTHWPKEKAQRKAFIETRQCIEARLRTQRENQQQERLLLSVLPRHVAMEMKDDIAGQPRDTQF 719
            ||:.....|::|||||::.|.|||.|||.:.||::|||||:|:|||:||||||:|.. :|.:..|
  Rat    75 GVFVRILTERSQRKAFLQARNCIEDRLRLEDENEKQERLLMSLLPRNVAMEMKEDFL-KPPERIF 138

  Fly   720 HKIYIQRHENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYC 784
            ||||||||:|||||||||.|||.|:.||||:|||:||||||.:||.||.|:||.|||:|||||||
  Rat   139 HKIYIQRHDNVSILFADIVGFTGLASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYC 203

  Fly   785 VSGLPEPRPDHAHCAVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCGVLGLVKWQFDVWSN 849
            ||||.:|:.|||||.|||||||||.|..|.|...|::|||||:|||||.||||||.|||:|||||
  Rat   204 VSGLTQPKTDHAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSN 268

  Fly   850 DVTLANHMESGGIPGRVHITKETLKCLDGDYEVEVGKGNERNSYLKDHQIETYLIVP-------- 906
            ||||||.||:.|:||:|||||.||.||:||||||.|.|:|||::|:.|.|||:.|||
  Rat   269 DVTLANVMEAAGLPGKVHITKTTLACLNGDYEVEPGHGHERNTFLRTHNIETFFIVPSHRRKIFP 333

  Fly   907 ----GDIYRPHKKSRNR---------LQVNGNISKELRMMGHGTAQKHTSKFGFGDSSESAKD-- 956
                .|| :|.|:.:.:         :........|:......|.:....:.....:||..::
  Rat   334 GLILSDI-KPAKRMKFKTVCYLLVQLMHCRKMFKAEIPFSNVMTCEDDDKRRALRTASEKLRNRS 397

  Fly   957 ----------PEDEVNEYLMRAIDARSIDHLRAEHCQSLLLCFKDNVLERKYASEPDRMLCVYFY 1011
                      |...||.|:.|.::||..: |.........|.:|....|:||....|.    ||.
  Rat   398 SFSTNVVYTTPGTRVNRYISRLLEARQTE-LEMADLNFFTLKYKHVEREQKYHQLQDE----YFT 457

  Fly  1012 CS-LLVLLGTSIMRLVVFQSSLLTLALSTGALLLLGF-LVFLVACHKINFQLPSDIKRFSLRIHS 1074
            .: :|.|:..::..|:.    ||.:..|...||||.| :.|||||              :|.:|
  Rat   458 SAVVLALILATLFGLIY----LLVIPQSVAVLLLLVFSICFLVAC--------------TLYLH- 503

  Fly  1075 NRRISQLFAFASVALIVLTTLLAMF-------QESGRQMELLQRRRFWL-DVNGSISLNDTELNT 1131
               |:::..|.....|.:.|.|.:|       ...|..:..|.    |. ..:.:.||.......
  Rat   504 ---ITRVQCFPGCLTIQIRTALCVFIVVLIYSVAQGCVVSCLP----WAWSSHSNSSLVVLAAGG 561

  Fly  1132 KMYDAEEPDCDFYLAYNTFLLLTLLSMMSCATYQVLRILLKLLLL----------LLASGSYMAC 1186
            :........|:   :.:..||..|:..:..|.:..:..|.|::||          |..||.....
  Rat   562 RRTVLPALPCE---SAHHGLLCCLVGTLPLAIFLRVSSLPKMILLSGLTTSYILVLELSGYTKVG 623

  Fly  1187 SSNLYSRSREMSQELANEEALLRYIIDSIFLFAFMLALIFHSHQTEATYRLDFIWKLQATEEKED 1251
            ...|..||.|.              |.:|.||:..|||  |:.|.:...|||::|..||.||::|
  Rat   624 GGALSGRSYEP--------------IMAILLFSCTLAL--HARQVDVRLRLDYLWAAQAEEERDD 672

  Fly  1252 MEHLQAYNRKLLENILPVHVAEHFLSREKHLDDLYHEQCDSVCILFASIPNFSEFYVELEGNNEG 1316
            ||.::..|:::|.|:||.|||:|||.......|||::....|.::|||||||::||:||:|||.|
  Rat   673 MERVKLDNKRILFNLLPAHVAQHFLMSNPRNMDLYYQSYSQVGVMFASIPNFNDFYIELDGNNMG 737

  Fly  1317 VECLRLLNEIIADFDELLSEERFRCIEKIKSTGATYMAASGL--TANTCDRVNF-SHVTAMADYA 1378
            |||||||||||||||||:.::.::.:||||:.|:|||||.||  ||.|..:.:. ||::.:||:|
  Rat   738 VECLRLLNEIIADFDELMDKDFYKDLEKIKTIGSTYMAAVGLAPTAGTRAKKSISSHLSTLADFA 802

  Fly  1379 LQLFDKIEEVNMHSFNNFRMRIGINIGPVVAGVIGACKPQYDIWGNAVNVASRMDSTGLVDHIQV 1443
            :.:||.::|:|..|:|:|.:|:|||:||||||||||.:||||||||.|||||||||||:...|||
  Rat   803 IDMFDVLDEINYQSYNDFVLRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGRIQV 867

  Fly  1444 TQEMQQILEGRGFELTCRGSVDVKGKGSMITYFLKGR 1480
            |:|:.::|....::..|||.|.|||||.|:||||:||
  Rat   868 TEEVHRLLNRCSYQFVCRGKVSVKGKGEMLTYFLEGR 904

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:318454	46/129 (36%)
		Guanylate_cyc	722..904	CDD:425528	132/181 (73%)
		Adcy_cons_dom	<949..1005	CDD:461877	16/67 (24%)
		Guanylate_cyc	1285..1479	CDD:425528	115/196 (59%)
Adcy1	NP_001100709.1	AC_N	<6..139	CDD:318454	46/129 (36%)
		Guanylate_cyc	141..323	CDD:425528	132/181 (73%)
		Guanylate_cyc	706..903	CDD:425528	115/196 (59%)