DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43373 and GUCY2D

DIOPT Version :9

Sequence 1:	NP_001097622.2	Gene:	CG43373 / 39835	FlyBaseID:	FBgn0263131	Length:	1854	Species:	Drosophila melanogaster
Sequence 2:	NP_000171.1	Gene:	GUCY2D / 3000	HGNCID:	4689	Length:	1103	Species:	Homo sapiens

Alignment Length:	969	Identity:	211/969 - (21%)
Similarity:	337/969 - (34%)	Gaps:	328/969 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 PGGSGTSSLASSKEESKHRKFFSRSASLRQAGSGGGGVGVGGVVGGSGSHQASMEL--HVPGQEG 117
            ||....::||:|.:             ||:|                  |.|.:.|  |.| .||
Human   287 PGPEALAALANSSQ-------------LRRA------------------HDAVLTLTRHCP-SEG 319

  Fly   118 RGTSSGAGSPQTQTQPSTPKKSNWEVIEH-FNT----------------SAKGGKAVVSSSLIAA 165
            ....|   ..:.|.:...|...|.:.:.. |.|                :|.||: .||.:.:|.
Human   320 SVLDS---LRRAQERRELPSDLNLQQVSPLFGTIYDAVFLLARGVAEARAAAGGR-WVSGAAVAR 380

  Fly   166 GITRCNI---------DES-----MDSTNSSSTCHSPMIYQRDETQLLQPGDASNLEANNPMSSG 216
            .|....:         ||.     :|:..:.....:        |.:|.|...|.|.|...|..
Human   381 HIRDAQVPGFCGDLGGDEEPPFVLLDTDAAGDRLFA--------TYMLDPARGSFLSAGTRMHF- 436

  Fly   217 GGGGTANGPVSPSISFWFRLNRIILRLCSTHQFKNLQVEMLYQRYFLRMNQSNTTHILA-----L 276
            ..||:|.|| .||.  ||..|.|    |.    ..|:..:::..:.|.:........||     .
Human   437 PRGGSAPGP-DPSC--WFDPNNI----CG----GGLEPGLVFLGFLLVVGMGLAGAFLAHYVRHR 490

  Fly   277 LLALILALSCTLLVFTT-----------------------------LQLRRSTSLLLEISEIGLD 312
            ||.:.:......::.|.                             ..:|...|..|:...||:.
Human   491 LLHMQMVSGPNKIILTVDDITFLHPHGGTSRKVAQGSRSSLGARSMSDIRSGPSQHLDSPNIGVY 555

  Fly   313 ANATV------GNLTTATMKPPTLA--SSDQMTRGSSIPL-----LALASNGS---WAGNGAVGG 361
            ....|      |:...| ::|.|..  |..|..|..::.|     ||..:.|.   |.||.||..
Human   556 EGDRVWLKKFPGDQHIA-IRPATKTAFSKLQELRHENVALYLGLFLARGAEGPAALWEGNLAVVS 619

  Fly   362 ELKSAHNHNIADFEADHNGQLVWRRQKRKHYRRLHKHRYKHKSHQQHRTRYRMREKRSLQDAGLV 426
            |  .....::.|..|....:|.|..:.......:...||.|.....|.   |::.:..:.|...|
Human   620 E--HCTRGSLQDLLAQREIKLDWMFKSSLLLDLIKGIRYLHHRGVAHG---RLKSRNCIVDGRFV 679

  Fly   427 -----KGGG--IQTQLIVD----------TATD---DDA---------DVYTVASDDDDDVDGGR 462
                 .|.|  ::.|.::.          ||.:   |.|         ||:::|....:.|  .|
Human   680 LKITDHGHGRLLEAQKVLPEPPRAEDQLWTAPELLRDPALERRGTLAGDVFSLAIIMQEVV--CR 742

  Fly   463 SAGSKHITYTPRVRDYNQISHAERDEVLNTSSNAGVATDNSDPPLGYGQLIPLILMQVDESVLVF 527
            ||....:..||             :||        |....|.|||    ..||:.|  |::.:..
Human   743 SAPYAMLELTP-------------EEV--------VQRVRSPPPL----CRPLVSM--DQAPVEC 780

  Fly   528 LIVMLICGIVYAFLLCILSKPAMNEIFLVLVSYVILGTFLAIEVAVSYAMQPSKSFNGSACCIVL 592
            :::|..|......|     :|:|:..|.:.                       |:.|
Human   781 ILLMKQCWAEQPEL-----RPSMDHTFDLF-----------------------KNIN-------- 809

  Fly   593 IYMTYTMLPLRLREALIGGILLSVVHLYTCLRLNAMQDEAVEMIHWEELLCTLVALLLANLTGVY 657
                      :.|:..|...:|.::..|:.              :.|:|:
Human   810 ----------KGRKTNIIDSMLRMLEQYSS--------------NLEDLI--------------- 835

  Fly   658 THWPKEKAQRKAFIETRQCIEARLRTQR---ENQQQERLLLSVLPRHVAMEMKDDIAGQPRDTQF 719
                                  |.||:.   |.|:.:|||..:||..||..:|   .|.|.:.::
Human   836 ----------------------RERTEELELEKQKTDRLLTQMLPPSVAEALK---TGTPVEPEY 875

  Fly   720 HKIYIQRHENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYC 784
                   .|.|::.|:||.|||::|......|:|.|||:|:..||.:...|...:::.:||.|..
Human   876 -------FEQVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMV 933

  Fly   785 VSGLPEPRPDHAHCA--VEMGLDMIDAIAL--VREVMAVNVNMRVGIHTGRVHCGVLGLVKWQFD 845
            .||||: |....|.|  ..|.||::.|:..  :|.:..|.|.:|:|:|:|....||:||...::.
Human   934 ASGLPQ-RNGQRHAAEIANMSLDILSAVGTFRMRHMPEVPVRIRIGLHSGPCVAGVVGLTMPRYC 997

  Fly   846 VWSNDVTLANHMESGGIPGRVHITKET---LKCLDGDYEVEV-------GKGNERNSYL 894
            ::.:.|..|:.|||.|:|.|:|:...|   |:.||..|:||:       |||.|...:|
Human   998 LFGDTVNTASRMESTGLPYRIHVNLSTVGILRALDSGYQVELRGRTELKGKGAEDTFWL 1056

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:292831	29/199 (15%)
		CYCc	686..881	CDD:214485	68/201 (34%)
		Guanylate_cyc	722..895	CDD:278633	64/187 (34%)
		DUF1053	<949..1005	CDD:283888
		CYCc	1259..1455	CDD:214485
		Guanylate_cyc	1285..1479	CDD:278633
GUCY2D	NP_000171.1	PBP1_sensory_GC_DEF-like	55..431	CDD:380594	36/187 (19%)
		PK_GC-2D	536..811	CDD:270945	69/355 (19%)
		HNOBA	<820..865	CDD:369471	16/95 (17%)
		CYCc	846..1036	CDD:214485	67/200 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1065..1103
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810