DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43373 and GUCY2C

DIOPT Version :9

Sequence 1:	NP_001097622.2	Gene:	CG43373 / 39835	FlyBaseID:	FBgn0263131	Length:	1854	Species:	Drosophila melanogaster
Sequence 2:	NP_004954.2	Gene:	GUCY2C / 2984	HGNCID:	4688	Length:	1073	Species:	Homo sapiens

Alignment Length:	630	Identity:	141/630 - (22%)
Similarity:	243/630 - (38%)	Gaps:	175/630 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   406 QQHRTRYRMREKRSLQDAGLVKGGGIQTQLIVDTATDDDADVYTVASDDDDDVDGGRSAGSKHIT 470
            :::|..|.:|:|         |...|..:.|....|::...| ::..|||...|
Human   455 RKYRKDYELRQK---------KWSHIPPENIFPLETNETNHV-SLKIDDDKRRD----------- 498

  Fly   471 YTPRVRDYNQISHAERDEVL-NTSSNAGVATDNSDPPLGYGQLIPLILMQVDESVL------VFL 528
               .::...|..:.::..:| :...|.|..|:.....|..       |:|:|...|      |.|
Human   499 ---TIQRLRQCKYDKKRVILKDLKHNDGNFTEKQKIELNK-------LLQIDYYNLTKFYGTVKL 553

  Fly   529 IVMLICGIVYAFLLCILSKPAMNEIFLVLVSYVILGTFLAIEVAVSYAMQPSKSFN--------- 584
            ..|:...|.|.      .:.::.|:....:||.. |||:..|..:|.....:|..:
Human   554 DTMIFGVIEYC------ERGSLREVLNDTISYPD-GTFMDWEFKISVLYDIAKGMSYLHSSKTEV 611

  Fly   585 ----GSACCIVLIYMTYTM-----------------LPLRLREALIG--------GILLSVVHL- 619
                .|..|:|...|...:                 .|..||:|.|.        ||:...:.|
Human   612 HGRLKSTNCVVDSRMVVKITDFGCNSILPPKKDLWTAPEHLRQANISQKGDVYSYGIIAQEIILR 676

  Fly   620 ----YT--C----------------------LRLNAMQDEAVEMI-----HWEE----------L 641
                ||  |                      |.|...:::.:|:.     .|||          :
Human   677 KETFYTLSCRDRNEKIFRVENSNGMKPFRPDLFLETAEEKELEVYLLVKNCWEEDPEKRPDFKKI 741

  Fly   642 LCTLVALLLANLTGVYTHWPKEKAQRKAFIETRQCIEARL------RTQ---RENQQQERLLLSV 697
            ..|     ||.:.|:: |..|.::.....|...|.....|      |||   .|..:.:||...:
Human   742 ETT-----LAKIFGLF-HDQKNESYMDTLIRRLQLYSRNLEHLVEERTQLYKAERDRADRLNFML 800

  Fly   698 LPRHVAMEMKDDIAGQPRDTQFHKIYIQRHENVSILFADICGFTSLSDQCTAEELVRLLNELFAR 762
            |||.|...:|:....:|          :.:|.|:|.|:||.|||::....|..|:|.:||:::..
Human   801 LPRLVVKSLKEKGFVEP----------ELYEEVTIYFSDIVGFTTICKYSTPMEVVDMLNDIYKS 855

  Fly   763 FDRLAAEHHCLRIKLLGDCYYCVSGLPEPRPD-HAHCAVEMGLDMIDAIAL--VREVMAVNVNMR 824
            ||.:...|...:::.:||.|...||||:...: ||....:|.|:::..:..  :..:..:.:.:|
Human   856 FDHIVDHHDVYKVETIGDAYMVASGLPKRNGNRHAIDIAKMALEILSFMGTFELEHLPGLPIWIR 920

  Fly   825 VGIHTGRVHCGVLGLVKWQFDVWSNDVTLANHMESGGIPGRVHITKETLKCLDGD-----YEVE- 883
            :|:|:|....||:|:...::.::.:.|..|:.|||.|:|.|:|::..|:..|...     |||.
Human   921 IGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHVSGSTIAILKRTECQFLYEVRG 985

  Fly   884 ----VGKGNERNSYL---KDHQIETYLIVPGDIYRPHKKSRNRLQ 921
                .|:|||...:|   ||.:..  |..|     |..:::.|||
Human   986 ETYLKGRGNETTYWLTGMKDQKFN--LPTP-----PTVENQQRLQ 1023

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43373	NP_001097622.2	AC_N	<523..720	CDD:292831	57/293 (19%)
		CYCc	686..881	CDD:214485	55/202 (27%)
		Guanylate_cyc	722..895	CDD:278633	54/188 (29%)
		DUF1053	<949..1005	CDD:283888
		CYCc	1259..1455	CDD:214485
		Guanylate_cyc	1285..1479	CDD:278633
GUCY2C	NP_004954.2	PBP1_GC_C_enterotoxin_receptor	35..415	CDD:107364
		PK_GC-C	480..750	CDD:270946	54/303 (18%)
		Pkinase_Tyr	502..745	CDD:285015	46/261 (18%)
		CYCc	788..979	CDD:214485	55/200 (28%)
		Guanylate_cyc	815..1002	CDD:278633	55/196 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810